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PEPDIA-INT-043987

Gold

Alyteserin-2a

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

ILGKLLSTAAGLLSNL

Indexed sequence16 aa

1ILGKLLSTAAGLLSNL

Length

Molecular weight

1583.94 Da

Formula

C72H130N18O21

Structure type

Linear

Synthesis

Ribosomal

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic9

Membrane affinity proxy

Polar4

Solubility proxy

Charged1

Net charge proxy +1

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1583.9103 Da

Molecular formula

C72H130N18O21

Theoretical pI

8.7501

Net charge at pH 7

0.7591

GRAVY

1.275

Instability index

10.8

Aromaticity

Topological polar surface area

629.62 Å²

cLogP

-5.3346

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

ILGKLLSTAAGLLSNL

HELM 2.0

validated simple linear

PEPTIDE1{I.L.G.K.L.L.S.T.A.A.G.L.L.S.N.L}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(N)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C(=O)NC(C)C(=O)NC(C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)O)C(C)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-043987,
  title = {Alyteserin-2a},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-043987},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Alyteserin-2a. (2026). PepDiana record PEPDIA-INT-043987. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-043987

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (30 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P043987_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP01461apd / linked
CTPDB_P043987_ACT_apd_0001	Metabolic/Cardiovascular	Antidiabetic	Not available in the current structured import	Unknown	Not reported by source	AP01461apd / linked
CTPDB_P043987_ACT_apd_0002	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	AP01461apd / linked
CTPDB_P043987_ACT_camp_0003	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3253camp / linked
CTPDB_P043987_ACT_camp_0004	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3253camp / linked
CTPDB_P043987_ACT_camp_0005	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9507camp / linked
CTPDB_P043987_ACT_dbaasp_0006	Antimicrobial	-	150 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0007	Antimicrobial	-	50 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0008	Antimicrobial	-	256 µM	Escherichia coli ATCC 25726	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0009	Antimicrobial	-	80 µM	Human lung carcinoma A549	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0010	Antimicrobial	-	65 µM	Human breast adenocarcinoma MDA-MB-231	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0011	Antimicrobial	-	80 µM	Human colon adenocarcinoma HT29	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0012	Antimicrobial	-	85 µM	Human hepatocellular carcinoma HepG2	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0013	Antimicrobial	-	64 µM	Staphylococcus epidermidis RP62A	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0014	Antimicrobial	-	32 µM	Staphylococcus epidermidis RP62A/1	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0015	Antimicrobial	-	256 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0016	Antimicrobial	-	256 µM	Klebsiella pneumoniae ATCC 700603	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0017	Antimicrobial	-	64 µM	Acinetobacter baumannii NM8	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0018	Antimicrobial	-	128 µM	Stenotrophomonas maltophilia B32/4	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dbaasp_0019	Antimicrobial	-	64 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_2407_chain0dbaasp / linked
CTPDB_P043987_ACT_dramp_0020	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP01082dramp / linked
CTPDB_P043987_ACT_dramp_0021	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP01082dramp / linked
CTPDB_P043987_ACT_dramp_0022	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP01082dramp / linked
CTPDB_P043987_ACT_dramp_0023	Anticancer	Cytotoxic	Not available in the current structured import	Unknown	Not reported by source	DRAMP01082dramp / linked
CTPDB_P043987_ACT_hemolytik_0024	Toxicity	Hemolytic	140.0 µM	Erythrocytes	Not reported by source	3168hemolytik / linked
CTPDB_P043987_ACT_satpdb_0025	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb15283satpdb / linked
CTPDB_P043987_ACT_satpdb_0026	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb16412satpdb / linked
CTPDB_P043987_ACT_satpdb_0027	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb16412satpdb / linked
CTPDB_P043987_ACT_satpdb_0028	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb16412satpdb / linked
CTPDB_P043987_ACT_satpdb_0029	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb16412satpdb / linked

Provenance

Source database records (8)

apd

AP01461

Raw sequence

ILGKLLSTAAGLLSNL

camp

CAMPSQ3253

Raw sequence

ILGKLLSTAAGLLSNL

camp

CAMPSQ9507

Raw sequence

ILGKLLSTAAGLLSNL

dbaasp

DBAASPS_2407_chain0

Raw sequence

ILGKLLSTAAGLLSNL

dramp

DRAMP01082

Raw sequence

ILGKLLSTAAGLLSNL

hemolytik

3168

Raw sequence

ILGKLLSTAAGLLSNL

satpdb

satpdb15283

Raw sequence

ILGKLLSTAAGLLSNL

satpdb

satpdb16412

Raw sequence

ILGKLLSTAAGLLSNL

Citation trail

Literature (4 records)

The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae).

Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC.2009

Peptides2009PMID 19463738

-

--PMID 31102497

The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae).

Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC

Peptides2009PMID 22965637

The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae).

Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC

Peptides2009PMID 22392897

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.491115+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "135-140",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref:19463738] LC50 = 135 μM against human erthrocytes.",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCTTHHHHHHHHTC"
}