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PEPDIA-INT-040838

Gold

Casecidin 15, Beta-casein

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

YQEPVLGPVRGPFPI

Indexed sequence15 aa

1YQEPVLGPVRGPFPI

Length

Molecular weight

1668.96 Da

Formula

C80H121N19O20

Structure type

Linear

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic6

Membrane affinity proxy

Polar1

Solubility proxy

Charged2

Net charge proxy +0

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1668.9318 Da

Molecular formula

C80H121N19O20

Theoretical pI

6.0014

Net charge at pH 7

-0.2381

GRAVY

-0.0333

Instability index

80.7133

Aromaticity

0.1333

Topological polar surface area

598.08 Å²

cLogP

-2.5381

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

YQEPVLGPVRGPFPI

HELM 2.0

validated simple linear

PEPTIDE1{Y.Q.E.P.V.L.G.P.V.R.G.P.F.P.I}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C1CCCN1C(=O)C(Cc1ccccc1)NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)C1CCCN1C(=O)CNC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1CCCN1C(=O)C(CCC(=O)O)NC(=O)C(CCC(N)=O)NC(=O)C(N)Cc1ccc(O)cc1)C(C)C)C(C)C)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(C)C)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-040838,
  title = {Casecidin 15, Beta-casein},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-040838},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Casecidin 15, Beta-casein. (2026). PepDiana record PEPDIA-INT-040838. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-040838

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (12 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P040838_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3636ahtpdb / linked
CTPDB_P040838_ACT_apd_0001	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	AP01399apd / linked
CTPDB_P040838_ACT_camp_0002	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3214camp / linked
CTPDB_P040838_ACT_dbaasp_0003	Antimicrobial	-	0.5 µg/ml	Escherichia coli DH5alpha	Not reported by source	DBAASPS_2308_chain0dbaasp / linked
CTPDB_P040838_ACT_dbaasp_0004	Antimicrobial	-	0.4 µg/ml	Escherichia coli DPC 6053	Not reported by source	DBAASPS_2308_chain0dbaasp / linked
CTPDB_P040838_ACT_dbaasp_0005	Antimicrobial	-	>1.0 µg/ml	Cronobacter sakazakii DPC 5120	Not reported by source	DBAASPS_2308_chain0dbaasp / linked
CTPDB_P040838_ACT_fermfoodb_0006	Antimicrobial	-	Not available in the current structured import	Unknown	LC-MS with Q Exactive Plus hybridquadrupole-Orbitrap mass spectrometer	FermFooDB_Casein_FMDB1755fermfoodb / linked
CTPDB_P040838_ACT_fermfoodb_0007	Antimicrobial	-	Not available in the current structured import	Unknown	nano-ESI tandem mass spectrometry (MS/MS)	FermFooDB_Cheese_FMDB1578fermfoodb / linked
CTPDB_P040838_ACT_fermfoodb_0008	Metabolic/Cardiovascular	ACE Inhibitor	5.3 µM	Unknown	LC-ESI-MS	FermFooDB_Cheese_FMDB338fermfoodb / linked
CTPDB_P040838_ACT_satpdb_0009	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb14571satpdb / linked
CTPDB_P040838_ACT_satpdb_0010	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb14571satpdb / linked
CTPDB_P040838_ACT_satpdb_0011	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb14571satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-004211 View all experimental records

Provenance

Source database records (8)

ahtpdb

3636

Raw sequence

YQEPVLGPVRGPFPI

apd

AP01399

Raw sequence

YQEPVLGPVRGPFPI

camp

CAMPSQ3214

Raw sequence

YQEPVLGPVRGPFPI

dbaasp

DBAASPS_2308_chain0

Raw sequence

YQEPVLGPVRGPFPI

fermfoodb

FermFooDB_Casein_FMDB1755

Raw sequence

YQEPVLGPVRGPFPI

fermfoodb

FermFooDB_Cheese_FMDB1578

Raw sequence

YQEPVLGPVRGPFPI

fermfoodb

FermFooDB_Cheese_FMDB338

Raw sequence

YQEPVLGPVRGPFPI

satpdb

satpdb14571

Raw sequence

YQEPVLGPVRGPFPI

Citation trail

Literature (4 records)

Lactic Fermentation and Bioactive Peptides

Anne Pihlanto

Lactic Acid Bacteria - R & D for Food, Health and Livestock Purposes Edited by Marcelino Kongo, ISBN 978-953-51-0955-6, 670 pages,2013

Antimicrobial activity of two peptides casecidin 15 and 17, found naturally in bovine colostrum

Birkemo GA, O'Sullivan O, Ross RP, Hill C2009

J Appl Microbiol2009PMID 19054235

-

--PMID 26616950

-

--PMID 21787916

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.254051+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "fermfoodb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCSSSBTTTBTSCC"
}