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PEPDIA-INT-041981

Gold

Hymenochirin-1B

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

IKLSPETKDNLKKVLKGAIKGAIAVAKMV

Indexed sequence29 aa

1IKLSPETKDNLKKVLKGAIKGAIAVAKMV

Length

Molecular weight

3064.83 Da

Formula

C139H251N37O37S

Structure type

Linear

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic14

Membrane affinity proxy

Polar3

Solubility proxy

Charged9

Net charge proxy +5

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

3064.7706 Da

Molecular formula

C139H251N37O37S

Theoretical pI

10.1256

Net charge at pH 7

4.757

GRAVY

0.169

Instability index

12.7655

Aromaticity

Topological polar surface area

1209.62 Å²

cLogP

-8.69

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

111

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

IKLSPETKDNLKKVLKGAIKGAIAVAKMV

HELM 2.0

validated simple linear

PEPTIDE1{I.K.L.S.P.E.T.K.D.N.L.K.K.V.L.K.G.A.I.K.G.A.I.A.V.A.K.M.V}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(C)C(=O)NC(C(=O)NC(CCCCN)C(=O)NCC(=O)NC(C)C(=O)NC(C(=O)NC(C)C(=O)NC(C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CCSC)C(=O)NC(C(=O)O)C(C)C)C(C)C)C(C)CC)C(C)CC)C(C)C)C(C)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(C)C)[C@@H](C)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-041981,
  title = {Hymenochirin-1B},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-041981},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Hymenochirin-1B. (2026). PepDiana record PEPDIA-INT-041981. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-041981

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (34 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P041981_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP01964apd / linked
CTPDB_P041981_ACT_apd_0001	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP01964apd / linked
CTPDB_P041981_ACT_apd_0002	Metabolic/Cardiovascular	Antidiabetic	Not available in the current structured import	Unknown	Not reported by source	AP01964apd / linked
CTPDB_P041981_ACT_apd_0003	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	AP01964apd / linked
CTPDB_P041981_ACT_camp_0004	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3664camp / linked
CTPDB_P041981_ACT_camp_0005	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3664camp / linked
CTPDB_P041981_ACT_camp_0006	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3664camp / linked
CTPDB_P041981_ACT_camp_0007	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9506camp / linked
CTPDB_P041981_ACT_dbaasp_0008	Antimicrobial	-	20 µM	Escherichia coli ATCC 25726	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0009	Antimicrobial	-	40 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0010	Antimicrobial	-	20 µM	Klebsiella pneumoniae ATCC 700603	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0011	Antimicrobial	-	10 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0012	Antimicrobial	-	80 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0013	Antimicrobial	-	2.5±0.2 µM	Human lung carcinoma A549	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0014	Antimicrobial	-	9.0±0.3 µM	Human breast adenocarcinoma MDA-MB-231	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0015	Antimicrobial	-	9.7±0.2 µM	Human colon adenocarcinoma HT29	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0016	Antimicrobial	-	22.5±1.4 µM	Human hepatocellular carcinoma HepG2	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0017	Antimicrobial	-	6.25 µM	Acinetobacter baumannii	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0018	Antimicrobial	-	6.25 µM	Stenotrophomonas maltophilia	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0019	Antimicrobial	-	25 µM	Klebsiella pneumoniae	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0020	Antimicrobial	-	>100 µM	Proteus mirabilis ATCC 25933	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0021	Antimicrobial	-	12.5 µM	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0022	Antimicrobial	-	3.1 µM	Staphylococcus epidermidis RP62A	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dbaasp_0023	Antimicrobial	-	1.6 µM	Staphylococcus epidermidis RP62A/1	Not reported by source	DBAASPS_3785_chain0dbaasp / linked
CTPDB_P041981_ACT_dramp_0024	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP04654dramp / linked
CTPDB_P041981_ACT_dramp_0025	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP04654dramp / linked
CTPDB_P041981_ACT_hemolytik_0026	Toxicity	Hemolytic	225.0 µM	Erythrocytes	Not reported by source	2090hemolytik / linked
CTPDB_P041981_ACT_satpdb_0027	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb12617satpdb / linked
CTPDB_P041981_ACT_satpdb_0028	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb12617satpdb / linked
CTPDB_P041981_ACT_satpdb_0029	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb12617satpdb / linked
CTPDB_P041981_ACT_satpdb_0030	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb12617satpdb / linked
CTPDB_P041981_ACT_satpdb_0031	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb28108satpdb / linked
CTPDB_P041981_ACT_satpdb_0032	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb28108satpdb / linked
CTPDB_P041981_ACT_satpdb_0033	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb28108satpdb / linked

Provenance

Source database records (8)

apd

AP01964

Raw sequence

IKLSPETKDNLKKVLKGAIKGAIAVAKMV

camp

CAMPSQ3664

Raw sequence

IKLSPETKDNLKKVLKGAIKGAIAVAKMV

camp

CAMPSQ9506

Raw sequence

IKLSPETKDNLKKVLKGAIKGAIAVAKMV

dbaasp

DBAASPS_3785_chain0

Raw sequence

IKLSPETKDNLKKVLKGAIKGAIAVAKMV

dramp

DRAMP04654

Raw sequence

IKLSPETKDNLKKVLKGAIKGAIAVAKMV

hemolytik

2090

Raw sequence

IKLSPETKDNLKKVLKGAIKGAIAVAKMV

satpdb

satpdb12617

Raw sequence

IKLSPETKDNLKKVLKGAIKGAIAVAKMV

satpdb

satpdb28108

Raw sequence

IKLSPETKDNLKKVLKGAIKGAIAVAKMV

Citation trail

Literature (5 records)

The hymenochirins: A family of host-defense peptides from the Congo dwarf clawed frog Hymenochirus boettgeri (Pipidae).

Mechkarska M, Prajeep M, Coquet L, Leprince J, Jouenne T, Vaudry H, King JD, Conlon JM.2012

Peptides2012PMID 22497805

-

--PMID 31102497

The hymenochirins: a family of host-defense peptides from the Congo dwarf clawed frog Hymenochirus boettgeri (Pipidae).

Mechkarska M, Prajeep M, Coquet L, Leprince J, Jouenne T, Vaudry H, King JD, Conlon JM

Peptides2012PMID 24185042

The hymenochirins: a family of host-defense peptides from the Congo dwarf clawed frog Hymenochirus boettgeri (Pipidae).

Mechkarska M, Prajeep M, Coquet L, Leprince J, Jouenne T, Vaudry H, King JD, Conlon JM

Peptides2012PMID 24172540

Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy

Yulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Honggang Hu, Xia Zhao

ACS Chem Biol2019PMID 30789695

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.604459+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "225",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.30789695] It has 5%, 6.3%, 7.7%, 10%, 10.7%, 15.3%, 9%, 15% and 9.7% hemolysis against fresh rabbit blood cells at 0.010, 0.25, 0.5, 1.0, 2.0, 5.0, 10.0, 20.0, 25.0μM",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "No cytotoxicity information found in the reference",
      "toxicity_type": "Cytotoxic"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSSCCCTTHHHHHHHHHHHHHTTTCCCC"
}