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PEPDIA-INT-041482

Gold

Defensin-derived L-Peptide D

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

RLLLRIGRR

Indexed sequence9 aa

1RLLLRIGRR

Length

Molecular weight

1152.46 Da

Formula

C50H97N21O10

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar0

Solubility proxy

Charged4

Net charge proxy +4

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1152.4398 Da

Molecular formula

C50H97N21O10

Theoretical pI

Net charge at pH 7

3.7601

GRAVY

-0.2778

Instability index

93.9333

Aromaticity

Topological polar surface area

543.72 Å²

cLogP

-3.8544

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

RLLLRIGRR

HELM 2.0

validated simple linear

PEPTIDE1{R.L.L.L.R.I.G.R.R}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(N)CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-041482,
  title = {Defensin-derived L-Peptide D},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-041482},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Defensin-derived L-Peptide D. (2026). PepDiana record PEPDIA-INT-041482. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-041482

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (28 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P041482_ACT_camp_0000	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ20222camp / linked
CTPDB_P041482_ACT_camp_0001	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ20222camp / linked
CTPDB_P041482_ACT_camp_0002	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ20222camp / linked
CTPDB_P041482_ACT_dbaasp_0003	Antimicrobial	-	600 µg/ml	Staphylococcus aureus KO-4	Not reported by source	DBAASPS_2590_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0004	Antimicrobial	-	400 µg/ml	Pseudomonas aeruginosa	Not reported by source	DBAASPS_2590_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0005	Antimicrobial	-	325±75 µM	Trypanosoma brucei brucei GUT Tat3.1	Not reported by source	DBAASPS_2590_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0006	Antimicrobial	-	1 µg/ml	Staphylococcus aureus ATCC 6538P	Not reported by source	DBAASPS_2590_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0007	Antimicrobial	-	4 µg/ml	Staphylococcus aureus ATCC 6538P	Not reported by source	DBAASPS_2590_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0008	Antimicrobial	-	2 µg/ml	Escherichia coli JM109	Not reported by source	DBAASPS_2590_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0009	Antimicrobial	-	30 µg/ml	Escherichia coli JM109	Not reported by source	DBAASPS_2590_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0010	Antimicrobial	-	15 µg/ml	Trichophyton mentagrophytes IFO 5466	Not reported by source	DBAASPS_2590_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0011	Antimicrobial	-	20 µg/ml	Staphylococcus aureus KO-4	Not reported by source	DBAASPS_2591_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0012	Antimicrobial	-	60 µg/ml	Pseudomonas aeruginosa	Not reported by source	DBAASPS_2591_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0013	Antimicrobial	-	80±17 µM	Trypanosoma brucei brucei GUT Tat3.1	Not reported by source	DBAASPS_2591_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0014	Antimicrobial	-	52±10 µM	Mouse myeloma P3-X63-Ag8.653	Not reported by source	DBAASPS_2591_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0015	Antimicrobial	-	150±13 µM	Human cervical carcinoma HeLa	Not reported by source	DBAASPS_2591_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0016	Antimicrobial	-	426±12 µM	African green monkey kidney cancer Cos-1	Not reported by source	DBAASPS_2591_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0017	Antimicrobial	-	457±9 µM	Human squamous lung carcinoma RERF-LC-AI	Not reported by source	DBAASPS_2591_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0018	Antimicrobial	-	478±20 µM	Human glioblastoma U251-MG	Not reported by source	DBAASPS_2591_chain0dbaasp / linked
CTPDB_P041482_ACT_dbaasp_0019	Antimicrobial	-	>640 µM	Human lung cancer VA-13	Not reported by source	DBAASPS_2591_chain0dbaasp / linked
CTPDB_P041482_ACT_dramp_0020	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP34311dramp / linked
CTPDB_P041482_ACT_dramp_0021	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP34311dramp / linked
CTPDB_P041482_ACT_parapep_0022	Antiparasitic	Antiparasitic	80.0 µM	Unknown	Cell numbers counted by Z1 Coulter Counter	1315parapep / linked
CTPDB_P041482_ACT_parapep_0023	Antiparasitic	Antiparasitic	325.0 µM	Unknown	Cell numbers counted by Z1 Coulter Counter	1320parapep / linked
CTPDB_P041482_ACT_satpdb_0024	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb18149satpdb / linked
CTPDB_P041482_ACT_satpdb_0025	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb18149satpdb / linked
CTPDB_P041482_ACT_satpdb_0026	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb24888satpdb / linked
CTPDB_P041482_ACT_satpdb_0027	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb24888satpdb / linked

Provenance

Source database records (8)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

camp

CAMPSQ20222

Raw sequence

RLLLRIGRR

dbaasp

DBAASPS_2590_chain0

Raw sequence

RLLLRIGRR

dbaasp

DBAASPS_2591_chain0

Raw sequence

rlllriGrr

dramp

DRAMP34311

Raw sequence

rlllriGrr

parapep

1315

Raw sequence

rlllrigrr

parapep

1320

Raw sequence

RLLLRIGRR

satpdb

satpdb18149

Raw sequence

RLLLRIGRR

satpdb

satpdb24888

Raw sequence

rlllrigrr

Citation trail

Literature (3 records)

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:15.687061+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "640",
      "source_db": "dbaasp",
      "assay_method": "3% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSSCSSCC"
}