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PEPDIA-INT-039051

Gold

TAT(48-57)

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

GRKKRRQRRR

Indexed sequence10 aa

1GRKKRRQRRR

Length

Molecular weight

1396.68 Da

Formula

C55H109N31O12

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic0

Membrane affinity proxy

Polar1

Solubility proxy

Charged8

Net charge proxy +8

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1396.6546 Da

Molecular formula

C55H109N31O12

Theoretical pI

Net charge at pH 7

7.758

GRAVY

-3.87

Instability index

232.7

Aromaticity

Topological polar surface area

791.75 Å²

cLogP

-10.504

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

GRKKRRQRRR

HELM 2.0

validated simple linear

PEPTIDE1{G.R.K.K.R.R.Q.R.R.R}$$$$V2.0

Canonical SMILES

validated

N=C(N)NCCCC(NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(N)=O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)CN)C(=O)O

Isomeric SMILES

validated

N=C(N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-039051,
  title = {TAT(48-57)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-039051},
  note = {Accessed from local PepDiana development build}
}

APA-style note

TAT(48-57). (2026). PepDiana record PEPDIA-INT-039051. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-039051

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (21 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P039051_ACT_camp_0002	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ21821camp / linked
CTPDB_P039051_ACT_cancerppd_0003	Anticancer	Anticancer	Not available in the current structured import	Unknown	LDH leakage assay	4191cancerppd / linked
CTPDB_P039051_ACT_cancerppd_0004	Anticancer	Anticancer	Not available in the current structured import	Unknown	LDH leakage assay	4192cancerppd / linked
CTPDB_P039051_ACT_cancerppd_0005	Anticancer	Anticancer	Not available in the current structured import	Unknown	LDH leakage assay	4193cancerppd / linked
CTPDB_P039051_ACT_cancerppd_0006	Anticancer	Anticancer	Not available in the current structured import	Unknown	LDH leakage assay	4194cancerppd / linked
CTPDB_P039051_ACT_cppsite_0007	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	1005cppsite / linked
CTPDB_P039051_ACT_cppsite_0008	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2475cppsite / linked
CTPDB_P039051_ACT_cppsite_0009	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2558cppsite / linked
CTPDB_P039051_ACT_cppsite_0010	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2559cppsite / linked
CTPDB_P039051_ACT_cppsite_0011	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2677cppsite / linked
CTPDB_P039051_ACT_cppsite_0012	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2678cppsite / linked
CTPDB_P039051_ACT_cppsite_0013	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2822cppsite / linked
CTPDB_P039051_ACT_dbaasp_0014	Antimicrobial	-	94 µg/ml	HIV-1 IIIB	Not reported by source	DBAASPS_6581_chain0dbaasp / linked
CTPDB_P039051_ACT_dramp_0015	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP16375dramp / linked
CTPDB_P039051_ACT_dramp_0016	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP16375dramp / linked
CTPDB_P039051_ACT_hipdb_0000	Antiviral	Anti-HIV	0.094 mg/mL	HIV	Not reported by source	HIPdb_HIP1037hipdb / unavailable
CTPDB_P039051_ACT_hipdb_0001	Antiviral	Anti-HIV	50.0 μM	HIV	Not reported by source	HIPdb_HIP944hipdb / unavailable
CTPDB_P039051_ACT_satpdb_0017	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb15982satpdb / linked
CTPDB_P039051_ACT_satpdb_0018	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb17426satpdb / linked
CTPDB_P039051_ACT_satpdb_0019	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb17426satpdb / linked
CTPDB_P039051_ACT_satpdb_0020	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb17426satpdb / linked

Provenance

Source database records (18)

hipdb

HIPdb_HIP1037

Raw sequence

GRKKRRQRRR

hipdb

HIPdb_HIP944

Raw sequence

GRKKRRQRRR

camp

CAMPSQ21821

Raw sequence

GRKKRRQRRR

cancerppd

4191

Raw sequence

GRKKRRQRRR

cancerppd

4192

Raw sequence

GRKKRRQRRR

cancerppd

4193

Raw sequence

GRKKRRQRRR

cancerppd

4194

Raw sequence

GRKKRRQRRR

cppsite

1005

Raw sequence

GRKKRRQRRR

cppsite

2475

Raw sequence

GRKKRRQRRR

cppsite

2558

Raw sequence

GRKKRRQRRR

cppsite

2559

Raw sequence

GRKKRRQRRR

cppsite

2677

Raw sequence

GRKKRRQRRR

cppsite

2678

Raw sequence

GRKKRRQRRR

cppsite

2822

Raw sequence

GRKKRRQRRR

dbaasp

DBAASPS_6581_chain0

Raw sequence

GRKKRRQRRR

dramp

DRAMP16375

Raw sequence

GRKKRRQRRR

satpdb

satpdb15982

Raw sequence

GRKKRRQRRR

satpdb

satpdb17426

Raw sequence

GRKKRRQRRR

Citation trail

Literature (8 records)

{"pubmed_id": "22319541.0", "paper": "Infection by CXCR4-Tropic Human Immunodeficiency Virus Type 1 Is Inhibited by the Cationic Cell-Penetrating Peptide Derived from HIV-1 Tat.", "authors": "Keogan S, Passic S, Krebs FC.", "reference": "Int J Pept. 2012;2012:349427. Epub 2012 Jan 29."}

{"pubmed_id": "22319541.0", "paper": "Infection by CXCR4-Tropic Human Immunodeficiency Virus Type 1 Is Inhibited by the Cationic Cell-Penetrating Peptide Derived from HIV-1 Tat.", "authors": "Keogan S, Passic S, Krebs FC.", "reference": "Int J Pept. 2012;2012:349427. Epub 2012 Jan 29."}

-

--PMID 22319541

-

--PMID 15467750

{"pubmed_id": "0"}

IP evidence

Patents (1)

US 7432045

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:13.602083+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "hipdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cppsite",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CTTTSSCCCC"
}