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PEPDIA-INT-033973

Silver

Pentapeptide PAST18

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

TLSAC

Indexed sequence5 aa

1TLSAC

Length

Molecular weight

493.58 Da

Formula

C19H35N5O8S

Structure type

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar3

Solubility proxy

Charged0

Net charge proxy +0

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

493.5749 Da

Molecular formula

C19H35N5O8S

Theoretical pI

5.1835

Net charge at pH 7

-0.6117

GRAVY

1.32

Instability index

95.88

Aromaticity

Topological polar surface area

220.18 Å²

cLogP

-3.2936

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

TLSAC

HELM 2.0

validated simple linear

PEPTIDE1{T.L.S.A.C}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(N)C(C)O)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CS)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-033973,
  title = {Pentapeptide PAST18},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-033973},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Pentapeptide PAST18. (2026). PepDiana record PEPDIA-INT-033973. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-033973

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (21 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P033973_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP03625apd / linked
CTPDB_P033973_ACT_apd_0001	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP03625apd / linked
CTPDB_P033973_ACT_apd_0003	Antimicrobial	Anti-Biofilm	Not available in the current structured import	Unknown	Not reported by source	AP03625apd / linked
CTPDB_P033973_ACT_dbaasp_0004	Antimicrobial	-	25 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0005	Antimicrobial	-	35 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0006	Antimicrobial	-	30 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0007	Antimicrobial	-	40 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0008	Antimicrobial	-	40 µM	Enterococcus faecalis ATCC 29212	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0009	Antimicrobial	-	47.5 µM	Enterococcus faecalis ATCC 29212	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0010	Antimicrobial	-	30 µM	Klebsiella pneumoniae ATCC BAA-1705	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0011	Antimicrobial	-	35 µM	Klebsiella pneumoniae ATCC BAA-1705	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0012	Antimicrobial	-	25 µM	Acinetobacter baumannii ATCC BAA-1605	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0013	Antimicrobial	-	35 µM	Acinetobacter baumannii ATCC BAA-1605	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0014	Antimicrobial	-	30 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0015	Antimicrobial	-	40 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0016	Antimicrobial	-	50 µM	Candida albicans	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0017	Antimicrobial	-	75 µM	Candida albicans	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0018	Antimicrobial	-	20 µM	Alternaria solani	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0019	Antimicrobial	-	35 µM	Alternaria solani	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0020	Antimicrobial	-	30 µM	Ustilago maydis	Not reported by source	DBAASPS_21035_chain0dbaasp / linked
CTPDB_P033973_ACT_dbaasp_0021	Antimicrobial	-	50 µM	Ustilago maydis	Not reported by source	DBAASPS_21035_chain0dbaasp / linked

Provenance

Source database records (2)

apd

AP03625

Raw sequence

TLSAC

dbaasp

DBAASPS_21035_chain0

Raw sequence

TLSAC

Citation trail

Literature (1 records)

Characterization of an antimicrobial pentapeptide produced by a drug-sensitive Pseudomonas aeruginosa strain PAST18

Deb S, Dutta TK. 2023

Biochem Biophys Res Commun2023PMID 37119769

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.802554+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "25",
      "source_db": "dbaasp",
      "assay_method": "23.5% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human embryonic kidney HEK293 cells"
    },
    {
      "unit": "µM",
      "value": "40",
      "source_db": "dbaasp",
      "assay_method": "29% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human embryonic kidney HEK293 cells"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  }
]