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PEPDIA-INT-027570

Gold

Gaegurin 5 (1-11)[A4W][V8W][S10W]

85

Quality

7

Source DBs

87

Activities

37

Source refs

3

Literature

1

Patents

Integrated record

Sequence and molecular profile

FLGWLFKWAWK
Indexed sequence11 aa
1FLGWLFKWAWK

Length

11

Molecular weight

1481.81 Da

Formula

C80H104N16O12

Structure type

Linear

Synthesis

Synthetic

Chirality

L

Family

-

Gene

-

Residue composition

W
3
F
2
L
2
K
2
G
1
A
1

Physicochemical profile

Hydrophobic8

Membrane affinity proxy

Polar0

Solubility proxy

Charged2

Net charge proxy +2

Aromatic5

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1481.7816 Da

Molecular formula

C80H104N16O12

Theoretical pI

10.0027

Net charge at pH 7

1.7581

GRAVY

0.3727

Instability index

4.2

Aromaticity

0.4545

Topological polar surface area

453.73 Ų

cLogP

3.9052

Hydrogen-bond donors

17

Hydrogen-bond acceptors

14

Rotatable bonds

43

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

FLGWLFKWAWK

HELM 2.0

validated simple linear

PEPTIDE1{F.L.G.W.L.F.K.W.A.W.K}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(N)Cc1ccccc1)C(=O)NCC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-027570,
  title = {Gaegurin 5 (1-11)[A4W][V8W][S10W]},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-027570},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Gaegurin 5 (1-11)[A4W][V8W][S10W]. (2026). PepDiana record PEPDIA-INT-027570. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-027570

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (87 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P027570_ACT_apd_0000AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceAP05678apd / linked
CTPDB_P027570_ACT_camp_0001AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ13775camp / linked
CTPDB_P027570_ACT_camp_0002AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ13775camp / linked
CTPDB_P027570_ACT_cancerppd_0031AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1722cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0032Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1722cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0033AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1723cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0034Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1723cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0035AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1724cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0036Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1724cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0037AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1725cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0038Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1725cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0039AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1726cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0040Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1726cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0041AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1727cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0042Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1727cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0043AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1736cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0044Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1736cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0045AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1740cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0046Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1740cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0047AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1757cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0048Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1757cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0049AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1758cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0050Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1758cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0051AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1759cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0052Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1759cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0053AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1760cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0054Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1760cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0055AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1761cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0056Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1761cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0057AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1762cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0058Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1762cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0059AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1763cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0060Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1763cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0061AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1764cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0062Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1764cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0003AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3226cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0004Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3226cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0005AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3227cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0006Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3227cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0007AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3228cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0008Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3228cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0009AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3229cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0010Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3229cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0011AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3230cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0012Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3230cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0013AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3231cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0014Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3231cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0015AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3232cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0016Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3232cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0017AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3727cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0018Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3727cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0019AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3728cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0020Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3728cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0021AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3729cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0022Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3729cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0023AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3730cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0024Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3730cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0025AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3731cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0026Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3731cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0027AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3732cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0028Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3732cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0029AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3733cancerppd / linked
CTPDB_P027570_ACT_cancerppd_0030Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3733cancerppd / linked
CTPDB_P027570_ACT_dbaasp_0063Antimicrobial-6.3 µg/mlBacillus subtilis ATCC 6633Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0064Antimicrobial-3.1 µg/mlMicrococcus luteus ATCC 10240Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0065Antimicrobial-6.3 µg/mlStaphylococcus aureus ATCC 6538PNot reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0066Antimicrobial-6.3 µg/mlStaphylococcus epidermidis ATCC 12228Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0067Antimicrobial-25 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0068Antimicrobial-12.5 µg/mlShigella dysenteriae ATCC 9752Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0069Antimicrobial-100 µg/mlSalmonella enterica subsp. enterica serovar Typhimurium ATCC 14028Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0070Antimicrobial-12.5 µg/mlKlebsiella pneumoniae ATCC 10031Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0071Antimicrobial->200 µg/mlPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0072Antimicrobial-22.88 µMHuman renal carcinoma A498Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0073Antimicrobial-20.36 µMHuman lung carcinoma A549Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0074Antimicrobial-24.63 µMHuman colon adenocarcinoma HCT 116Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0075Antimicrobial-24.31 µMHuman gastric cancer MKN 45Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0076Antimicrobial-46.51 µMHuman prostate adenocarcinoma PC-3Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0077Antimicrobial-13.97 µMHuman skin melanoma SK-MEL-2Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dbaasp_0078Antimicrobial-22.06 µMHuman ovarian adenocarcinoma SK-OV-3Not reported by sourceDBAASPS_928_chain0dbaasp / linked
CTPDB_P027570_ACT_dramp_0079Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP09410dramp / linked
CTPDB_P027570_ACT_dramp_0080Anticancer-Not available in the current structured importUnknownNot reported by sourceDRAMP09410dramp / linked
CTPDB_P027570_ACT_hemolytik_0081ToxicityHemolytic50.0 µg/mlErythrocytesNot reported by source1554hemolytik / linked
CTPDB_P027570_ACT_satpdb_0082Anticancer-Not available in the current structured importUnknownNot reported by sourcesatpdb23294satpdb / linked
CTPDB_P027570_ACT_satpdb_0083ToxicityGeneral ToxicNot available in the current structured importUnknownNot reported by sourcesatpdb23294satpdb / linked
CTPDB_P027570_ACT_satpdb_0084Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb23294satpdb / linked
CTPDB_P027570_ACT_satpdb_0085Anticancer-Not available in the current structured importUnknownNot reported by sourcesatpdb25929satpdb / linked
CTPDB_P027570_ACT_satpdb_0086Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb25929satpdb / linked

