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PEPDIA-INT-043474

Silver

R(R)KW

65

Quality

2

Source DBs

63

Activities

15

Source refs

4

Literature

0

Patents

Integrated record

Sequence and molecular profile

R
Indexed sequence1 aa
1R

Length

1

Molecular weight

174.20 Da

Formula

C6H14N4O2

Structure type

-

Synthesis

Synthetic

Chirality

-

Family

-

Gene

-

Residue composition

R
1

Physicochemical profile

Hydrophobic0

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy +1

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

174.201 Da

Molecular formula

C6H14N4O2

Theoretical pI

9.75

Net charge at pH 7

0.7601

GRAVY

-4.5

Instability index

0

Aromaticity

0

Topological polar surface area

125.22 Ų

cLogP

-1.3384

Hydrogen-bond donors

5

Hydrogen-bond acceptors

3

Rotatable bonds

5

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

R

HELM 2.0

validated simple linear

PEPTIDE1{R}$$$$V2.0

Canonical SMILES

validated

N=C(N)NCCCC(N)C(=O)O

Isomeric SMILES

validated

N=C(N)NCCC[C@H](N)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-043474,
  title = {R(R)KW},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-043474},
  note = {Accessed from local PepDiana development build}
}

APA-style note

R(R)KW. (2026). PepDiana record PEPDIA-INT-043474. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-043474

