ProForma 2.0
validated simple linear
DIGYY
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PEPDIA-INT-032525
GoldPepDiana tier derived from the internal quality score plus activity and literature coverage; it is not an external database rating.Angiotensin I-converting enzyme inhibitor 12
85
Quality PepDiana 0–100 composite of sequence, source, activity, literature, and cross-database evidence completeness.
3
Source DBs
3
Activities
3
Source refs
3
Literature
0
Patents
Integrated record
Sequence and molecular profile
DIGYY
Indexed sequence5 aa
1DIGYY
Length
5
Molecular weight
629.67 Da
Formula
C30H39N5O10
Structure type
Linear
Synthesis
-
Chirality
-
Family
-
Gene
-
Residue composition
Y
2
D
1
I
1
G
1
Physicochemical profile
Hydrophobic3
Membrane affinity proxy
Polar0
Solubility proxy
Charged1
Net charge proxy -1
Aromatic2
Binding interaction proxy
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.
Computed properties
physchem-20260620Molecular weight
629.658 Da
Molecular formula
C30H39N5O10
Theoretical pI
4.05
Net charge at pH 7
-1.2408
GRAVY
-0.4
Instability index
15.7
Aromaticity
0.4
Topological polar surface area
257.48 Ų
cLogP
-0.6137
Hydrogen-bond donors
9
Hydrogen-bond acceptors
9
Rotatable bonds
17
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{D.I.G.Y.Y}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)C(N)CC(=O)O)C(=O)NCC(=O)NC(Cc1ccc(O)cc1)C(=O)NC(Cc1ccc(O)cc1)C(=O)O
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Follow-up research
External analysis tools
Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.
Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.
Research workflow
Citation and local history
BibTeX
@misc{PEPDIA-INT-032525,
title = {Angiotensin I-converting enzyme inhibitor 12},
author = {{PepDiana Consortium}},
year = {2026},
howpublished = {PepDiana Multifunctional Peptide Database},
url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-032525},
note = {Accessed from local PepDiana development build}
}APA-style note
Angiotensin I-converting enzyme inhibitor 12. (2026). PepDiana record PEPDIA-INT-032525. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-032525
This record is saved to local recent-view history so it can reappear on the peptide browser page.
Integrated source-database annotations
Biological activity (3 records)
| Stable record | Activity | Subtype | Value | Target | Assay method | Source |
|---|---|---|---|---|---|---|
| CTPDB_P032525_ACT_ahtpdb_0000 | Metabolic/Cardiovascular | ACE Inhibitor | 3.39 µM | Unknown | Not reported by source | 2325ahtpdb / linked |
| CTPDB_P032525_ACT_plantpepdb_0001 | Enzyme Inhibitor | General Enzyme Inhibitor | Not available in the current structured import | Unknown | Not reported by source | PPepDB_3029plantpepdb / linked |
| CTPDB_P032525_ACT_satpdb_0002 | Metabolic/Cardiovascular | Antihypertensive | Not available for this observation | Unknown | Not reported by source | satpdb21790satpdb / linked |
Provenance
Source database records (3)
Citation trail
Literature (3 records)
A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.
Sagardia I1, Roa-Ureta RH, Bald C.
-
-
-
-
Audit surface
Raw annotations and release metadata
Integrated record last updated: 2026-04-15T00:59:11.113046+00:00
Modification summary
No structured modification annotations are available for this record.
Source metadata
[
{
"source_db": "ahtpdb",
"organism_name": "Unknown"
},
{
"source_db": "plantpepdb",
"organism_name": "Unknown"
},
{
"source_db": "satpdb",
"organism_name": "Unknown"
}
]Structure metadata
{
"source_db": "satpdb",
"dssp_states": "CCSCC"
}