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PEPDIA-INT-032481

Gold

Hemolytic Peptide A1

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

FLPAIAGILSQLF

Indexed sequence13 aa

1FLPAIAGILSQLF

Length

Molecular weight

1389.70 Da

Formula

C69H108N14O16

Structure type

Linear

Synthesis

Ribosomal

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic9

Membrane affinity proxy

Polar2

Solubility proxy

Charged0

Net charge proxy +0

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1389.6797 Da

Molecular formula

C69H108N14O16

Theoretical pI

5.525

Net charge at pH 7

-0.2399

GRAVY

1.7923

Instability index

61.9615

Aromaticity

0.1538

Topological polar surface area

467.05 Å²

cLogP

-0.633

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

FLPAIAGILSQLF

HELM 2.0

validated simple linear

PEPTIDE1{F.L.P.A.I.A.G.I.L.S.Q.L.F}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)CNC(=O)C(C)NC(=O)C(NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CC(C)C)NC(=O)C(N)Cc1ccccc1)C(C)CC)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-032481,
  title = {Hemolytic Peptide A1},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-032481},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Hemolytic Peptide A1. (2026). PepDiana record PEPDIA-INT-032481. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-032481

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (9 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P032481_ACT_apd_0000	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	AP00664apd / linked
CTPDB_P032481_ACT_camp_0001	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ2833camp / linked
CTPDB_P032481_ACT_dbaasp_0002	Antimicrobial	-	>200 µM	Staphylococcus aureus NCTC 10788	Not reported by source	DBAASPS_10909_chain0dbaasp / linked
CTPDB_P032481_ACT_dbaasp_0003	Antimicrobial	-	>50 µM	Escherichia coli NCTC 10418	Not reported by source	DBAASPS_10909_chain0dbaasp / linked
CTPDB_P032481_ACT_dramp_0004	Unknown	Unknown	Not available in the current structured import	Unknown	Not reported by source	DRAMP02153dramp / linked
CTPDB_P032481_ACT_hemolytik_0005	Toxicity	Hemolytic	20.0 µM	Erythrocytes	Not reported by source	3686hemolytik / linked
CTPDB_P032481_ACT_satpdb_0006	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb10431satpdb / linked
CTPDB_P032481_ACT_satpdb_0007	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb10431satpdb / linked
CTPDB_P032481_ACT_satpdb_0008	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb15300satpdb / linked

Provenance

Source database records (7)

apd

AP00664

Raw sequence

FLPAIAGILSQLF

camp

CAMPSQ2833

Raw sequence

FLPAIAGILSQLF

dbaasp

DBAASPS_10909_chain0

Raw sequence

FLPAIAGILSQLF

dramp

DRAMP02153

Raw sequence

FLPAIAGILSQLF

hemolytik

3686

Raw sequence

FLPAIAGILSQLF

satpdb

satpdb10431

Raw sequence

FLPAIAGILSQLF

satpdb

satpdb15300

Raw sequence

FLPAIAGILSQLF

Citation trail

Literature (4 records)

{"reference": "Biochim Biophys Acta 1990; 1033: 318-323", "title": "Purification and characterization of bioactive peptides from skin extracts of Rana esculenta", "author": "Simmaco M et al Bossa F1990"}

{"reference": "Biochim Biophys Acta 1990; 1033: 318-323", "title": "Purification and characterization of bioactive peptides from skin extracts of Rana esculenta", "author": "Simmaco M et al Bossa F1990"}

-

--PMID 2317508

Purification and characterization of bioactive peptides from skin extracts of Rana esculenta.

Simmaco M, De Biase D, Severini C, Aita M, Erspamer GF, Barra D, Bossa F

Biochim Biophys Acta1990PMID 29191658

-

--PMID 8508915

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.203743+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "1.5",
      "source_db": "dbaasp",
      "assay_method": "20% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "3",
      "source_db": "dbaasp",
      "assay_method": "70% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.11738090]5% hemolytic activity at 1 nmol/ml, 20% hemolytic activity at 1.5nmol/ml, 30% hemolytic activity at 2nmol/ml, 60% hemolytic activity at 2.5nmol/ml, 88% hemolytic activity at 3nmol/ml, 95% hemolytic activity at 3.5nmol/ml against human erythrocytes",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCTTSGGGTTTCC"
}