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (63 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P043474_ACT_camp_0000AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ13013camp / linked
CTPDB_P043474_ACT_camp_0001AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceCAMPSQ13013camp / linked
CTPDB_P043474_ACT_camp_0002AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ13013camp / linked
CTPDB_P043474_ACT_dbaasp_0003Antimicrobial->128 µMStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_22446_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0004Antimicrobial->128 µMBacillus subtilis ATCC 23857Not reported by sourceDBAASPS_22446_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0005Antimicrobial->128 µMAcinetobacter baumannii ATCC 19606Not reported by sourceDBAASPS_22446_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0006Antimicrobial->128 µMKlebsiella pneumoniae ATCC 700603Not reported by sourceDBAASPS_22446_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0007Antimicrobial->128 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_22446_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0008Antimicrobial->128 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_22446_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0009Antimicrobial->128 µMStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_22467_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0010Antimicrobial->128 µMBacillus subtilis ATCC 23857Not reported by sourceDBAASPS_22467_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0011Antimicrobial->128 µMAcinetobacter baumannii ATCC 19606Not reported by sourceDBAASPS_22467_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0012Antimicrobial->128 µMKlebsiella pneumoniae ATCC 700603Not reported by sourceDBAASPS_22467_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0013Antimicrobial->128 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_22467_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0014Antimicrobial->128 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_22467_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0015Antimicrobial-32 µMStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_22469_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0016Antimicrobial-32 µMBacillus subtilis ATCC 23857Not reported by sourceDBAASPS_22469_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0017Antimicrobial->128 µMAcinetobacter baumannii ATCC 19606Not reported by sourceDBAASPS_22469_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0018Antimicrobial->128 µMKlebsiella pneumoniae ATCC 700603Not reported by sourceDBAASPS_22469_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0019Antimicrobial->128 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_22469_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0020Antimicrobial-32 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_22469_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0021Antimicrobial-0.25 µg/mlEscherichia coli NCIB 8879Not reported by sourceDBAASPS_23438_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0022Antimicrobial-<0.12 µg/mlKlebsiella aerogenesNot reported by sourceDBAASPS_23438_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0023Antimicrobial-1 µg/mlEnterobacter sp.Not reported by sourceDBAASPS_23438_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0024Antimicrobial-2 µg/mlSerratia marcescens ATCC 14756Not reported by sourceDBAASPS_23438_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0025Antimicrobial-32 µg/mlSalmonella typhimuriumNot reported by sourceDBAASPS_23438_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0026Antimicrobial-128 µg/mlHaemophilus influenzae NCTC 4560Not reported by sourceDBAASPS_23438_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0027Antimicrobial-16 µg/mlEnterococcus faecalisNot reported by sourceDBAASPS_23438_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0028Antimicrobial-16 µg/mlStaphylococcus aureus NCIB 8625Not reported by sourceDBAASPS_23438_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0029Antimicrobial->128 µg/mlPseudomonas aeruginosa PAO1Not reported by sourceDBAASPS_23927_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0030Antimicrobial->128 µg/mlAcinetobacter baumannii ATCC 17978Not reported by sourceDBAASPS_23927_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0031Antimicrobial->128 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_23927_chain0dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0032Antimicrobial->128 µg/mlPseudomonas aeruginosa PAO1Not reported by sourceDBAASPS_23927_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0033Antimicrobial->128 µg/mlAcinetobacter baumannii ATCC 17978Not reported by sourceDBAASPS_23927_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0034Antimicrobial->128 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_23927_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0035Antimicrobial-32 µg/mlPseudomonas aeruginosa PAO1Not reported by sourceDBAASPS_23929_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0036Antimicrobial-64 µg/mlAcinetobacter baumannii ATCC 17978Not reported by sourceDBAASPS_23929_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0037Antimicrobial-4 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_23929_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0038Antimicrobial-32 µg/mlPseudomonas aeruginosa PAO1Not reported by sourceDBAASPS_23929_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0039Antimicrobial-64 µg/mlAcinetobacter baumannii ATCC 17978Not reported by sourceDBAASPS_23929_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0040Antimicrobial-4 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_23929_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0041Antimicrobial->128 µg/mlPseudomonas aeruginosa PAO1Not reported by sourceDBAASPS_23931_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0042Antimicrobial->128 µg/mlAcinetobacter baumannii ATCC 17978Not reported by sourceDBAASPS_23931_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0043Antimicrobial->128 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_23931_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0044Antimicrobial-32 µg/mlStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_23931_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0045Antimicrobial-32 µg/mlStaphylococcus aureus ATCC 33592Not reported by sourceDBAASPS_23931_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0046Antimicrobial-8 µg/mlStaphylococcus epidermidis 81388Not reported by sourceDBAASPS_23931_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0047Antimicrobial-32 µg/mlStaphylococcus epidermidis 61589Not reported by sourceDBAASPS_23931_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0048Antimicrobial->128 µg/mlEnterococcus faecalis ATCC 29212Not reported by sourceDBAASPS_23931_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0049Antimicrobial-32 µg/mlEnterococcus faecium ATCC 27270Not reported by sourceDBAASPS_23931_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0050Antimicrobial->128 µg/mlKlebsiella pneumoniaeNot reported by sourceDBAASPS_23931_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0051Antimicrobial->128 µg/mlEnterobacter cloacaeNot reported by sourceDBAASPS_23931_chain1dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0052Antimicrobial->128 µg/mlPseudomonas aeruginosa PAO1Not reported by sourceDBAASPS_23931_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0053Antimicrobial->128 µg/mlAcinetobacter baumannii ATCC 17978Not reported by sourceDBAASPS_23931_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0054Antimicrobial->128 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_23931_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0055Antimicrobial-32 µg/mlStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_23931_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0056Antimicrobial-32 µg/mlStaphylococcus aureus ATCC 33592Not reported by sourceDBAASPS_23931_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0057Antimicrobial-8 µg/mlStaphylococcus epidermidis 81388Not reported by sourceDBAASPS_23931_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0058Antimicrobial-32 µg/mlStaphylococcus epidermidis 61589Not reported by sourceDBAASPS_23931_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0059Antimicrobial->128 µg/mlEnterococcus faecalis ATCC 29212Not reported by sourceDBAASPS_23931_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0060Antimicrobial-32 µg/mlEnterococcus faecium ATCC 27270Not reported by sourceDBAASPS_23931_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0061Antimicrobial->128 µg/mlKlebsiella pneumoniaeNot reported by sourceDBAASPS_23931_chain2dbaasp / linked
CTPDB_P043474_ACT_dbaasp_0062Antimicrobial->128 µg/mlEnterobacter cloacaeNot reported by sourceDBAASPS_23931_chain2dbaasp / linked

