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PEPDIA-INT-040166

Gold

PAF26

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

RKKWFW

Indexed sequence6 aa

1RKKWFW

Length

Molecular weight

950.16 Da

Formula

C49H67N13O7

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic3

Membrane affinity proxy

Polar0

Solubility proxy

Charged3

Net charge proxy +3

Aromatic3

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

950.1392 Da

Molecular formula

C49H67N13O7

Theoretical pI

11.1663

Net charge at pH 7

2.7581

GRAVY

-1.8833

Instability index

8.3333

Aromaticity

0.5

Topological polar surface area

354.34 Å²

cLogP

1.0343

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

RKKWFW

HELM 2.0

validated simple linear

PEPTIDE1{R.K.K.W.F.W}$$$$V2.0

Canonical SMILES

validated

N=C(N)NCCCC(N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O

Isomeric SMILES

validated

N=C(N)NCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-040166,
  title = {PAF26},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-040166},
  note = {Accessed from local PepDiana development build}
}

APA-style note

PAF26. (2026). PepDiana record PEPDIA-INT-040166. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-040166

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (63 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P040166_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP00141apd / linked
CTPDB_P040166_ACT_apd_0001	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP00141apd / linked
CTPDB_P040166_ACT_camp_0005	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ10837camp / linked
CTPDB_P040166_ACT_camp_0002	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ2731camp / linked
CTPDB_P040166_ACT_camp_0003	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ2731camp / linked
CTPDB_P040166_ACT_camp_0004	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ2731camp / linked
CTPDB_P040166_ACT_cppsite_0006	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2051cppsite / linked
CTPDB_P040166_ACT_dbaasp_0007	Antimicrobial	-	11±1 µM	Penicillium digitatum PHI-26	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0008	Antimicrobial	-	20 µM	Penicillium digitatum PHI-26	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0009	Antimicrobial	-	22±3 µM	Penicillium italicum PHI-1	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0010	Antimicrobial	-	40 µM	Penicillium italicum PHI-1	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0011	Antimicrobial	-	>80 µM	Penicillium expansum CMP-1	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0012	Antimicrobial	-	>160 µM	Penicillium expansum CMP-1	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0013	Antimicrobial	-	38±24 µM	Botrytis cinerea CECT 2100	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0014	Antimicrobial	-	60 µM	Botrytis cinerea CECT 2100	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0015	Antimicrobial	-	45±4 µM	Fusarium oxysporum CECT 2866	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0016	Antimicrobial	-	80 µM	Fusarium oxysporum CECT 2866	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0017	Antimicrobial	-	>80 µM	Saccharomyces cerevisiae W303-1A	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0018	Antimicrobial	-	>160 µM	Saccharomyces cerevisiae W303-1A	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0019	Antimicrobial	-	>80 µM	Escherichia coli DH5alpha	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0020	Antimicrobial	-	160 µM	Escherichia coli DH5alpha	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0021	Antimicrobial	-	2.2±0.3 µM	Penicillium digitatum PHI-26	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0022	Antimicrobial	-	4 µM	Penicillium digitatum PHI-26	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0023	Antimicrobial	-	16 µM	Penicillium digitatum PHI-26	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0024	Antimicrobial	-	2.3 µM	Penicillium italicum PHI-1	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0025	Antimicrobial	-	4 µM	Penicillium italicum PHI-1	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0026	Antimicrobial	-	3.2 µM	Penicillium expansum PHI-65	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0027	Antimicrobial	-	8 µM	Penicillium expansum PHI-65	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0028	Antimicrobial	-	4.6 µM	Alternaria sp. PHI-44	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0029	Antimicrobial	-	8 µM	Alternaria sp. PHI-44	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0030	Antimicrobial	-	3.6 µM	Aspergillus nidulans biA1	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0031	Antimicrobial	-	8 µM	Aspergillus nidulans biA1	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0032	Antimicrobial	-	2.9 µM	Botrytis cinerea #8	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0033	Antimicrobial	-	8 µM	Botrytis cinerea #8	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0034	Antimicrobial	-	4.5 µM	Fusarium oxysporum CECT 2866	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0035	Antimicrobial	-	8 µM	Fusarium oxysporum CECT 2866	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0036	Antimicrobial	-	>32 µM	Pyricularia grisea PR-9	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0037	Antimicrobial	-	20.4 µM	Escherichia coli DH5alpha	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0038	Antimicrobial	-	64 µM	Escherichia coli DH5alpha	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0039	Antimicrobial	-	4.0 µM	Bacillus subtilis CECT 498	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0040	Antimicrobial	-	16 µM	Bacillus subtilis CECT 498	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0041	Antimicrobial	-	15.9 µM	Saccharomyces cerevisiae FY1679	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0042	Antimicrobial	-	32 µM	Saccharomyces cerevisiae FY1679	Not reported by source	DBAASPS_1101_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0043	Antimicrobial	-	2.2±0.2 µM	Penicillium digitatum PHI-26	Not reported by source	DBAASPS_5197_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0044	Antimicrobial	-	4.0 µM	Penicillium digitatum PHI-26	Not reported by source	DBAASPS_5197_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0045	Antimicrobial	-	1.3±0.4 µM	Penicillium digitatum PHI-26	Not reported by source	DBAASPS_5197_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0046	Antimicrobial	-	6.0 µM	Penicillium digitatum PHI-26	Not reported by source	DBAASPS_5197_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0047	Antimicrobial	-	32 µM	Saccharomyces cerevisiae FY1679	Not reported by source	DBAASPS_5197_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0048	Antimicrobial	-	32 µM	Escherichia coli DH5alpha	Not reported by source	DBAASPS_5197_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0049	Antimicrobial	-	125 µg/ml	Candida albicans	Not reported by source	DBAASPS_5197_chain0dbaasp / linked
CTPDB_P040166_ACT_dbaasp_0050	Antimicrobial	-	200 µg/ml	Candida albicans	Not reported by source	DBAASPS_5197_chain0dbaasp / linked
CTPDB_P040166_ACT_dramp_0051	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03998dramp / linked
CTPDB_P040166_ACT_dramp_0052	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP03998dramp / linked
CTPDB_P040166_ACT_dramp_0053	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03998dramp / linked
CTPDB_P040166_ACT_dramp_0054	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP03998dramp / linked
CTPDB_P040166_ACT_hemolytik_0055	Toxicity	Hemolytic	100.0 µM	Erythrocytes	Not reported by source	1721hemolytik / linked
CTPDB_P040166_ACT_satpdb_0056	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb16056satpdb / linked
CTPDB_P040166_ACT_satpdb_0057	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb16056satpdb / linked
CTPDB_P040166_ACT_satpdb_0058	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb16056satpdb / linked
CTPDB_P040166_ACT_satpdb_0059	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb16056satpdb / linked
CTPDB_P040166_ACT_satpdb_0060	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb25324satpdb / linked
CTPDB_P040166_ACT_satpdb_0061	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb25324satpdb / linked
CTPDB_P040166_ACT_satpdb_0062	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb25324satpdb / linked

