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PEPDIA-INT-035247

Gold

Tat-13

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

GRKKRRQRRRPPQ

Indexed sequence13 aa

1GRKKRRQRRRPPQ

Length

Molecular weight

1719.05 Da

Formula

C70H131N35O16

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic0

Membrane affinity proxy

Polar2

Solubility proxy

Charged8

Net charge proxy +8

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1719.0142 Da

Molecular formula

C70H131N35O16

Theoretical pI

Net charge at pH 7

7.758

GRAVY

-3.4923

Instability index

225.7538

Aromaticity

Topological polar surface area

904.56 Å²

cLogP

-11.7717

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

GRKKRRQRRRPPQ

HELM 2.0

validated simple linear

PEPTIDE1{G.R.K.K.R.R.Q.R.R.R.P.P.Q}$$$$V2.0

Canonical SMILES

validated

N=C(N)NCCCC(NC(=O)CN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)O

Isomeric SMILES

validated

N=C(N)NCCC[C@H](NC(=O)CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-035247,
  title = {Tat-13},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-035247},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Tat-13. (2026). PepDiana record PEPDIA-INT-035247. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-035247

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (37 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P035247_ACT_camp_0000	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ13558camp / linked
CTPDB_P035247_ACT_camp_0001	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ13558camp / linked
CTPDB_P035247_ACT_cppsite_0002	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	1001cppsite / linked
CTPDB_P035247_ACT_cppsite_0003	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	1216cppsite / linked
CTPDB_P035247_ACT_cppsite_0004	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	1748cppsite / linked
CTPDB_P035247_ACT_cppsite_0005	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	1805cppsite / linked
CTPDB_P035247_ACT_cppsite_0006	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2173cppsite / linked
CTPDB_P035247_ACT_cppsite_0007	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2494cppsite / linked
CTPDB_P035247_ACT_cppsite_0008	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2589cppsite / linked
CTPDB_P035247_ACT_cppsite_0009	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2600cppsite / linked
CTPDB_P035247_ACT_cppsite_0010	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2816cppsite / linked
CTPDB_P035247_ACT_cppsite_0011	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2830cppsite / linked
CTPDB_P035247_ACT_cppsite_0012	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2832cppsite / linked
CTPDB_P035247_ACT_cppsite_0013	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2841cppsite / linked
CTPDB_P035247_ACT_cppsite_0014	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2897cppsite / linked
CTPDB_P035247_ACT_dbaasp_0015	Antimicrobial	-	>256 µM	Staphylococcus aureus ATCC 33591	Not reported by source	DBAASPS_8813_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0016	Antimicrobial	-	256 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_8813_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0017	Antimicrobial	-	849±77.8 µM	Human cervical carcinoma HeLa	Not reported by source	DBAASPS_8813_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0018	Antimicrobial	-	2 µM	Escherichia coli KCTC 1682	Not reported by source	DBAASPS_9244_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0019	Antimicrobial	-	4 µM	Pseudomonas aeruginosa KCTC 1637	Not reported by source	DBAASPS_9244_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0020	Antimicrobial	-	8 µM	Salmonella typhimurium KCTC 1926	Not reported by source	DBAASPS_9244_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0021	Antimicrobial	-	4 µM	Bacillus subtilis KCTC 3068	Not reported by source	DBAASPS_9244_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0022	Antimicrobial	-	4 µM	Staphylococcus epidermidis KCTC 1917	Not reported by source	DBAASPS_9244_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0023	Antimicrobial	-	4 µM	Staphylococcus aureus KCTC 1621	Not reported by source	DBAASPS_9244_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0024	Antimicrobial	-	>128 µM	Escherichia coli DSM 1103	Not reported by source	DBAASPS_9244_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0025	Antimicrobial	-	128 µM	Pseudomonas aeruginosa DSM 1117	Not reported by source	DBAASPS_9244_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0026	Antimicrobial	-	128 µM	Staphylococcus aureus DSM 1104	Not reported by source	DBAASPS_9244_chain0dbaasp / linked
CTPDB_P035247_ACT_dbaasp_0027	Antimicrobial	-	>128 µM	Staphylococcus epidermidis DSM 1798	Not reported by source	DBAASPS_9244_chain0dbaasp / linked
CTPDB_P035247_ACT_dramp_0028	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP17285dramp / linked
CTPDB_P035247_ACT_hemolytik_0029	Toxicity	Hemolytic	50.0 µM	Erythrocytes	Not reported by source	1644hemolytik / linked
CTPDB_P035247_ACT_satpdb_0030	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb12221satpdb / linked
CTPDB_P035247_ACT_satpdb_0031	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb14864satpdb / linked
CTPDB_P035247_ACT_satpdb_0032	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb17839satpdb / linked
CTPDB_P035247_ACT_satpdb_0033	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb17839satpdb / linked
CTPDB_P035247_ACT_satpdb_0034	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb23889satpdb / linked
CTPDB_P035247_ACT_topicalpdb_0035	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Kp (permeability coefficients) 6.30 in the cubic system; Franz cell system; in vitro	1111topicalpdb / linked
CTPDB_P035247_ACT_topicalpdb_0036	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Kp (permeability coefficients) 1.70 in the cubic system; Franz cell system; in vitro	1112topicalpdb / linked

