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PEPDIA-INT-034101

Gold

RW4

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

RWRWRWRW

Indexed sequence8 aa

1RWRWRWRW

Length

Molecular weight

1387.63 Da

Formula

C68H90N24O9

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar0

Solubility proxy

Charged4

Net charge proxy +4

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1387.5977 Da

Molecular formula

C68H90N24O9

Theoretical pI

Net charge at pH 7

3.7601

GRAVY

-2.7

Instability index

295.15

Aromaticity

0.5

Topological polar surface area

577.78 Å²

cLogP

-0.259

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

RWRWRWRW

HELM 2.0

validated simple linear

PEPTIDE1{R.W.R.W.R.W.R.W}$$$$V2.0

Canonical SMILES

validated

N=C(N)NCCCC(N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O

Isomeric SMILES

validated

N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-034101,
  title = {RW4},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-034101},
  note = {Accessed from local PepDiana development build}
}

APA-style note

RW4. (2026). PepDiana record PEPDIA-INT-034101. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-034101

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (28 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P034101_ACT_avpdb_0000	Antiviral	General Antiviral	Nil	Vaccinia	Plaque assay	AVPdb_AVP1532avpdb / unavailable
CTPDB_P034101_ACT_baamps_0001	Antimicrobial	Anti-Biofilm	Not available in the current structured import	Unknown	Not reported by source	EXP00235baamps / linked
CTPDB_P034101_ACT_baamps_0002	Antimicrobial	Anti-Biofilm	Not available in the current structured import	Unknown	Not reported by source	EXP00236baamps / linked
CTPDB_P034101_ACT_baamps_0003	Antimicrobial	Anti-Biofilm	Not available in the current structured import	Unknown	Not reported by source	EXP00245baamps / linked
CTPDB_P034101_ACT_camp_0004	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ11926camp / linked
CTPDB_P034101_ACT_cancerppd_0005	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	3161cancerppd / linked
CTPDB_P034101_ACT_cancerppd_0006	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	3162cancerppd / linked
CTPDB_P034101_ACT_cancerppd_0007	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	3163cancerppd / linked
CTPDB_P034101_ACT_cancerppd_0008	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	3164cancerppd / linked
CTPDB_P034101_ACT_cppsite_0009	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	2008cppsite / linked
CTPDB_P034101_ACT_dbaasp_0010	Antimicrobial	-	9.6 µM	Escherichia coli D31	Not reported by source	DBAASPS_261_chain0dbaasp / linked
CTPDB_P034101_ACT_dbaasp_0011	Antimicrobial	-	5.1 µM	Staphylococcus aureus ATCC BAA-44	Not reported by source	DBAASPS_261_chain0dbaasp / linked
CTPDB_P034101_ACT_dbaasp_0012	Antimicrobial	-	8 µM	Fusarium solani	Not reported by source	DBAASPS_261_chain0dbaasp / linked
CTPDB_P034101_ACT_dbaasp_0013	Antimicrobial	-	16 µM	Fusarium oxysporum	Not reported by source	DBAASPS_261_chain0dbaasp / linked
CTPDB_P034101_ACT_dbaasp_0014	Antimicrobial	-	6.25 µM	Staphylococcus aureus USA 100	Not reported by source	DBAASPS_261_chain0dbaasp / linked
CTPDB_P034101_ACT_dbaasp_0015	Antimicrobial	-	12.5 µM	Staphylococcus aureus USA 300	Not reported by source	DBAASPS_261_chain0dbaasp / linked
CTPDB_P034101_ACT_dbaasp_0016	Antimicrobial	-	50 µM	Pseudomonas aeruginosa ATCC 9027	Not reported by source	DBAASPS_261_chain0dbaasp / linked
CTPDB_P034101_ACT_dbaasp_0017	Antimicrobial	-	>100 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_261_chain0dbaasp / linked
CTPDB_P034101_ACT_dbaasp_0018	Antimicrobial	-	>32 µg/ml	Candida albicans ATCC 90028	Not reported by source	DBAASPS_261_chain0dbaasp / linked
CTPDB_P034101_ACT_dbaasp_0019	Antimicrobial	-	>32 µg/ml	Cryptococcus neoformans ATCC 208821	Not reported by source	DBAASPS_261_chain0dbaasp / linked
CTPDB_P034101_ACT_dramp_0020	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03918dramp / linked
CTPDB_P034101_ACT_dramp_0021	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP03918dramp / linked
CTPDB_P034101_ACT_hemolytik_0022	Toxicity	Hemolytic	102.0 µM	Erythrocytes	Not reported by source	1080hemolytik / linked
CTPDB_P034101_ACT_satpdb_0023	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb16429satpdb / linked
CTPDB_P034101_ACT_satpdb_0024	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb19369satpdb / linked
CTPDB_P034101_ACT_satpdb_0025	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb19369satpdb / linked
CTPDB_P034101_ACT_satpdb_0026	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb19717satpdb / linked
CTPDB_P034101_ACT_satpdb_0027	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb19717satpdb / linked

