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PEPDIA-INT-032402

Gold

Neutrophil defensin 2, HNP-2

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

CYCRIPACIAGERRYGTCIYQGRLWAFCC

Indexed sequence29 aa

1CYCRIPACIAGERRYGTCIYQGRLWAFCC

Length

Molecular weight

Formula

Structure type

Cyclic

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic12

Membrane affinity proxy

Polar8

Solubility proxy

Charged5

Net charge proxy +3

Aromatic5

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

partial sequence only structural context

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

3376.9991 Da

Molecular formula

Not calculated

Theoretical pI

8.6745

Net charge at pH 7

2.7005

GRAVY

0.2483

Instability index

42.1345

Aromaticity

0.1724

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

not generated modification context

Not calculated for this record

HELM 2.0

not generated modification context

Not calculated for this record

Canonical SMILES

not generated modification context

Not calculated for this record

Isomeric SMILES

not generated modification context

Not calculated for this record

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-032402,
  title = {Neutrophil defensin 2, HNP-2},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-032402},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Neutrophil defensin 2, HNP-2. (2026). PepDiana record PEPDIA-INT-032402. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-032402

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (45 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P032402_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP00177apd / linked
CTPDB_P032402_ACT_apd_0001	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	AP00177apd / linked
CTPDB_P032402_ACT_apd_0002	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP00177apd / linked
CTPDB_P032402_ACT_apd_0003	Antiviral	Anti-HIV	Not available in the current structured import	Unknown	Not reported by source	AP00177apd / linked
CTPDB_P032402_ACT_apd_0004	Bioregulatory	Chemotactic	Not available in the current structured import	Unknown	Not reported by source	AP00177apd / linked
CTPDB_P032402_ACT_apd_0005	Neuroactive/Ion Channel	Toxin	Not available in the current structured import	Unknown	Not reported by source	AP00177apd / linked
CTPDB_P032402_ACT_apd_0006	Enzyme Inhibitor	General Enzyme Inhibitor	Not available in the current structured import	Unknown	Not reported by source	AP00177apd / linked
CTPDB_P032402_ACT_apd_0007	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	AP00177apd / linked
CTPDB_P032402_ACT_camp_0008	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ2738camp / linked
CTPDB_P032402_ACT_camp_0009	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ2738camp / linked
CTPDB_P032402_ACT_cancerppd_0010	Anticancer	Anticancer	Not available in the current structured import	Unknown	Not Available	4431cancerppd / linked
CTPDB_P032402_ACT_dbaasp_0011	Antimicrobial	-	5-20 µM	HIV-1 IIIB	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0012	Antimicrobial	-	5-20 µM	HIV-1 BaL	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0013	Antimicrobial	-	5-20 µM	HIV-1 B703	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0014	Antimicrobial	-	5-20 µM	HIV-1 NSI03	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0015	Antimicrobial	-	1 µg/ml	Escherichia coli CIP 76.24	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0016	Antimicrobial	-	2 µg/ml	Escherichia coli CIP 76.24	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0017	Antimicrobial	-	0.5 µg/ml	Escherichia coli	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0018	Antimicrobial	-	0.5 µg/ml	Escherichia coli	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0019	Antimicrobial	-	1 µg/ml	Pseudomonas aeruginosa CIP 76.110	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0020	Antimicrobial	-	4 µg/ml	Pseudomonas aeruginosa CIP 76.110	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0021	Antimicrobial	-	>4 µg/ml	Acinetobacter baumannii CIP 70.34T	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0022	Antimicrobial	-	1 µg/ml	Acinetobacter baumannii	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0023	Antimicrobial	-	4 µg/ml	Acinetobacter baumannii	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0024	Antimicrobial	-	0.5 µg/ml	Yersinia enterocolitica CIP 80.27T	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0025	Antimicrobial	-	4 µg/ml	Yersinia enterocolitica CIP 80.27T	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0026	Antimicrobial	-	0.5 µg/ml	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0027	Antimicrobial	-	1 µg/ml	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0028	Antimicrobial	-	0.5 µg/ml	Staphylococcus epidermidis CIP 68.21	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dbaasp_0029	Antimicrobial	-	1 µg/ml	Staphylococcus epidermidis CIP 68.21	Not reported by source	DBAASPS_5401_chain0dbaasp / linked
CTPDB_P032402_ACT_dramp_0030	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03592dramp / linked
CTPDB_P032402_ACT_dramp_0031	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP03592dramp / linked
CTPDB_P032402_ACT_dramp_0032	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP03592dramp / linked
CTPDB_P032402_ACT_dramp_0033	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03592dramp / linked
CTPDB_P032402_ACT_dramp_0034	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP03592dramp / linked
CTPDB_P032402_ACT_dramp_0035	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03592dramp / linked
CTPDB_P032402_ACT_dramp_0036	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP04818dramp / linked
CTPDB_P032402_ACT_dramp_0037	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP18901dramp / linked
CTPDB_P032402_ACT_hemolytik_0038	Toxicity	Hemolytic	80.0 µg/ml	Erythrocytes	Not reported by source	2433hemolytik / linked
CTPDB_P032402_ACT_satpdb_0039	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb11499satpdb / linked
CTPDB_P032402_ACT_satpdb_0040	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb11499satpdb / linked
CTPDB_P032402_ACT_satpdb_0041	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb11499satpdb / linked
CTPDB_P032402_ACT_satpdb_0042	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb11499satpdb / linked
CTPDB_P032402_ACT_satpdb_0043	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb11499satpdb / linked
CTPDB_P032402_ACT_satpdb_0044	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb11499satpdb / linked

