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PEPDIA-INT-036958

Gold

Vasoactive intestinal peptide, VIP

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

HSDAVFTDNYTRLRKQMAVKKYLNSILN

Indexed sequence28 aa

1HSDAVFTDNYTRLRKQMAVKKYLNSILN

Length

Molecular weight

3326.84 Da

Formula

C147H237N43O43S

Structure type

Linear

Synthesis

Ribosomal

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic12

Membrane affinity proxy

Polar8

Solubility proxy

Charged8

Net charge proxy +4

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

3326.7815 Da

Molecular formula

C147H237N43O43S

Theoretical pI

9.8209

Net charge at pH 7

2.8445

GRAVY

-0.6393

Instability index

32.1893

Aromaticity

0.1071

Topological polar surface area

1447.9 Å²

cLogP

-14.6169

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

113

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HSDAVFTDNYTRLRKQMAVKKYLNSILN

HELM 2.0

validated simple linear

PEPTIDE1{H.S.D.A.V.F.T.D.N.Y.T.R.L.R.K.Q.M.A.V.K.K.Y.L.N.S.I.L.N}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(N)=O)NC(=O)C(CC(=O)O)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(N)Cc1c[nH]cn1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-036958,
  title = {Vasoactive intestinal peptide, VIP},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-036958},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Vasoactive intestinal peptide, VIP. (2026). PepDiana record PEPDIA-INT-036958. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-036958