Provenance

Source database records (15)

camp

CAMPSQ13013

Raw sequence

R

dbaasp

DBAASPS_22444_chain0

Raw sequence

R

dbaasp

DBAASPS_22446_chain0

Raw sequence

R

dbaasp

DBAASPS_22467_chain0

Raw sequence

R

dbaasp

DBAASPS_22469_chain0

Raw sequence

R

dbaasp

DBAASPS_23438_chain0

Raw sequence

R

dbaasp

DBAASPS_23925_chain0

Raw sequence

R

dbaasp

DBAASPS_23927_chain0

Raw sequence

R

dbaasp

DBAASPS_23927_chain1

Raw sequence

R

dbaasp

DBAASPS_23928_chain0

Raw sequence

R

dbaasp

DBAASPS_23929_chain1

Raw sequence

R

dbaasp

DBAASPS_23929_chain2

Raw sequence

R

dbaasp

DBAASPS_23930_chain0

Raw sequence

R

dbaasp

DBAASPS_23931_chain1

Raw sequence

R

dbaasp

DBAASPS_23931_chain2

Raw sequence

R

Citation trail

Literature (4 records)

Arginine and tryptophan-rich dendritic antimicrobial peptides that disrupt membranes for bacterial infection in vivo

Yang Y, Yu Z, Ba Z, Ouyang X, Li B, Yang P, Zhang J, Wang Y, Liu Y, Yang T, Zhao Y, Wu X, Zhong C, Liu H, Zhang Y, Gou S, Ni J

Eur J Med Chem2024PMID 38691892

Synthesis and structure-activity relationships of antibacterial phosphonopeptides incorporating (1-aminoethyl)phosphonic acid and (aminomethyl)phosphonic acid

Atherton FR, Hassall CH, Lambert RW

J Med Chem1986PMID 3510298

Dilipid Ultrashort Tetrabasic Peptidomimetics Potentiate Novobiocin and Rifampicin Against Multidrug-Resistant Gram-Negative Bacteria.

Ramirez D, Berry L, Domalaon R, Brizuela M, Schweizer F

ACS Infect Dis2020PMID 32357292

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:15.023171+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µM",
      "value": ">256",
      "source_db": "dbaasp",
      "assay_method": "10% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    },
    {
      "unit": "µM",
      "value": ">128",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human embryonic kidney HEK293T cells"
    },
    {
      "unit": "µM",
      "value": ">256",
      "source_db": "dbaasp",
      "assay_method": "10% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    },
    {
      "value": ">128",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human embryonic kidney HEK293T cells"
    },
    {
      "unit": "µM",
      "value": ">256",
      "source_db": "dbaasp",
      "assay_method": "10% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    },
    {
      "unit": "µM",
      "value": ">128",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human embryonic kidney HEK293T cells"
    },
    {
      "unit": "µg/ml",
      "value": "128",
      "source_db": "dbaasp",
      "assay_method": "16.7±2.1% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "512",
      "source_db": "dbaasp",
      "assay_method": "28.6±8.5% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "128",
      "source_db": "dbaasp",
      "assay_method": "16.7±2.1% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "512",
      "source_db": "dbaasp",
      "assay_method": "28.6±8.5% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "16",
      "source_db": "dbaasp",
      "assay_method": "7.7±11.0% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "32",
      "source_db": "dbaasp",
      "assay_method": "69.4±5.4% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "64",
      "source_db": "dbaasp",
      "assay_method": "100% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "16",
      "source_db": "dbaasp",
      "assay_method": "7.7±11.0% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "32",
      "source_db": "dbaasp",
      "assay_method": "69.4±5.4% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "64",
      "source_db": "dbaasp",
      "assay_method": "100% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "128",
      "source_db": "dbaasp",
      "assay_method": "9.6±2.7% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "512",
      "source_db": "dbaasp",
      "assay_method": "16.8±7.3% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "128",
      "source_db": "dbaasp",
      "assay_method": "9.6±2.7% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "512",
      "source_db": "dbaasp",
      "assay_method": "16.8±7.3% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Pig erythrocytes"
    }
  ]
}
Source metadata
[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  }
]