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PEPDIA-INT-043936

Gold

Gaegurin 5 (1-11)[G3K][A4W][V8W][S10K]

85

Quality

7

Source DBs

90

Activities

38

Source refs

3

Literature

1

Patents

Integrated record

Sequence and molecular profile

FLKWLFKWAKK
Indexed sequence11 aa
1FLKWLFKWAKK

Length

11

Molecular weight

1494.90 Da

Formula

C79H115N17O12

Structure type

Linear

Synthesis

Synthetic

Chirality

L

Family

-

Gene

-

Residue composition

K
4
F
2
L
2
W
2
A
1

Physicochemical profile

Hydrophobic7

Membrane affinity proxy

Polar0

Solubility proxy

Charged4

Net charge proxy +4

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1494.865 Da

Molecular formula

C79H115N17O12

Theoretical pI

10.4777

Net charge at pH 7

3.7561

GRAVY

-0.2182

Instability index

-14.7364

Aromaticity

0.3636

Topological polar surface area

489.98 Ų

cLogP

2.8078

Hydrogen-bond donors

18

Hydrogen-bond acceptors

16

Rotatable bonds

49

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

FLKWLFKWAKK

HELM 2.0

validated simple linear

PEPTIDE1{F.L.K.W.L.F.K.W.A.K.K}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(N)Cc1ccccc1)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-043936,
  title = {Gaegurin 5 (1-11)[G3K][A4W][V8W][S10K]},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-043936},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Gaegurin 5 (1-11)[G3K][A4W][V8W][S10K]. (2026). PepDiana record PEPDIA-INT-043936. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-043936

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (90 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P043936_ACT_apd_0000AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceAP05675apd / linked
CTPDB_P043936_ACT_apd_0001ToxicityHemolyticNot available in the current structured importUnknownNot reported by sourceAP05675apd / linked
CTPDB_P043936_ACT_camp_0002AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ19224camp / linked
CTPDB_P043936_ACT_camp_0003AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ19224camp / linked
CTPDB_P043936_ACT_cancerppd_0034AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1716cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0035Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1716cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0036AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1717cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0037Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1717cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0038AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1718cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0039Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1718cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0040AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1719cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0041Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1719cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0042AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1720cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0043Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1720cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0044AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1721cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0045Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1721cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0046AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1735cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0047Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1735cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0048AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1739cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0049Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1739cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0050AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1749cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0051Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1749cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0052AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1750cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0053Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1750cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0054AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1751cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0055Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1751cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0056AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1752cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0057Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1752cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0058AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1753cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0059Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1753cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0060AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1754cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0061Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1754cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0062AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1755cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0063Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1755cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0064AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1756cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0065Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1756cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0004AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3247cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0005Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3247cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0006AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3248cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0007Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3248cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0008AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3249cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0009Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3249cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0010AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3250cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0011Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3250cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0012AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3251cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0013Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3251cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0014AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3252cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0015Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3252cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0016AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3253cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0017Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3253cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0018AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3747cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0019Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3747cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0020AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3748cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0021Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3748cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0022AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3749cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0023Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3749cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0024AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3750cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0025Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3750cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0026AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3751cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0027Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3751cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0028AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3752cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0029Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3752cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0030AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3753cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0031Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3753cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0032AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3754cancerppd / linked
CTPDB_P043936_ACT_cancerppd_0033Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3754cancerppd / linked
CTPDB_P043936_ACT_dbaasp_0066Antimicrobial-3.1 µg/mlBacillus subtilis ATCC 6633Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0067Antimicrobial-3.1 µg/mlMicrococcus luteus ATCC 10240Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0068Antimicrobial-6.3 µg/mlStaphylococcus aureus ATCC 6538PNot reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0069Antimicrobial-6.3 µg/mlStaphylococcus epidermidis ATCC 12228Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0070Antimicrobial-12.5 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0071Antimicrobial-25 µg/mlShigella dysenteriae ATCC 9752Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0072Antimicrobial-50 µg/mlSalmonella enterica subsp. enterica serovar Typhimurium ATCC 14028Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0073Antimicrobial-12.5 µg/mlKlebsiella pneumoniae ATCC 10031Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0074Antimicrobial-12.5 µg/mlPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0075Antimicrobial-21.48 µMHuman renal carcinoma A498Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0076Antimicrobial-14.53 µMHuman lung carcinoma A549Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0077Antimicrobial-14.80 µMHuman colon adenocarcinoma HCT 116Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0078Antimicrobial-22.51 µMHuman gastric cancer MKN 45Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0079Antimicrobial-29.10 µMHuman prostate adenocarcinoma PC-3Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0080Antimicrobial-22.25 µMHuman skin melanoma SK-MEL-2Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dbaasp_0081Antimicrobial-12.55 µMHuman ovarian adenocarcinoma SK-OV-3Not reported by sourceDBAASPS_943_chain0dbaasp / linked
CTPDB_P043936_ACT_dramp_0082Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP09409dramp / linked
CTPDB_P043936_ACT_dramp_0083Anticancer-Not available in the current structured importUnknownNot reported by sourceDRAMP09409dramp / linked
CTPDB_P043936_ACT_hemolytik_0084ToxicityHemolytic6.3 µg/mlErythrocytesNot reported by source1557hemolytik / linked
CTPDB_P043936_ACT_satpdb_0085Anticancer-Not available in the current structured importUnknownNot reported by sourcesatpdb22780satpdb / linked
CTPDB_P043936_ACT_satpdb_0086ToxicityGeneral ToxicNot available in the current structured importUnknownNot reported by sourcesatpdb22780satpdb / linked
CTPDB_P043936_ACT_satpdb_0087Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb22780satpdb / linked
CTPDB_P043936_ACT_satpdb_0088Anticancer-Not available in the current structured importUnknownNot reported by sourcesatpdb24865satpdb / linked
CTPDB_P043936_ACT_satpdb_0089Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb24865satpdb / linked