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (65 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P036958_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP01477apd / linked
CTPDB_P036958_ACT_apd_0001	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP01477apd / linked
CTPDB_P036958_ACT_camp_0003	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3268camp / linked
CTPDB_P036958_ACT_camp_0004	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3268camp / linked
CTPDB_P036958_ACT_camp_0005	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3268camp / linked
CTPDB_P036958_ACT_dbaasp_0006	Antimicrobial	-	150.7 µg/ml	Streptococcus mutans NCTC 10449	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0007	Antimicrobial	-	>500 µg/ml	Lactobacillus acidophilus NCTC 1723	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0008	Antimicrobial	-	5.2 µg/ml	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0009	Antimicrobial	-	>500 µg/ml	Enterococcus faecalis NCTC 12697	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0010	Antimicrobial	-	4.1 µg/ml	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0011	Antimicrobial	-	>500 µg/ml	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0012	Antimicrobial	-	46.5 µg/ml	Candida albicans NCTC 3179	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0013	Antimicrobial	-	17.5 µg/ml	Escherichia coli ATCC 27325	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0014	Antimicrobial	-	8.5 µg/ml	Pseudomonas aeruginosa ATCC 15692	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0015	Antimicrobial	-	36.87 µg/ml	Streptococcus mutans ATCC 25175	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0016	Antimicrobial	-	NA	Staphylococcus aureus ATCC 6538P	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0017	Antimicrobial	-	30 µg/ml	Escherichia coli ATCC 27325	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0018	Antimicrobial	-	30 µg/ml	Escherichia coli ATCC 27325	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0019	Antimicrobial	-	15 µg/ml	Pseudomonas aeruginosa ATCC 15692	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0020	Antimicrobial	-	15 µg/ml	Pseudomonas aeruginosa ATCC 15692	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0021	Antimicrobial	-	500 µg/ml	Escherichia coli ATCC 27325	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dbaasp_0022	Antimicrobial	-	250 µg/ml	Pseudomonas aeruginosa ATCC 15692	Not reported by source	DBAASPS_4456_chain0dbaasp / linked
CTPDB_P036958_ACT_dramp_0023	Unknown	Not found	Not available in the current structured import	Unknown	Not reported by source	DRAMP03543dramp / linked
CTPDB_P036958_ACT_dramp_0024	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP18166dramp / linked
CTPDB_P036958_ACT_dramp_0025	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP37193dramp / linked
CTPDB_P036958_ACT_dramp_0026	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP37193dramp / linked
CTPDB_P036958_ACT_dramp_0027	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP37193dramp / linked
CTPDB_P036958_ACT_parapep_0028	Antiparasitic	Antiparasitic	Not available in the current structured import	Unknown	MTT assay	1321parapep / linked
CTPDB_P036958_ACT_parapep_0029	Antiparasitic	Antiparasitic	2.8 µM	Unknown	MTT assay	1322parapep / linked
CTPDB_P036958_ACT_peptherdia_0030	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	46peptherdia / linked
CTPDB_P036958_ACT_satpdb_0031	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb20869satpdb / linked
CTPDB_P036958_ACT_satpdb_0032	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb20869satpdb / linked
CTPDB_P036958_ACT_satpdb_0033	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb20869satpdb / linked
CTPDB_P036958_ACT_satpdb_0034	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb25507satpdb / linked
CTPDB_P036958_ACT_satpdb_0035	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb25507satpdb / linked
CTPDB_P036958_ACT_satpdb_0036	Bioregulatory	Cell-Cell Communication	Not available in the current structured import	Unknown	Not reported by source	satpdb25507satpdb / linked
CTPDB_P036958_ACT_satpdb_0037	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb25507satpdb / linked
CTPDB_P036958_ACT_satpdb_0038	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb25507satpdb / linked
CTPDB_P036958_ACT_satpdb_0039	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb25507satpdb / linked
CTPDB_P036958_ACT_topicalpdb_0040	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of number of cups: Control:1.5 , Test:3; Radioactive assay, Measurement of number of cups; in vivo	1267topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0041	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of number of cups: Control:4 , Test:9; Radioactive assay, Measurement of number of cups; in vivo	1268topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0042	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of number of cups: Control:4.5 , Test:7.5; Radioactive assay, Measurement of number of cups; in vivo	1269topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0043	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of number of cups: Control:7 , Test:15; Radioactive assay, Measurement of number of cups; in vivo	1270topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0044	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of E2(Erection): Control:15 , Test:26; Radioactive assay, Measurement of E2(Erection); in vivo	1271topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0045	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of E2(Erection): Control:4 , Test:11; Radioactive assay, Measurement of E2(Erection); in vivo	1272topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0046	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of E2(Erection): Control:6 , Test:12; Radioactive assay, Measurement of E2(Erection); in vivo	1273topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0047	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of E2(Erection): Control:11 , Test:24; Radioactive assay, Measurement of E2(Erection); in vivo	1274topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0048	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of latency of first cup: Control:44 minutes , Test:38 minutes; Radioactive assay, Measurement of latency of first cup; in vivo	1275topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0049	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of latency of first cup: Control:25.5 minutes , Test:19 minutes; Radioactive assay, Measurement of latency of first cup; in vivo	1276topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0050	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of latency of first cup: Control:39 minutes , Test:32 minutes; Radioactive assay, Measurement of latency of first cup; in vivo	1277topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0051	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of latency of first cup: Control:23 minutes , Test:15 minutes; Radioactive assay, Measurement of latency of first cup; in vivo	1278topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0052	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of latency of first E2(Erection): Control:29 minutes , Test:31 minutes; Radioactive assay, Measurement of latency of first E2(Erection); in vivo	1279topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0053	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of latency of first E2(Erection): Control:32 minutes , Test:16 minutes; Radioactive assay, Measurement of latency of first E2(Erection); in vivo	1280topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0054	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of latency of first E2(Erection): Control:9 minutes , Test:3 minutes; Radioactive assay, Measurement of latency of first E2(Erection); in vivo	1281topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0055	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Measurement of latency of first E2(Erection): Control:3.5 minutes , Test:2 minutes; Radioactive assay, Measurement of latency of first E2(Erection); in vivo	1282topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0056	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	0.6% of the applied material was found in the penile tissue; Labelled peptide was detected and quantified by measuring radioactivity in a gamma counter; in vivo	1348topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0057	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	5% of the applied material was found in the penile tissue; Labelled peptide was detected and quantified by measuring radioactivity in a gamma counter; in vivo	1349topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0058	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	2.5% of the applied material was found in the penile tissue; Labelled peptide was detected and quantified by measuring radioactivity in a gamma counter; in vivo	1350topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0059	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	1.25% of the applied material was found in the penile tissue; Labelled peptide was detected and quantified by measuring radioactivity in a gamma counter; in vivo	1351topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0060	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Approximately 0.6% incorporation per 10 ml blood as a percentage of the total radioactivity applied; Radiolabelling assay is used to determine incorporation per 10 ml blood as a percentage of the total radioactivity applied using gamma counter.; in vivo	1352topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0061	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Approximately 0.55% incorporation per 10 ml blood as a percentage of the total radioactivity applied; Radiolabelling assay is used to determine incorporation per 10 ml blood as a percentage of the total radioactivity applied using gamma counter.; in vivo	1353topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0062	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Approximately 0.4% incorporation per 10 ml blood as a percentage of the total radioactivity applied; Radiolabelling assay is used to determine incorporation per 10 ml blood as a percentage of the total radioactivity applied using gamma counter.; in vivo	1354topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0063	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Osmolarity measurements: t=0 min., VIP/Buffer=330/314.5mOsm/l; t=16 min., VIP/Buffer=315/313.5mOsm/l; Tear film osmolarity; in vivo	1425topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0064	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Osmolarity measurements: t=0 min., VIP/Buffer=320/318mOsm/l; t=6 min., VIP/Buffer=303.5/310mOsm/l; t=16 min., VIP/Buffer=310/314mOsm/l; Tear film osmolarity; in vivo	1426topicalpdb / linked
CTPDB_P036958_ACT_topicalpdb_0065	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Osmolarity measurements: t=0 min., VIP/Buffer=315/320mOsm/l; t=6 min., VIP/Buffer=301/314mOsm/l; t=16 min., VIP/Buffer=308/313mOsm/l; Volume measurement: VIP/Buffer= 17µl/7µl; Osmolarity and tear volume measurements; in vivo	1427topicalpdb / linked