Provenance

Source database records (24)

camp

CAMPSQ13558

Raw sequence

GRKKRRQRRRPPQ

cppsite

1001

Raw sequence

GRKKRRQRRRPPQ

cppsite

1216

Raw sequence

GRKKRRQRRRPPQ

cppsite

1748

Raw sequence

GRKKRRQRRRPPQ

cppsite

1805

Raw sequence

GRKKRRQRRRPPQ

cppsite

2173

Raw sequence

GRKKRRQRRRPPQ

cppsite

2494

Raw sequence

GRKKRRQRRRPPQ

cppsite

2589

Raw sequence

GRKKRRQRRRPPQ

cppsite

2600

Raw sequence

GRKKRRQRRRPPQ

cppsite

2816

Raw sequence

GRKKRRQRRRPPQ

cppsite

2830

Raw sequence

GRKKRRQRRRPPQ

cppsite

2832

Raw sequence

GRKKRRQRRRPPQ

cppsite

2841

Raw sequence

GRKKRRQRRRPPQ

cppsite

2897

Raw sequence

GRKKRRQRRRPPQ

dbaasp

DBAASPS_8813_chain0

Raw sequence

GRKKRRQRRRPPQ

dbaasp

DBAASPS_9244_chain0

Raw sequence

GRKKRRQRRRPPQ

dramp

DRAMP17285

Raw sequence

GRKKRRQRRRPPQ

hemolytik

1644

Raw sequence

GRKKRRQRRRPPQ

satpdb

satpdb12221

Raw sequence

GRKKRRQRRRPPQ

satpdb

satpdb14864

Raw sequence

GRKKRRQRRRPPQ

satpdb

satpdb17839

Raw sequence

GRKKRRQRRRPPQ

satpdb

satpdb23889

Raw sequence

GRKKRRQRRRPPQ

topicalpdb

1111

Raw sequence

GRKKRRQRRRPPQ

topicalpdb

1112

Raw sequence

GRKKRRQRRRPPQ

Citation trail

Literature (17 records)

{"pubmed_id": "0"}

-

--PMID 15937518

-

--PMID 25016968

-

--PMID 24798650

-

--PMID 21575694

-

--PMID 23707662

-

--PMID 23603097

-

--PMID 23585561

-

--PMID 25459448

Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure.

Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM

Biochim Biophys Acta2013PMID 23085001

Effects of dimerization of the cell-penetrating peptide Tat analog on antimicrobial activity and mechanism of bactericidal action.

Zhu WL, Shin SY

J Pept Sci2009PMID 19206074

Effects of dimerization of the cell-penetrating peptide Tat analog on antimicrobial activity and mechanism of bactericidal action.

Zhu WL, Shin SY

J Pept Sci2009PMID 22853904

-

--PMID 16137634

-

--PMID 19733297

IP evidence

Patents (1)

US 20100279918

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:15.080433+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": ">200",
      "source_db": "dbaasp",
      "assay_method": "5% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cppsite",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "topicalpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CGGGCCCSSCSCC"
}