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PEPDIA-INT-031652

Gold

Diketopiperazine (GV)

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

Indexed sequence2 aa

1GV

Length

Molecular weight

Formula

Structure type

Cyclic

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar0

Solubility proxy

Charged0

Net charge proxy +0

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

partial sequence only structural context

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

174.1976 Da

Molecular formula

Not calculated

Theoretical pI

5.525

Net charge at pH 7

-0.2399

GRAVY

1.9

Instability index

Aromaticity

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

not generated modification context

Not calculated for this record

HELM 2.0

not generated modification context

Not calculated for this record

Canonical SMILES

not generated modification context

Not calculated for this record

Isomeric SMILES

not generated modification context

Not calculated for this record

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-031652,
  title = {Diketopiperazine (GV)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-031652},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Diketopiperazine (GV). (2026). PepDiana record PEPDIA-INT-031652. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-031652

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (33 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P031652_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	20.0 mM	Unknown	Not reported by source	1429ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0004	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	1689ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0005	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3021ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0006	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3026ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0007	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3098ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0008	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3119ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0009	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3140ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0010	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3160ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0011	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3241ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0012	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3333ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0013	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3423ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0014	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3811ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0015	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3837ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0016	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3936ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4412ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4517ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4680ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0017	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	5435ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0018	Metabolic/Cardiovascular	ACE Inhibitor	17.0 µM	Unknown	Cushman and Cheung (1971)	6170ahtpdb / linked
CTPDB_P031652_ACT_ahtpdb_0019	Metabolic/Cardiovascular	ACE Inhibitor	4600.0 µM	Unknown	Not reported by source	6594ahtpdb / linked
CTPDB_P031652_ACT_dramp_0020	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP33820dramp / linked
CTPDB_P031652_ACT_dramp_0021	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP33820dramp / linked
CTPDB_P031652_ACT_dramp_0022	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP33821dramp / linked
CTPDB_P031652_ACT_dramp_0023	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP33821dramp / linked
CTPDB_P031652_ACT_parapep_0024	Antiparasitic	Antiparasitic	3.16 µM	Unknown	Microscopy	1160parapep / linked
CTPDB_P031652_ACT_plantpepdb_0025	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	PPepDB_71plantpepdb / linked
CTPDB_P031652_ACT_satpdb_0026	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb23204satpdb / linked
CTPDB_P031652_ACT_satpdb_0027	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb23204satpdb / linked
CTPDB_P031652_ACT_satpdb_0028	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb23204satpdb / linked
CTPDB_P031652_ACT_satpdb_0029	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb23204satpdb / linked
CTPDB_P031652_ACT_satpdb_0030	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb23204satpdb / linked
CTPDB_P031652_ACT_satpdb_0031	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb23204satpdb / linked
CTPDB_P031652_ACT_satpdb_0032	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb25124satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003631 View all experimental records

Provenance

Source database records (26)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

ahtpdb

4412

Raw sequence

ahtpdb

4517

Raw sequence

ahtpdb

4680

Raw sequence

ahtpdb

1429

Raw sequence

ahtpdb

1689

Raw sequence

ahtpdb

6170

Raw sequence

ahtpdb

6594

Raw sequence

ahtpdb

5435

Raw sequence

ahtpdb

3021

Raw sequence

ahtpdb

3026

Raw sequence

ahtpdb

3098

Raw sequence

ahtpdb

3119

Raw sequence

ahtpdb

3140

Raw sequence

ahtpdb

3160

Raw sequence

ahtpdb

3241

Raw sequence

ahtpdb

3333

Raw sequence

ahtpdb

3423

Raw sequence

ahtpdb

3811

Raw sequence

ahtpdb

3837

Raw sequence

ahtpdb

3936

Raw sequence

dramp

DRAMP33820

Raw sequence

dramp

DRAMP33821

Raw sequence

parapep

1160

Raw sequence

plantpepdb

PPepDB_71

Raw sequence

satpdb

satpdb23204

Raw sequence

satpdb

satpdb25124

Raw sequence

Citation trail

Literature (14 records)

Modelling relationship between angiotensin-(I)-converting enzyme inhibition and the bitter taste of peptides

Are Hugo Pripp, Ylva Ardö

Food Chemistry - FOOD CHEM 01/2007; 102(3):880-888.2007

QSAR study on angiotensin-converting enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors.

Wang X1, Wang J, Lin Y, Ding Y, Wang Y, Cheng X, Lin Z.

J Mol Model. 2011 Jul;17(7):1599-606.2011PMID 20941517

What are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach.

Zhou P et al.

Food Chem. 2013 Dec 1;141(3):2967-73.2013PMID 23871047

Structural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides.

Wu J1, Aluko RE, Nakai S.

J Agric Food Chem. 2006 Feb 8;54(3):732-8.2006PMID 16448176

BIOPEP-PBIL Tool for the Analysis of the Structure of Biologically Active Motifs Derived from Food Proteins

Anna Iwaniak* and Jerzy Dziuba

Analysis of Biologically Active Motifs, Food Technol. Biotechnol. 49 (1) 118–127 (2011)2011

Angiotensin I-converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish sauce

Ichimura, T. et al.

J Biosci Bioeng 96 p.496-92003PMID 16233562

Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.

Cheung HS et al.,

J Biol Chem. 1980 Jan 25;255(2):401-7.1980PMID 6243277

Quantitative structure-activity relationship study of bitter di- and tri-peptides including relationship with angiotensin I-converting enzyme inhibitory activity.

Wu J1, Aluko RE.

J Pept Sci. 2007 Jan;13(1):63-9.2007PMID 17117396

Peptides with angiotensin I converting enzyme (ACE) inhibitory activity generated from porcine skeletal muscle proteins by the action of meat-borne Lactobacillus.

Castellano P1, Aristoy MC, Sentandreu MÁ, Vignolo G, Toldrá F.

J Proteomics. 2013 Aug 26;89:183-90.2013PMID 23806758

Animal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation

Anna Iwaniak and Jerzy Dziuba

Food Technol. Biotechnol. 47 (4) 441–449 (2009)2009

Three-dimensional holograph vector of atomic interaction field (3D-HoVAIF): a novel rotation-translation invariant 3D structure descriptor and its applications to peptides.

Tian F1, Zhou P, Lv F, Song R, Li Z.

J Pept Sci. 2007 Aug;13(8):549-66.2007PMID 17654623

Identification of Bioactive Peptides from Cereal Storage Proteins and Their Potential Role in Prevention of Chronic Diseases

Ariel Cavazos and Elvira Gonzalez de Mejia

Comprehensive Reviews in Food Science and Food Safety Volume 12, Issue 4, pages 364–380, July 20132013

The synthesis and anticancer activity of selected diketopiperazines

van der Merwe E, Huang D, Peterson D, Kilian G, Milne PJ, Van de Venter M, Frost C.

Peptides2008PMID 18436344

-

--PMID 23084276

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CC"
}