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PEPDIA-INT-042391

Gold

Unnamed peptide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

HCKFWW

Indexed sequence6 aa

1HCKFWW

Length

Molecular weight

906.08 Da

Formula

C46H55N11O7S

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic3

Membrane affinity proxy

Polar1

Solubility proxy

Charged2

Net charge proxy +2

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

906.0634 Da

Molecular formula

C46H55N11O7S

Theoretical pI

8.2311

Net charge at pH 7

0.8364

GRAVY

-0.6

Instability index

8.3333

Aromaticity

0.5

Topological polar surface area

295.1 Å²

cLogP

1.5376

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HCKFWW

HELM 2.0

validated simple linear

PEPTIDE1{H.C.K.F.W.W}$$$$V2.0

Canonical SMILES

validated

NCCCCC(NC(=O)C(CS)NC(=O)C(N)Cc1c[nH]cn1)C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O

Isomeric SMILES

validated

NCCCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-042391,
  title = {Unnamed peptide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-042391},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Unnamed peptide. (2026). PepDiana record PEPDIA-INT-042391. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-042391

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (8 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P042391_ACT_dbaasp_0003	Antimicrobial	-	2 µM	HIV-1	Not reported by source	DBAASPS_6674_chain0dbaasp / linked
CTPDB_P042391_ACT_dramp_0004	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP31405dramp / linked
CTPDB_P042391_ACT_dramp_0005	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP31405dramp / linked
CTPDB_P042391_ACT_hipdb_0002	Antiviral	Anti-HIV	90.0 μM	HIV	Not reported by source	HIPdb_HIP1145hipdb / unavailable
CTPDB_P042391_ACT_hipdb_0000	Antiviral	Anti-HIV	2.0 μM	HIV	Not reported by source	HIPdb_HIP75hipdb / unavailable
CTPDB_P042391_ACT_hipdb_0001	Antiviral	Anti-HIV	100.0%	HIV	Not reported by source	HIPdb_HIP77hipdb / unavailable
CTPDB_P042391_ACT_satpdb_0006	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb26234satpdb / linked
CTPDB_P042391_ACT_satpdb_0007	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb26234satpdb / linked

Provenance

Source database records (6)

hipdb

HIPdb_HIP75

Raw sequence

HCKFWW

hipdb

HIPdb_HIP77

Raw sequence

HCKFWW

hipdb

HIPdb_HIP1145

Raw sequence

HCKFWW

dbaasp

DBAASPS_6674_chain0

Raw sequence

HCKFWW

dramp

DRAMP31405

Raw sequence

HCKFWW

satpdb

satpdb26234

Raw sequence

HCKFWW

Citation trail

Literature (4 records)

{"pubmed_id": "US5578573", "paper": "Viral integrase inhibiting peptides", "authors": "Richard A. Houghten, Patricia A. Weber, Ronald H. A. Plasterk, Ramon A. Puras Lutzke", "reference": "Houghten Pharmaceuticals, Inc."}

{"pubmed_id": "US5578573", "paper": "Viral integrase inhibiting peptides", "authors": "Richard A. Houghten, Patricia A. Weber, Ronald H. A. Plasterk, Ramon A. Puras Lutzke", "reference": "Houghten Pharmaceuticals, Inc."}

{"pubmed_id": "8524782.0", "paper": "Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library.", "authors": "Puras Lutzke RA, Eppens NA, Weber PA, Houghten RA, Plasterk RH.", "reference": "Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11456-60."}

{"pubmed_id": "8524782.0", "paper": "Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library.", "authors": "Puras Lutzke RA, Eppens NA, Weber PA, Houghten RA, Plasterk RH.", "reference": "Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11456-60."}

{"pubmed_id": "12951093.0", "paper": "Design and synthesis of dimeric HIV-1 integrase inhibitory peptides.", "authors": "Krajewski K, Long YQ, Marchand C, Pommier Y, Roller PP.", "reference": "Bioorg Med Chem Lett. 2003 Oct 6;13(19):3203-5."}

{"pubmed_id": "12951093.0", "paper": "Design and synthesis of dimeric HIV-1 integrase inhibitory peptides.", "authors": "Krajewski K, Long YQ, Marchand C, Pommier Y, Roller PP.", "reference": "Bioorg Med Chem Lett. 2003 Oct 6;13(19):3203-5."}

Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library.

Puras Lutzke RA, Eppens NA, Weber PA, Houghten RA, Plasterk RH

Proc Natl Acad Sci U S A1995PMID 8524782

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:13.525035+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "hipdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSCCC"
}