Provenance

Source database records (37)

apd

AP05678

Raw sequence

FLGWLFKWAWK

camp

CAMPSQ13775

Raw sequence

FLGWLFKWAWK

cancerppd

3226

Raw sequence

FLGWLFKWAWK

cancerppd

3227

Raw sequence

FLGWLFKWAWK

cancerppd

3228

Raw sequence

FLGWLFKWAWK

cancerppd

3229

Raw sequence

FLGWLFKWAWK

cancerppd

3230

Raw sequence

FLGWLFKWAWK

cancerppd

3231

Raw sequence

FLGWLFKWAWK

cancerppd

3232

Raw sequence

FLGWLFKWAWK

cancerppd

3727

Raw sequence

FLGWLFKWAWK

cancerppd

3728

Raw sequence

FLGWLFKWAWK

cancerppd

3729

Raw sequence

FLGWLFKWAWK

cancerppd

3730

Raw sequence

FLGWLFKWAWK

cancerppd

3731

Raw sequence

FLGWLFKWAWK

cancerppd

3732

Raw sequence

FLGWLFKWAWK

cancerppd

3733

Raw sequence

FLGWLFKWAWK

cancerppd

1722

Raw sequence

FLGWLFKWAWK

cancerppd

1723

Raw sequence

FLGWLFKWAWK

cancerppd

1724

Raw sequence

FLGWLFKWAWK

cancerppd

1725

Raw sequence

FLGWLFKWAWK

cancerppd

1726

Raw sequence

FLGWLFKWAWK

cancerppd

1727

Raw sequence

FLGWLFKWAWK

cancerppd

1736

Raw sequence

FLGWLFKWAWK

cancerppd

1740

Raw sequence

FLGWLFKWAWK

cancerppd

1757

Raw sequence

FLGWLFKWAWK

cancerppd

1758

Raw sequence

FLGWLFKWAWK

cancerppd

1759

Raw sequence

FLGWLFKWAWK

cancerppd

1760

Raw sequence

FLGWLFKWAWK

cancerppd

1761

Raw sequence

FLGWLFKWAWK

cancerppd

1762

Raw sequence

FLGWLFKWAWK

cancerppd

1763

Raw sequence

FLGWLFKWAWK

cancerppd

1764

Raw sequence

FLGWLFKWAWK

dbaasp

DBAASPS_928_chain0

Raw sequence

FLGWLFKWAWK

dramp

DRAMP09410

Raw sequence

FLGWLFKWAWK

hemolytik

1554

Raw sequence

FLGWLFKWAWK

satpdb

satpdb23294

Raw sequence

FLGWLFKWAWK

satpdb

satpdb25929

Raw sequence

FLGWLFKWAWK

Citation trail

Literature (3 records)

Activity optimization of an undecapeptide analogue derived from a frog-skin antimicrobial peptide.

Won HS, Kang SJ, Choi WS, Lee BJ. 2011

Mol Cells2011PMID 21110126

{"pubmed_id": "[None](http://www.ncbi.nlm.nih.gov/pubmed/None)", "year": "2011"}

-

--

IP evidence

Patents (1)

US 8076284

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.385336+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "50",
      "source_db": "dbaasp",
      "assay_method": "5% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}
Source metadata
[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "source_db": "satpdb",
  "dssp_states": "CCSSSSCCCCC"
}