Provenance

Source database records (10)

apd

AP00177

Raw sequence

CYCRIPACIAGERRYGTCIYQGRLWAFCC

camp

CAMPSQ2738

Raw sequence

CYCRIPACIAGERRYGTCIYQGRLWAFCC

cancerppd

4431

Raw sequence

CYCRIPACIAGERRYGTCIYQGRLWAFCC

dbaasp

DBAASPS_5401_chain0

Raw sequence

CYCRIPACIAGERRYGTCIYQGRLWAFCC

dramp

DRAMP03592

Raw sequence

CYCRIPACIAGERRYGTCIYQGRLWAFCC

dramp

DRAMP04818

Raw sequence

CYCRIPACIAGERRYGTCIYQGRLWAFCC

dramp

DRAMP18901

Raw sequence

CYCRIPACIAGERRYGTCIYQGRLWAFCC

hemolytik

2433

Raw sequence

CYCRIPACIAGERRYGTCIYQGRLWAFCC

kalium

1697

Raw sequence

CYCRIPACIAGERRYGTCIYQGRLWAFCC

satpdb

satpdb11499

Raw sequence

CYCRIPACIAGERRYGTCIYQGRLWAFCC

Citation trail

Literature (7 records)

Primary structures of three human neutrophil defensins

Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI1985

J Clin Invest1985PMID 4056036

-

--PMID 15616305

Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides.

Yasin B, Pang M, Turner JS, Cho Y, Dinh NN, Waring AJ, Lehrer RI, Wagar EA

Eur J Clin Microbiol Infect Dis2000PMID 10795591

Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides.

Yasin B, Pang M, Turner JS, Cho Y, Dinh NN, Waring AJ, Lehrer RI, Wagar EA

Eur J Clin Microbiol Infect Dis2000PMID 15620707

Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides.

Yasin B, Pang M, Turner JS, Cho Y, Dinh NN, Waring AJ, Lehrer RI, Wagar EA

Eur J Clin Microbiol Infect Dis2000PMID 24117506

Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Antibacterial activity and specificity of the six human {alpha}-defensins.##Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.

Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Ericksen B, Wu Z, Lu W, Lehrer RI.##Xie C, Prahl A, Ericksen B, Wu Z, Zeng P, Li X, Lu WY, Lubkowski J, Lu W.

Viruses2021PMID 34206990

Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Antibacterial activity and specificity of the six human {alpha}-defensins.##Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.

Viruses2021PMID 15894545

IP evidence

Patents (2)

US 20030092612

dramp

US 6872705

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.941613+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "80",
      "source_db": "dbaasp",
      "assay_method": "1% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "kalium",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "pdb_id": [
    "1ZMH, 1ZMI, 1ZMK resolved by X-ray.",
    "[2KHT,2PM1,3GNY,3H6C,3HJ2,3HJD,3LO1,3LO2,3LO4,3LO6,3LO9,3LOE,3LVX,4DU0,4LB1,4LB7,4LBB,4LBF](http://www.rcsb.org/pdb/explore/explore.do?structureId=2KHT,2PM1,3GNY,3H6C,3HJ2,3HJD,3LO1,3LO2,3LO4,3LO6,3LO9,3LOE,3LVX,4DU0,4LB1,4LB7,4LBB,4LBF)"
  ],
  "source_db": "dramp"
}