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PEPDIA-INT-039569

Gold

Sequence 2 from Patent US 20030195150

85

Quality

6

Source DBs

26

Activities

21

Source refs

16

Literature

1

Patents

Integrated record

Sequence and molecular profile

TTMPLW
Indexed sequence6 aa
1TTMPLW

Length

6

Molecular weight

747.92 Da

Formula

C35H53N7O9S

Structure type

Linear

Synthesis

Synthetic

Chirality

-

Family

-

Gene

-

Residue composition

T
2
M
1
P
1
L
1
W
1

Physicochemical profile

Hydrophobic3

Membrane affinity proxy

Polar2

Solubility proxy

Charged0

Net charge proxy +0

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

747.9018 Da

Molecular formula

C35H53N7O9S

Theoretical pI

5.185

Net charge at pH 7

-0.6018

GRAVY

0.3

Instability index

121.0333

Aromaticity

0.1667

Topological polar surface area

256.28 Ų

cLogP

-0.3867

Hydrogen-bond donors

9

Hydrogen-bond acceptors

10

Rotatable bonds

19

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

TTMPLW

HELM 2.0

validated simple linear

PEPTIDE1{T.T.M.P.L.W}$$$$V2.0

Canonical SMILES

validated

CSCCC(NC(=O)C(NC(=O)C(N)C(C)O)C(C)O)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O

Isomeric SMILES

validated

CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-039569,
  title = {Sequence 2 from Patent US 20030195150},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-039569},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Sequence 2 from Patent US 20030195150. (2026). PepDiana record PEPDIA-INT-039569. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-039569

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (26 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P039569_ACT_ahtpdb_0003Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source1191ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0004Metabolic/CardiovascularACE Inhibitor16.0 µMUnknownNot reported by source1658ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0005Metabolic/CardiovascularACE Inhibitor16.0 µMUnknownCushman and Cheung (1971)1721ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0006Metabolic/CardiovascularACE Inhibitor22.2 µMUnknownNot reported by source2387ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0007Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source3611ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0000Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownCushman and Cheung (1971)4143ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0001Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4275ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0002Metabolic/CardiovascularACE InhibitorNot available for this observationUnknownNot reported by source4387ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0008Metabolic/CardiovascularACE Inhibitor16.0 µMUnknownCushman and Cheung (1971)5015ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0009Metabolic/CardiovascularACE Inhibitor12.0 µMUnknownNot reported by source5388ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0010Metabolic/CardiovascularACE Inhibitor51.0 µMUnknownNot reported by source5389ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0011Metabolic/CardiovascularACE Inhibitor16.0 µMUnknownNot reported by source5559ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0012Metabolic/CardiovascularACE Inhibitor12.0 µMUnknownCushman and Cheung (1971)5835ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0013Metabolic/CardiovascularACE Inhibitor51.0 µMUnknownCushman and Cheung (1971)5906ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0014Metabolic/CardiovascularACE Inhibitor16.0 µMUnknownNot reported by source6448ahtpdb / linked
CTPDB_P039569_ACT_ahtpdb_0015Metabolic/CardiovascularACE Inhibitor16.0 µMUnknownKasahara and Ashihara (1981)6857ahtpdb / linked
CTPDB_P039569_ACT_camp_0016AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ23412camp / linked
CTPDB_P039569_ACT_camp_0017AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceCAMPSQ23412camp / linked
CTPDB_P039569_ACT_camp_0018AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ23412camp / linked
CTPDB_P039569_ACT_dbaasp_0019Antimicrobial-193 µMEscherichia coli ATCC 11775Not reported by sourceDBAASPS_12518_chain0dbaasp / linked
CTPDB_P039569_ACT_dbaasp_0020Antimicrobial-193 µMStaphylococcus aureus ATCC 12600Not reported by sourceDBAASPS_12518_chain0dbaasp / linked
CTPDB_P039569_ACT_dbaasp_0021Antimicrobial-64 µMMicrococcus luteus ATCC 49732Not reported by sourceDBAASPS_12518_chain0dbaasp / linked
CTPDB_P039569_ACT_dbaasp_0022Antimicrobial-144 µMCandida albicans ATCC 14053Not reported by sourceDBAASPS_12518_chain0dbaasp / linked
CTPDB_P039569_ACT_dramp_0023Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP05052dramp / linked
CTPDB_P039569_ACT_plantpepdb_0024Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownNot reported by sourcePPepDB_194plantpepdb / linked
CTPDB_P039569_ACT_satpdb_0025Metabolic/CardiovascularAntihypertensiveNot available for this observationUnknownNot reported by sourcesatpdb11396satpdb / linked