Provenance

Source database records (44)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

apd

AP01477

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

b3pdb

b3pdb_0438

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

b3pdb

b3pdb_0439

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

b3pdb

b3pdb_0440

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

b3pdb

b3pdb_0441

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

b3pdb

b3pdb_0442

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

b3pdb

b3pdb_0443

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

b3pdb

b3pdb_0444

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

camp

CAMPSQ3268

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

dbaasp

DBAASPS_4456_chain0

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

dramp

DRAMP03543

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

dramp

DRAMP18166

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

dramp

DRAMP37193

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

parapep

1321

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

parapep

1322

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

peptherdia

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

satpdb

satpdb20869

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

satpdb

satpdb25507

Raw sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

topicalpdb

1267

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1268

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1269

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1270

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1271

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1272

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1273

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1274

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1275

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1276

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1277

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1278

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1279

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1280

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1281

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1282

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1348

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1349

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1350

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1351

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1352

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1353

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1354

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1425

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1426

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

topicalpdb

1427

Raw sequence

HSDAVFTDNYTRLR KQMAVKKYLNSILN

Citation trail

Literature (11 records)

{"reference": "J Neuroimmunol. 2008 Aug 30;200(1-2):11-6", "title": "Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites.", "author": "El Karim IA, Linden GJ, Orr DF, Lundy FT.2008"}

{"reference": "J Neuroimmunol. 2008 Aug 30;200(1-2):11-6", "title": "Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites.", "author": "El Karim IA, Linden GJ, Orr DF, Lundy FT.2008"}

-

--PMID 12732342

-

--PMID 18603306

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites.

El Karim IA, Linden GJ, Orr DF, Lundy FT

J Neuroimmunol2008PMID 21176972

-

--PMID 8466684

{"doi": "10.13345/j.cjb.170506.", "reference": "[J].生物工程学报,2018,34(06):1002-1011.DOI:10.13345/j.cjb.170506.", "author": "乔想金,李文新,白丽娟:Xiangjin Qiao,Wnxin Li,Lijun Bai,Wei Hu,Huai Nan", "title": "抗菌肽VIP在毕赤酵母中的高效表达及鉴定; Expression and identification of an antimicrobial peptide VlP in Pichiapastoris"}

{"doi": "10.13345/j.cjb.170506.", "reference": "[J].生物工程学报,2018,34(06):1002-1011.DOI:10.13345/j.cjb.170506.", "author": "乔想金,李文新,白丽娟:Xiangjin Qiao,Wnxin Li,Lijun Bai,Wei Hu,Huai Nan", "title": "抗菌肽VIP在毕赤酵母中的高效表达及鉴定; Expression and identification of an antimicrobial peptide VlP in Pichiapastoris"}

-

--PMID 19057622

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB06260", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB06260)"}, {"text": "mims.co.uk", "url": "https://www.mims.co.uk/aviptadil-phentolamine-launched-combination-treatment-erectile-dysfunction/mens-health/article/1370338", "markdown": "[mims.co.uk](https://www.mims.co.uk/aviptadil-phentolamine-launched-combination-treatment-erectile-dysfunction/mens-health/article/1370338)"}, {"text": "nice.org.uk", "url": "https://b

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB06260", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB06260)"}, {"text": "mims.co.uk", "url": "https://www.mims.co.uk/aviptadil-phentolamine-launched-combination-treatment-erectile-dysfunction/mens-health/article/1370338", "markdown": "[mims.co.uk](https://www.mims.co.uk/aviptadil-phentolamine-launched-combination-treatment-erectile-dysfunction/mens-health/article/1370338)"}, {"text": "nice.org.uk", "url": "https://b

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.491115+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "10% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human pulp fibroblasts"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "b3pdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "peptherdia",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "topicalpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "pdb_id": [
    "2RRH",
    "Not found"
  ],
  "source_db": "dramp"
}

Clinical trials

[
  {
    "status": "Therapeutic (orphan)",
    "drug_name": "Aviptadil",
    "source_db": "peptherdia",
    "indication": "Erectile dysfunction (in combination with phentolamine)",
    "approval_year": 2000,
    "approval_agency": "MedSafe",
    "administration_route": "Intracavernous injection"
  }
]

Approved drug annotations

{
  "status": "Therapeutic (orphan)",
  "drug_name": "Aviptadil",
  "source_db": "peptherdia",
  "indication": "Erectile dysfunction (in combination with phentolamine)",
  "approval_year": 2000,
  "approval_agency": "MedSafe",
  "administration_route": "Intracavernous injection"
}