Provenance

Source database records (16)

avpdb

AVPdb_AVP1532

Raw sequence

RWRWRWRW

baamps

EXP00235

Raw sequence

RWRWRWRW

baamps

EXP00236

Raw sequence

RWRWRWRW

baamps

EXP00245

Raw sequence

RWRWRWRW

camp

CAMPSQ11926

Raw sequence

RWRWRWRW

cancerppd

3161

Raw sequence

RWRWRWRW

cancerppd

3162

Raw sequence

RWRWRWRW

cancerppd

3163

Raw sequence

RWRWRWRW

cancerppd

3164

Raw sequence

RWRWRWRW

cppsite

2008

Raw sequence

RWRWRWRW

dbaasp

DBAASPS_261_chain0

Raw sequence

RWRWRWRW

dramp

DRAMP03918

Raw sequence

RWRWRWRW

hemolytik

1080

Raw sequence

RWRWRWRW

satpdb

satpdb16429

Raw sequence

RWRWRWRW

satpdb

satpdb19369

Raw sequence

RWRWRWRW

satpdb

satpdb19717

Raw sequence

RWRWRWRW

Citation trail

Literature (8 records)

Antiviral activity of selected antimicrobial peptides against vaccinia virus.

Mohan KV, Rao SS, Atreya CD.

Antiviral Res2010PMID 20347875

[{"title": "[Effects of Trp- and Arg-Containing Antimicrobial-Peptide Structure on Inhibition of Escherichia coli Planktonic Growth and Biofilm Formation](https://www.doi.org/10.1128/AEM.02321-09)", "authors": "S. Hou, Z. Liu, A. W. Young, S. L. Mark, N. R. Kallenbach, D. Ren", "publication": "2010.Applied and Environmental Microbiology 6:1967-1974"}]

[{"title": "[Effects of Trp- and Arg-Containing Antimicrobial-Peptide Structure on Inhibition of Escherichia coli Planktonic Growth and Biofilm Formation](https://www.doi.org/10.1128/AEM.02321-09)", "authors": "S. Hou, Z. Liu, A. W. Young, S. L. Mark, N. R. Kallenbach, D. Ren", "publication": "2010.Applied and Environmental Microbiology 6:1967-1974"}]

[{"title": "[Control of Bacterial Persister Cells by Trp/Arg-Containing Antimicrobial Peptides](https://www.doi.org/10.1128/AEM.02440-10)", "authors": "X. Chen, M. Zhang, C. Zhou, N. R. Kallenbach, D. Ren", "publication": "2011.Applied and Environmental Microbiology 14:4878-4885"}]

[{"title": "[Control of Bacterial Persister Cells by Trp/Arg-Containing Antimicrobial Peptides](https://www.doi.org/10.1128/AEM.02440-10)", "authors": "X. Chen, M. Zhang, C. Zhou, N. R. Kallenbach, D. Ren", "publication": "2011.Applied and Environmental Microbiology 14:4878-4885"}]

-

--PMID 28105725

-

--PMID 23301519

Length effects in antimicrobial peptides of the (RW)n series

Liu Z, Brady A, Young A, Rasimick B, Chen K, Zhou C, Kallenbach NR

Antimicrob Agents Chemother2007PMID 17145799

Length effects in antimicrobial peptides of the (RW)n series

Liu Z, Brady A, Young A, Rasimick B, Chen K, Zhou C, Kallenbach NR

Antimicrob Agents Chemother2007PMID 23203110

Length effects in antimicrobial peptides of the (RW)n series

Liu Z, Brady A, Young A, Rasimick B, Chen K, Zhou C, Kallenbach NR

Antimicrob Agents Chemother2007PMID 39583727

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:13.352051+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Sheep erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human embryonic kidney HEK293 cells"
    },
    {
      "source_db": "dbaasp",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "avpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "baamps",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cppsite",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCCSCC"
}