Provenance

Source database records (21)

ahtpdb

4143

Raw sequence

TTMPLW

ahtpdb

4275

Raw sequence

TTMPLW

ahtpdb

4387

Raw sequence

TTMPLW

ahtpdb

2387

Raw sequence

TTMPLW

ahtpdb

1191

Raw sequence

TTMPLW

ahtpdb

1658

Raw sequence

TTMPLW

ahtpdb

1721

Raw sequence

TTMPLW

ahtpdb

6448

Raw sequence

TTMPLW

ahtpdb

6857

Raw sequence

TTMPLW

ahtpdb

5015

Raw sequence

TTMPLW

ahtpdb

5388

Raw sequence

TTMPLW

ahtpdb

5389

Raw sequence

TTMPLW

ahtpdb

5559

Raw sequence

TTMPLW

ahtpdb

5835

Raw sequence

TTMPLW

ahtpdb

5906

Raw sequence

TTMPLW

ahtpdb

3611

Raw sequence

TTMPLW

camp

CAMPSQ23412

Raw sequence

TTMPLW

dbaasp

DBAASPS_12518_chain0

Raw sequence

TTMPLW

dramp

DRAMP05052

Raw sequence

TTMPLW

plantpepdb

PPepDB_194

Raw sequence

TTMPLW

satpdb

satpdb11396

Raw sequence

TTMPLW

Citation trail

Literature (16 records)

Antihypertensive peptides from food proteins: a review.

Martínez-Maqueda D1, Miralles B, Recio I, Hernández-Ledesma B.

Food Funct. 2012 Apr;3(4):350-61.2012PMID 22249830

Bioactive peptides derived from milk proteins and their health beneficial potentials: an update.

Nagpal R1, Behare P, Rana R, Kumar A, Kumar M, Arora S, Morotta F, Jain S, Yadav H.

Food Funct. 2011 Jan;2(1):18-27.2011PMID 21773582

Impact of milk processing on the generation of peptides during digestion

Kopf-Bolanz, Katrin A.; Schwander, Flurina; Gijs, Martin; Vergeres, Guy; Portmann, Reto; Egger, Lotti

International Dairy Journal (ISSN: 0958-6946), vol. 35, num. 2, p. 130-1382014

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

MILK PROTEINS AS PRECURSORS OF BIOACTIVE PEPTIDES

Marta Dziuba, Bart?omiej Dziuba, Anna Iwaniak

Acta Sci. Pol.,Technol. Aliment. 8(1) 2009,71-902009

Antihypertensive Peptides Specific to Lactobacillus helveticus Fermented Milk

Taketo Wakai and Naoyuki Yamamoto

Biotechnology - Molecular Studies and Novel Applications for Improved Quality of Human Life Edited by Reda Helmy Sammour, ISBN 978-953-51-0151-2, 250 pages2012

Antihypertensive peptides: production, bioavailability and incorporation into foods.

Hernández-Ledesma B1, del Mar Contreras M, Recio I.

Adv Colloid Interface Sci. 2011 Jun 9;165(1):23-352011PMID 21185549

Angiotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein.

Susumu MARUYAMA

Agricultural and Biological Chemistry, ISSN:0002-1369; VOL.53; NO.4; PAGE.1077-10811989

Inhibition of Angiotensin-converting Enzyme by Synthetic Peptides of Human ?-Casein

Masanori KOHMURA et al.

Agric Biol Chem. 53(8):2107-2114.1989

Is the structural diversity of tripeptides sufficient for developing functional food additives with satisfactory multiple bioactivities?

Jian-Hui Wang et al.,

Journal of Molecular Structure 1040 (2013) 164-1702013

Integration of QSAR modelling and QM/MM analysis to investigate functional food peptides with antihypertensive activity

Jin Tan et al.

Molecular Simulation Volume 39, Issue 12, 20132013

12. Functional Food Products with Antihypertensive Effects

Naoyuki Yamamoto

Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals2010

Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine ?S2-casein

Tauzin, J et al.,

FEBS Lett 531 p.369-742002

Angiotensin I Converting Enzyme Inhibitory Peptides Derived from Bovine Milk Proteins (

Pihlanto-Leppälä,A.; Rokka, T.; Korhonen, H.

Int Dairy J 8 p.325-3311998

MOTIFS WITH POTENTIAL PHYSIOLOGICAL ACTIVITY IN FOOD PROTEINS - BIOPEP DATABASE

Iwaniak, Anna; Dziuba, Bartlomiej

Acta Scientiarum Polonorum. Technologia Alimentaria;2009, Vol. 8 Issue 3, p592009

IP evidence

Patents (1)

US 20030195150

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata
[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "source_db": "satpdb",
  "dssp_states": "CCCTTC"
}