Provenance

Source database records (10)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

apd

AP00141

Raw sequence

RKKWFW

camp

CAMPSQ2731

Raw sequence

RKKWFW

camp

CAMPSQ10837

Raw sequence

rkkwfw

cppsite

2051

Raw sequence

RKKWFW

dbaasp

DBAASPS_1101_chain0

Raw sequence

rkkwfw

dbaasp

DBAASPS_5197_chain0

Raw sequence

RKKWFW

dramp

DRAMP03998

Raw sequence

RKKWFW

hemolytik

1721

Raw sequence

RKKWFW

satpdb

satpdb16056

Raw sequence

RKKWFW

satpdb

satpdb25324

Raw sequence

RKKWFW

Citation trail

Literature (8 records)

Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library.

López-García B, Pérez-Payá E, Marcos JF

Appl Environ Microbiol2002PMID 11976121

Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library.

López-García B, Pérez-Payá E, Marcos JF

Appl Environ Microbiol2002PMID 17222805

Studies on the mode of action of the antifungal hexapeptide PAF26.

Muñoz A, López-García B, Marcos JF

Antimicrob Agents Chemother2006PMID 17065623

Studies on the mode of action of the antifungal hexapeptide PAF26.

Muñoz A, López-García B, Marcos JF

Antimicrob Agents Chemother2006PMID 17867640

Studies on the mode of action of the antifungal hexapeptide PAF26.

Muñoz A, López-García B, Marcos JF

Antimicrob Agents Chemother2006PMID 34768011

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.941613+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "0% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "0% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cppsite",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCCC"
}