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PEPDIA-INT-034762

Gold

α-conotoxin RgIA[R7,9,11r]

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

GCCSDPRCRYRC

Indexed sequence12 aa

1GCCSDPRCRYRC

Length

Molecular weight

1418.68 Da

Formula

C53H87N21O17S4

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar5

Solubility proxy

Charged4

Net charge proxy +2

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1418.6484 Da

Molecular formula

C53H87N21O17S4

Theoretical pI

8.5495

Net charge at pH 7

1.7206

GRAVY

-0.925

Instability index

-17.4917

Aromaticity

0.0833

Topological polar surface area

638.09 Å²

cLogP

-9.207

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

GCCSDPRCRYRC

HELM 2.0

validated simple linear

PEPTIDE1{G.C.C.S.D.P.R.C.R.Y.R.C}$$$$V2.0

Canonical SMILES

validated

N=C(N)NCCCC(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCNC(=N)N)NC(=O)C(CS)NC(=O)C(CCCNC(=N)N)NC(=O)C1CCCN1C(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CS)NC(=O)C(CS)NC(=O)CN)C(=O)NC(CS)C(=O)O

Isomeric SMILES

validated

N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@@H](CS)C(=O)O

Follow-up research

External analysis tools

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-034762,
  title = {α-conotoxin RgIA[R7,9,11r]},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-034762},
  note = {Accessed from local PepDiana development build}
}

APA-style note

α-conotoxin RgIA[R7,9,11r]. (2026). PepDiana record PEPDIA-INT-034762. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-034762

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (7 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P034762_ACT_conoserver_0000	Neuroactive/Ion Channel	Toxin	Not available in the current structured import	Nicotinic acetylcholine receptors	Not reported by source	P07466conoserver / linked
CTPDB_P034762_ACT_conoserver_0001	Neuroactive/Ion Channel	Toxin	Not available in the current structured import	Nicotinic acetylcholine receptors	Not reported by source	P07466conoserver / linked
CTPDB_P034762_ACT_dbaasp_0002	Antimicrobial	-	128 µM	Candida tropicalis BNCC 340288	Not reported by source	DBAASPS_22119_chain0dbaasp / linked
CTPDB_P034762_ACT_dbaasp_0003	Antimicrobial	-	>128 µM	Candida parapsilosis BNCC 336015	Not reported by source	DBAASPS_22119_chain0dbaasp / linked
CTPDB_P034762_ACT_dbaasp_0004	Antimicrobial	-	>128 µM	Bacillus subtilis BNCC 109047	Not reported by source	DBAASPS_22119_chain0dbaasp / linked
CTPDB_P034762_ACT_dbaasp_0005	Antimicrobial	-	>128 µM	Escherichia coli BNCC 336902	Not reported by source	DBAASPS_22119_chain0dbaasp / linked
CTPDB_P034762_ACT_satpdb_0006	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb17236satpdb / linked

Provenance

Source database records (3)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

conoserver

P07466

Raw sequence

GCCSDPRCRYRC(nh2)

dbaasp

DBAASPS_22119_chain0

Raw sequence

GCCSDPrCrYrC

satpdb

satpdb17236

Raw sequence

GCCSDPRCRYRC

Citation trail

Literature (3 records)

-

--PMID 21888386

-

--PMID 32101438

Engineering Enhanced Antimicrobial Properties in α-Conotoxin RgIA through D-Type Amino Acid Substitution and Incorporation of Lysine and Leucine Residues.

Wang M, Liao Z, Zhangsun D, Wu Y, Luo S

Molecules2024PMID 38474693

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:17.416148+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "conoserver",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSCCSSSSCCC"
}