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PEPDIA-INT-043025

Gold

Defensin-derived L-Peptide A

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

RLYLRIGRR

Indexed sequence9 aa

1RLYLRIGRR

Length

Molecular weight

1202.48 Da

Formula

C53H95N21O11

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar0

Solubility proxy

Charged4

Net charge proxy +4

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1202.4554 Da

Molecular formula

C53H95N21O11

Theoretical pI

Net charge at pH 7

3.7591

GRAVY

-0.8444

Instability index

93.9333

Aromaticity

0.1111

Topological polar surface area

563.95 Å²

cLogP

-3.9522

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

RLYLRIGRR

HELM 2.0

validated simple linear

PEPTIDE1{R.L.Y.L.R.I.G.R.R}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(C)C)NC(=O)C(N)CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-043025,
  title = {Defensin-derived L-Peptide A},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-043025},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Defensin-derived L-Peptide A. (2026). PepDiana record PEPDIA-INT-043025. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-043025

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (31 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P043025_ACT_camp_0000	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ20220camp / linked
CTPDB_P043025_ACT_camp_0001	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ20220camp / linked
CTPDB_P043025_ACT_camp_0002	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ20220camp / linked
CTPDB_P043025_ACT_dbaasp_0003	Antimicrobial	-	600 µg/ml	Staphylococcus aureus KO-4	Not reported by source	DBAASPS_2584_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0004	Antimicrobial	-	400 µg/ml	Pseudomonas aeruginosa	Not reported by source	DBAASPS_2584_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0005	Antimicrobial	-	205±22 µM	Trypanosoma brucei brucei GUT Tat3.1	Not reported by source	DBAASPS_2584_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0006	Antimicrobial	-	2 µg/ml	Staphylococcus aureus ATCC 6538P	Not reported by source	DBAASPS_2584_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0007	Antimicrobial	-	8 µg/ml	Staphylococcus aureus ATCC 6538P	Not reported by source	DBAASPS_2584_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0008	Antimicrobial	-	5 µg/ml	Escherichia coli JM109	Not reported by source	DBAASPS_2584_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0009	Antimicrobial	-	50 µg/ml	Escherichia coli JM109	Not reported by source	DBAASPS_2584_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0010	Antimicrobial	-	25 µg/ml	Trichophyton mentagrophytes IFO 5466	Not reported by source	DBAASPS_2584_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0011	Antimicrobial	-	30 µg/ml	Staphylococcus aureus KO-4	Not reported by source	DBAASPS_2585_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0012	Antimicrobial	-	30 µg/ml	Pseudomonas aeruginosa	Not reported by source	DBAASPS_2585_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0013	Antimicrobial	-	116±16 µM	Trypanosoma brucei brucei GUT Tat3.1	Not reported by source	DBAASPS_2585_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0014	Antimicrobial	-	96±12 µM	Mouse myeloma P3-X63-Ag8.653	Not reported by source	DBAASPS_2585_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0015	Antimicrobial	-	167±18 µM	Human cervical carcinoma HeLa	Not reported by source	DBAASPS_2585_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0016	Antimicrobial	-	330±4 µM	African green monkey kidney cancer Cos-1	Not reported by source	DBAASPS_2585_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0017	Antimicrobial	-	605±67 µM	Human squamous lung carcinoma RERF-LC-AI	Not reported by source	DBAASPS_2585_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0018	Antimicrobial	-	589±11 µM	Human glioblastoma U251-MG	Not reported by source	DBAASPS_2585_chain0dbaasp / linked
CTPDB_P043025_ACT_dbaasp_0019	Antimicrobial	-	>640 µM	Human lung cancer VA-13	Not reported by source	DBAASPS_2585_chain0dbaasp / linked
CTPDB_P043025_ACT_dramp_0020	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP34308dramp / linked
CTPDB_P043025_ACT_dramp_0021	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP34308dramp / linked
CTPDB_P043025_ACT_parapep_0022	Antiparasitic	Antiparasitic	116.0 µM	Unknown	Cell numbers counted by Z1 Coulter Counter	1312parapep / linked
CTPDB_P043025_ACT_parapep_0023	Antiparasitic	Antiparasitic	205.0 µM	Unknown	Cell numbers counted by Z1 Coulter Counter	1317parapep / linked
CTPDB_P043025_ACT_parapep_0024	Antiparasitic	Antiparasitic	Not available in the current structured import	Unknown	Microscopy (Neubauer hemocytometer)	1414parapep / linked
CTPDB_P043025_ACT_parapep_0025	Antiparasitic	Antiparasitic	Not available in the current structured import	Unknown	Microscopy (Neubauer hemocytometer)	1415parapep / linked
CTPDB_P043025_ACT_parapep_0026	Antiparasitic	Antiparasitic	Not available in the current structured import	Unknown	Microscopy (Neubauer hemocytometer)	1418parapep / linked
CTPDB_P043025_ACT_satpdb_0027	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb10435satpdb / linked
CTPDB_P043025_ACT_satpdb_0028	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb10435satpdb / linked
CTPDB_P043025_ACT_satpdb_0029	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb27085satpdb / linked
CTPDB_P043025_ACT_satpdb_0030	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb27085satpdb / linked

Provenance

Source database records (11)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

camp

CAMPSQ20220

Raw sequence

RLYLRIGRR

dbaasp

DBAASPS_2584_chain0

Raw sequence

RLYLRIGRR

dbaasp

DBAASPS_2585_chain0

Raw sequence

rlylriGrr

dramp

DRAMP34308

Raw sequence

rlylriGrr

parapep

1312

Raw sequence

rlylrigrr

parapep

1317

Raw sequence

RLYLRIGRR

parapep

1414

Raw sequence

RLYLRIGRR

parapep

1415

Raw sequence

RLYLRIGRR

parapep

1418

Raw sequence

rlylrigrr

satpdb

satpdb10435

Raw sequence

rlylrigrr

satpdb

satpdb27085

Raw sequence

RLYLRIGRR

Citation trail

Literature (4 records)

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:15.687061+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human brain microvascular endothelial cells HBMEC"
    },
    {
      "unit": "µM",
      "value": "640",
      "source_db": "dbaasp",
      "assay_method": "4% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CTTTCCSCC"
}