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PEPDIA-INT-035008

Gold

Conolysin-Mt

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

FHPSLWVLIPQYIQLIRKILKSG

Indexed sequence23 aa

1FHPSLWVLIPQYIQLIRKILKSG

Length

Molecular weight

2750.38 Da

Formula

C134H213N33O29

Structure type

Linear

Synthesis

Ribosomal

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic12

Membrane affinity proxy

Polar4

Solubility proxy

Charged4

Net charge proxy +4

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

2750.3283 Da

Molecular formula

C134H213N33O29

Theoretical pI

10.2897

Net charge at pH 7

2.8443

GRAVY

0.4478

Instability index

28.1261

Aromaticity

0.1304

Topological polar surface area

991.22 Å²

cLogP

-2.3498

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

FHPSLWVLIPQYIQLIRKILKSG

HELM 2.0

validated simple linear

PEPTIDE1{F.H.P.S.L.W.V.L.I.P.Q.Y.I.Q.L.I.R.K.I.L.K.S.G}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C1CCCN1C(=O)C(Cc1c[nH]cn1)NC(=O)C(N)Cc1ccccc1)C(C)C)C(C)CC)C(C)CC)C(C)CC)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NCC(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCC(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-035008,
  title = {Conolysin-Mt},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-035008},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Conolysin-Mt. (2026). PepDiana record PEPDIA-INT-035008. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-035008

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (25 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P035008_ACT_camp_0000	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ1056camp / linked
CTPDB_P035008_ACT_camp_0001	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ1056camp / linked
CTPDB_P035008_ACT_dbaasp_0002	Antimicrobial	-	>50 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0003	Antimicrobial	-	>50 µM	Escherichia coli D21	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0004	Antimicrobial	-	25-50 µM	Staphylococcus aureus ATCC 6538	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0005	Antimicrobial	-	9.21±1.20 µM	Mouse skin melanoma B16-F10	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0006	Antimicrobial	-	4.12±0.76 µM	Human pancreatic adenocarcinoma BxPC-3	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0007	Antimicrobial	-	1.11±0.09 µM	Human myelogenous leukemia K562	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0008	Antimicrobial	-	13.46±2.58 µM	Human pancreatic carcinoma Panc-1	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0009	Antimicrobial	-	1.29±0.04 µM	Human cervical carcinoma HeLa	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0010	Antimicrobial	-	2.23±0.24 µM	Human colon adenocarcinoma HCT 116	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0011	Antimicrobial	-	3.18±0.62 µM	Human pancreatic carcinoma Mia PaCa-2	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0012	Antimicrobial	-	3.45±0.18 µM	Mouse breast cancer 4T1	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0013	Antimicrobial	-	10.27±5.27 µM	Human hepatocellular carcinoma HepG2	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0014	Antimicrobial	-	10.62±5.27 µM	Human glioblastoma U251-MG	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0015	Antimicrobial	-	8.18±0.25 µM	Rat pheochromocytoma PC12	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dbaasp_0016	Antimicrobial	-	1.09±0.11 µM	Human lung carcinoma A549	Not reported by source	DBAASPS_3006_chain0dbaasp / linked
CTPDB_P035008_ACT_dramp_0017	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP02813dramp / linked
CTPDB_P035008_ACT_dramp_0018	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP02813dramp / linked
CTPDB_P035008_ACT_dramp_0019	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP02813dramp / linked
CTPDB_P035008_ACT_hemolytik_0020	Toxicity	Hemolytic	1.0 µM	Erythrocytes	Not reported by source	3635hemolytik / linked
CTPDB_P035008_ACT_hemolytik_0021	Toxicity	Hemolytic	10.0 µM	Erythrocytes	Not reported by source	3636hemolytik / linked
CTPDB_P035008_ACT_satpdb_0022	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb12170satpdb / linked
CTPDB_P035008_ACT_satpdb_0023	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb12170satpdb / linked
CTPDB_P035008_ACT_satpdb_0024	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb12170satpdb / linked

Provenance

Source database records (7)

camp

CAMPSQ1056

Raw sequence

FHPSLWVLIPQYIQLIRKILKSG

conoserver

P02746

Raw sequence

FHPSLWVLIPQYIQLIRKILKSG

dbaasp

DBAASPS_3006_chain0

Raw sequence

FHPSLWVLIPQYIQLIRKILKSG

dramp

DRAMP02813

Raw sequence

FHPSLWVLIPQYIQLIRKILKSG

hemolytik

3635

Raw sequence

FHPSLWVLIPQYIQLIRKILKSG

hemolytik

3636

Raw sequence

FHPSLWVLIPQYIQLIRKILKSG

satpdb

satpdb12170

Raw sequence

FHPSLWVLIPQYIQLIRKILKSG

Citation trail

Literature (2 records)

-

--PMID 17927208

Conolysin-Mt: a conus peptide that disrupts cellular membranes

Biggs JS, Rosenfeld Y, Shai Y, Olivera BM

Biochemistry2007PMID 39706427

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:13.664756+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "1",
      "source_db": "dbaasp",
      "assay_method": "40% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "10",
      "source_db": "dbaasp",
      "assay_method": "90% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "2.85±0.29",
      "source_db": "dbaasp",
      "assay_method": "IC50",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human pancreas epithelial cells HPNE"
    },
    {
      "unit": "µM",
      "value": "1.32±0.06",
      "source_db": "dbaasp",
      "assay_method": "IC50",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human umbilical vein endothelial cells HUVEC"
    },
    {
      "unit": "µM",
      "value": "4.70±0.20",
      "source_db": "dbaasp",
      "assay_method": "IC50",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human keratinocytes HaCat"
    },
    {
      "unit": "µM",
      "value": "7.29±0.69",
      "source_db": "dbaasp",
      "assay_method": "IC50",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human embryonic kidney HEK293T cells"
    },
    {
      "unit": "µM",
      "value": "25",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.17927208]95% hemolytic activity at 25 μM against human red blood cells",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "conoserver",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCHHHHTSHHHHHHHHHHHHTCC"
}