Provenance

Source database records (38)

apd

AP05675

Raw sequence

FLKWLFKWAKK

camp

CAMPSQ19224

Raw sequence

FLKWLFKWAKK

cancerppd

3247

Raw sequence

FLKWLFKWAKK

cancerppd

3248

Raw sequence

FLKWLFKWAKK

cancerppd

3249

Raw sequence

FLKWLFKWAKK

cancerppd

3250

Raw sequence

FLKWLFKWAKK

cancerppd

3251

Raw sequence

FLKWLFKWAKK

cancerppd

3252

Raw sequence

FLKWLFKWAKK

cancerppd

3253

Raw sequence

FLKWLFKWAKK

cancerppd

3747

Raw sequence

FLKWLFKWAKK

cancerppd

3748

Raw sequence

FLKWLFKWAKK

cancerppd

3749

Raw sequence

FLKWLFKWAKK

cancerppd

3750

Raw sequence

FLKWLFKWAKK

cancerppd

3751

Raw sequence

FLKWLFKWAKK

cancerppd

3752

Raw sequence

FLKWLFKWAKK

cancerppd

3753

Raw sequence

FLKWLFKWAKK

cancerppd

3754

Raw sequence

FLKWLFKWAKK

cancerppd

1716

Raw sequence

FLKWLFKWAKK

cancerppd

1717

Raw sequence

FLKWLFKWAKK

cancerppd

1718

Raw sequence

FLKWLFKWAKK

cancerppd

1719

Raw sequence

FLKWLFKWAKK

cancerppd

1720

Raw sequence

FLKWLFKWAKK

cancerppd

1721

Raw sequence

FLKWLFKWAKK

cancerppd

1735

Raw sequence

FLKWLFKWAKK

cancerppd

1739

Raw sequence

FLKWLFKWAKK

cancerppd

1749

Raw sequence

FLKWLFKWAKK

cancerppd

1750

Raw sequence

FLKWLFKWAKK

cancerppd

1751

Raw sequence

FLKWLFKWAKK

cancerppd

1752

Raw sequence

FLKWLFKWAKK

cancerppd

1753

Raw sequence

FLKWLFKWAKK

cancerppd

1754

Raw sequence

FLKWLFKWAKK

cancerppd

1755

Raw sequence

FLKWLFKWAKK

cancerppd

1756

Raw sequence

FLKWLFKWAKK

dbaasp

DBAASPS_943_chain0

Raw sequence

FLKWLFKWAKK

dramp

DRAMP09409

Raw sequence

FLKWLFKWAKK

hemolytik

1557

Raw sequence

FLKWLFKWAKK

satpdb

satpdb22780

Raw sequence

FLKWLFKWAKK

satpdb

satpdb24865

Raw sequence

FLKWLFKWAKK

Citation trail

Literature (3 records)

Activity optimization of an undecapeptide analogue derived from a frog-skin antimicrobial peptide.

Won HS, Kang SJ, Choi WS, Lee BJ. 2011

Mol Cells2011PMID 21110126

{"pubmed_id": "[None](http://www.ncbi.nlm.nih.gov/pubmed/None)", "year": "2011"}

-

--

IP evidence

Patents (1)

US 8076284

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.385336+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "6.3",
      "source_db": "dbaasp",
      "assay_method": "5% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}
Source metadata
[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "source_db": "satpdb",
  "dssp_states": "CHHHHTTGGGC"
}