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PEPDIA-INT-044040

Gold

(KW)4

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

KWKWKWKW

Indexed sequence8 aa

1KWKWKWKW

Length

Molecular weight

1275.57 Da

Formula

C68H90N16O9

Structure type

Linear

Synthesis

Synthetic

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar0

Solubility proxy

Charged4

Net charge proxy +4

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1275.5441 Da

Molecular formula

C68H90N16O9

Theoretical pI

10.4777

Net charge at pH 7

3.7561

GRAVY

-2.4

Instability index

8.75

Aromaticity

0.5

Topological polar surface area

434.26 Å²

cLogP

3.2039

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

KWKWKWKW

HELM 2.0

validated simple linear

PEPTIDE1{K.W.K.W.K.W.K.W}$$$$V2.0

Canonical SMILES

validated

NCCCCC(N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O

Isomeric SMILES

validated

NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-044040,
  title = {(KW)4},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-044040},
  note = {Accessed from local PepDiana development build}
}

APA-style note

(KW)4. (2026). PepDiana record PEPDIA-INT-044040. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-044040

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (36 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P044040_ACT_camp_0000	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ11929camp / linked
CTPDB_P044040_ACT_dbaasp_0001	Antimicrobial	-	6.25 µM	Escherichia coli KCTC 1682	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0002	Antimicrobial	-	12.5 µM	Escherichia coli KCTC 1682	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0003	Antimicrobial	-	1.56 µM	Salmonella typhimurium KCTC 1926	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0004	Antimicrobial	-	3.12 µM	Pseudomonas aeruginosa KCTC 1637	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0005	Antimicrobial	-	6.25 µM	Staphylococcus aureus KCTC 1621	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0006	Antimicrobial	-	12.5 µM	Staphylococcus aureus KCTC 1621	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0007	Antimicrobial	-	6.25 µM	Bacillus subtilis KCTC 1918	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0008	Antimicrobial	-	12.5 µM	Bacillus subtilis KCTC 1918	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0009	Antimicrobial	-	3.12 µM	Listeria monocytogenes KCTC 3710	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0010	Antimicrobial	-	6.25 µM	Escherichia coli CCARM 1229	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0011	Antimicrobial	-	12.5 µM	Escherichia coli CCARM 1229	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0012	Antimicrobial	-	12.5 µM	Escherichia coli CCARM 1238	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0013	Antimicrobial	-	12.5 µM	Salmonella typhimurium CCARM 8007	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0014	Antimicrobial	-	6.25 µM	Salmonella typhimurium CCARM 8009	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0015	Antimicrobial	-	12.5 µM	Salmonella typhimurium CCARM 8009	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0016	Antimicrobial	-	6.25 µM	Salmonella typhimurium CCARM 8013	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0017	Antimicrobial	-	12.5 µM	Salmonella typhimurium CCARM 8013	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0018	Antimicrobial	-	12.5 µM	Staphylococcus aureus CCARM 3089	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0019	Antimicrobial	-	12.5 µM	Staphylococcus aureus CCARM 3090	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0020	Antimicrobial	-	12.5 µM	Staphylococcus aureus CCARM 3108	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0021	Antimicrobial	-	12.5 µM	Staphylococcus aureus CCARM 3114	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0022	Antimicrobial	-	12.5 µM	Staphylococcus aureus CCARM 3126	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0023	Antimicrobial	-	50 µM	Candida albicans ATCC 64550	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0024	Antimicrobial	-	8 µM	Candida albicans KCTC 7270	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0025	Antimicrobial	-	32 µM	Candida albicans KCTC 7270	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0026	Antimicrobial	-	32 µM	Candida albicans CCARM 14001	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dbaasp_0027	Antimicrobial	-	32 µM	Candida albicans CCARM 14007	Not reported by source	DBAASPS_4495_chain0dbaasp / linked
CTPDB_P044040_ACT_dramp_0028	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03914dramp / linked
CTPDB_P044040_ACT_dramp_0029	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP03914dramp / linked
CTPDB_P044040_ACT_dramp_0030	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP27639dramp / linked
CTPDB_P044040_ACT_dramp_0031	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP27639dramp / linked
CTPDB_P044040_ACT_dramp_0032	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP27639dramp / linked
CTPDB_P044040_ACT_hemolytik_0033	Toxicity	Hemolytic	200.0 µM	Erythrocytes	Not reported by source	2605hemolytik / linked
CTPDB_P044040_ACT_satpdb_0034	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb13888satpdb / linked
CTPDB_P044040_ACT_satpdb_0035	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb13888satpdb / linked

Provenance

Source database records (6)

camp

CAMPSQ11929

Raw sequence

KWKWKWKW

dbaasp

DBAASPS_4495_chain0

Raw sequence

KWKWKWKW

dramp

DRAMP03914

Raw sequence

KWKWKWKW

dramp

DRAMP27639

Raw sequence

KWKWKWKW

hemolytik

2605

Raw sequence

KWKWKWKW

satpdb

satpdb13888

Raw sequence

KWKWKWKW

Citation trail

Literature (4 records)

-

--PMID 28105725

Effect of repetitive lysine-tryptophan motifs on the bactericidal activity of antimicrobial peptides.

Gopal R, Seo C, Song P, Park Y

Amino Acids2013PMID 22914980

Effect of repetitive lysine-tryptophan motifs on the bactericidal activity of antimicrobial peptides.

Gopal R, Seo C, Song P, Park Y

Amino Acids2013PMID 32443520

Antifungal Activity of (KW)n or (RW)n Peptide against Fusarium solani and Fusarium oxysporum.

Gopal R, Na H, Seo CH, Park Y.

Int J Mol Sci2012PMID 23203110

IP evidence

Patents (1)

US 10301354

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:15.023171+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "200",
      "source_db": "dbaasp",
      "assay_method": "8% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "210",
      "source_db": "dbaasp",
      "assay_method": "10% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human keratinocytes HaCat"
    }
  ]
}

Source metadata

[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCCCCC"
}