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PEPDIA-INT-034513

Gold

Brevinin-1E

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

FLPLLAGLAANFLPKIFCKITRKC

Indexed sequence24 aa

1FLPLLAGLAANFLPKIFCKITRKC

Length

Molecular weight

Formula

Structure type

Cyclic

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic13

Membrane affinity proxy

Polar4

Solubility proxy

Charged4

Net charge proxy +4

Aromatic3

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

partial sequence only structural context

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

2678.3502 Da

Molecular formula

Not calculated

Theoretical pI

9.8507

Net charge at pH 7

3.7373

GRAVY

0.95

Instability index

12.2958

Aromaticity

0.125

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

not generated modification context

Not calculated for this record

HELM 2.0

not generated modification context

Not calculated for this record

Canonical SMILES

not generated modification context

Not calculated for this record

Isomeric SMILES

not generated modification context

Not calculated for this record

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-034513,
  title = {Brevinin-1E},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-034513},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Brevinin-1E. (2026). PepDiana record PEPDIA-INT-034513. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-034513

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (53 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P034513_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP00073apd / linked
CTPDB_P034513_ACT_apd_0001	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP00073apd / linked
CTPDB_P034513_ACT_apd_0003	Metabolic/Cardiovascular	Antidiabetic	Not available in the current structured import	Unknown	Not reported by source	AP00073apd / linked
CTPDB_P034513_ACT_apd_0004	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	AP00073apd / linked
CTPDB_P034513_ACT_camp_0005	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ1765camp / linked
CTPDB_P034513_ACT_camp_0006	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ1765camp / linked
CTPDB_P034513_ACT_camp_0007	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ4355camp / linked
CTPDB_P034513_ACT_camp_0008	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ598camp / linked
CTPDB_P034513_ACT_camp_0009	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ598camp / linked
CTPDB_P034513_ACT_dbaasp_0010	Antimicrobial	-	1.8 µM	Escherichia coli D21	Not reported by source	DBAASPS_1077_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0011	Antimicrobial	-	0.4 µM	Bacillus megaterium Bm11	Not reported by source	DBAASPS_1077_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0012	Antimicrobial	-	0.6 µM	Staphylococcus aureus Cowan 1	Not reported by source	DBAASPS_1077_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0013	Antimicrobial	-	30.6 µM	Pseudomonas aeruginosa ATCC 15692	Not reported by source	DBAASPS_1077_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0014	Antimicrobial	-	4.7 µM	Candida albicans	Not reported by source	DBAASPS_1077_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0015	Antimicrobial	-	3.8 µM	Saccharomyces cerevisiae	Not reported by source	DBAASPS_1077_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0016	Antimicrobial	-	20 µM	Escherichia coli	Not reported by source	DBAASPS_1077_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0017	Antimicrobial	-	2 µM	Staphylococcus aureus	Not reported by source	DBAASPS_1077_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0018	Antimicrobial	-	6.25 µg/ml	Staphylococcus aureus ATCC 6538	Not reported by source	DBAASPS_5759_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0019	Antimicrobial	-	6.25 µg/ml	Staphylococcus aureus	Not reported by source	DBAASPS_5759_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0020	Antimicrobial	-	3.12 µg/ml	Micrococcus luteus ATCC 9341	Not reported by source	DBAASPS_5759_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0021	Antimicrobial	-	6.25 µg/ml	Escherichia coli ATCC 2592	Not reported by source	DBAASPS_5759_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0022	Antimicrobial	-	3.12 µg/ml	Pseudomonas aeruginosa ATCC 9027	Not reported by source	DBAASPS_5759_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0023	Antimicrobial	-	>100 µg/ml	Proteus vulgaris ATCC 6380	Not reported by source	DBAASPS_5759_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0024	Antimicrobial	-	3.12 µg/ml	Candida albicans ATCC 36232	Not reported by source	DBAASPS_5759_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0025	Antimicrobial	-	6.25 µg/ml	Staphylococcus aureus ATCC 6538	Not reported by source	DBAASPS_5760_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0026	Antimicrobial	-	6.25 µg/ml	Staphylococcus aureus	Not reported by source	DBAASPS_5760_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0027	Antimicrobial	-	3.12 µg/ml	Micrococcus luteus ATCC 9341	Not reported by source	DBAASPS_5760_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0028	Antimicrobial	-	6.25 µg/ml	Escherichia coli ATCC 2592	Not reported by source	DBAASPS_5760_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0029	Antimicrobial	-	3.12 µg/ml	Pseudomonas aeruginosa ATCC 9027	Not reported by source	DBAASPS_5760_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0030	Antimicrobial	-	>100 µg/ml	Proteus vulgaris ATCC 6380	Not reported by source	DBAASPS_5760_chain0dbaasp / linked
CTPDB_P034513_ACT_dbaasp_0031	Antimicrobial	-	3.12 µg/ml	Candida albicans ATCC 36232	Not reported by source	DBAASPS_5760_chain0dbaasp / linked
CTPDB_P034513_ACT_dramp_0032	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP02081dramp / linked
CTPDB_P034513_ACT_dramp_0033	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP02081dramp / linked
CTPDB_P034513_ACT_dramp_0034	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP02081dramp / linked
CTPDB_P034513_ACT_dramp_0035	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP02081dramp / linked
CTPDB_P034513_ACT_dramp_0036	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP02081dramp / linked
CTPDB_P034513_ACT_dramp_0037	Unknown	Anti Mammalian Cells	Not available in the current structured import	Unknown	Not reported by source	DRAMP02081dramp / linked
CTPDB_P034513_ACT_dramp_0038	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP05617dramp / linked
CTPDB_P034513_ACT_hemolytik_0044	Toxicity	Hemolytic	10.0 µg/ml	Erythrocytes	Not reported by source	1602hemolytik / linked
CTPDB_P034513_ACT_hemolytik_0045	Toxicity	Hemolytic	100.0 µg/ml	Erythrocytes	Not reported by source	1606hemolytik / linked
CTPDB_P034513_ACT_hemolytik_0039	Toxicity	Hemolytic	0.7 µM	Erythrocytes	Not reported by source	2147hemolytik / linked
CTPDB_P034513_ACT_hemolytik_0040	Toxicity	Hemolytic	1.1 µg/ml	Erythrocytes	Not reported by source	3285hemolytik / linked
CTPDB_P034513_ACT_hemolytik_0041	Toxicity	Hemolytic	1.6 µg/ml	Erythrocytes	Not reported by source	3286hemolytik / linked
CTPDB_P034513_ACT_hemolytik_0042	Toxicity	Hemolytic	0.5 µM	Erythrocytes	Not reported by source	3302hemolytik / linked
CTPDB_P034513_ACT_hemolytik_0043	Toxicity	Hemolytic	5.0 µM	Erythrocytes	Not reported by source	3683hemolytik / linked
CTPDB_P034513_ACT_satpdb_0046	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb12342satpdb / linked
CTPDB_P034513_ACT_satpdb_0047	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb12342satpdb / linked
CTPDB_P034513_ACT_satpdb_0048	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb12342satpdb / linked
CTPDB_P034513_ACT_satpdb_0049	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb15685satpdb / linked
CTPDB_P034513_ACT_satpdb_0050	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb15685satpdb / linked
CTPDB_P034513_ACT_satpdb_0051	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb15685satpdb / linked
CTPDB_P034513_ACT_satpdb_0052	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb28889satpdb / linked
CTPDB_P034513_ACT_satpdb_0053	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb28889satpdb / linked

Provenance

Source database records (19)

apd

AP00073

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

camp

CAMPSQ1765

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

camp

CAMPSQ4355

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

camp

CAMPSQ598

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

dbaasp

DBAASPS_1077_chain0

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

dbaasp

DBAASPS_5759_chain0

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

dbaasp

DBAASPS_5760_chain0

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

dramp

DRAMP02081

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

dramp

DRAMP05617

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

hemolytik

2147

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

hemolytik

3285

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

hemolytik

3286

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

hemolytik

3302

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

hemolytik

3683

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

hemolytik

1602

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

hemolytik

1606

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

satpdb

satpdb12342

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

satpdb

satpdb15685

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

satpdb

satpdb28889

Raw sequence

FLPLLAGLAANFLPKIFCKITRKC

Citation trail

Literature (6 records)

Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.

Simmaco M, Mignogna G, Barra D, Bossa F.1994

J Biol Chem1994PMID 8163497

-

--PMID 16394170

-

--PMID 8508915

Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta

Simmaco M, Mignogna G, Barra D, Bossa F

FEBS Lett1993PMID 11892852

Structure-activity analysis of brevinin 1E amide, an antimicrobial peptide from Rana esculenta.

Kwon M, Hong SY, Lee KH

Biochim Biophys Acta1998PMID 9748603

-

--PMID 15232222

IP evidence

Patents (1)

US 20050260715

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.941613+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "0.5",
      "source_db": "dbaasp",
      "assay_method": "100% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "0.7",
      "source_db": "dbaasp",
      "assay_method": "100% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Rat erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "1.1",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "1.6",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.8163497] LC50=0.5 µM against human red blood cell.",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CBSCTTSTTTBCTTTTTSTTCCCC"
}