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PEPDIA-INT-027148

Silver

Cyclo(Trp-Arg), Diketopiperazine (WR)

65

Quality

2

Source DBs

64

Activities

6

Source refs

4

Literature

0

Patents

Integrated record

Sequence and molecular profile

WR
Indexed sequence2 aa
1WR

Length

2

Molecular weight

360.42 Da

Formula

C17H24N6O3

Structure type

-

Synthesis

Synthetic

Chirality

-

Family

-

Gene

-

Residue composition

W
1
R
1

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy +1

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

360.4109 Da

Molecular formula

C17H24N6O3

Theoretical pI

9.75

Net charge at pH 7

0.7601

GRAVY

-2.7

Instability index

5

Aromaticity

0.5

Topological polar surface area

170.11 Ų

cLogP

-0.1296

Hydrogen-bond donors

7

Hydrogen-bond acceptors

4

Rotatable bonds

9

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

WR

HELM 2.0

validated simple linear

PEPTIDE1{W.R}$$$$V2.0

Canonical SMILES

validated

N=C(N)NCCCC(NC(=O)C(N)Cc1c[nH]c2ccccc12)C(=O)O

Isomeric SMILES

validated

N=C(N)NCCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-027148,
  title = {Cyclo(Trp-Arg), Diketopiperazine (WR)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-027148},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Cyclo(Trp-Arg), Diketopiperazine (WR). (2026). PepDiana record PEPDIA-INT-027148. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-027148

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (64 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P027148_ACT_camp_0000AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ13141camp / linked
CTPDB_P027148_ACT_camp_0001AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceCAMPSQ13141camp / linked
CTPDB_P027148_ACT_camp_0002AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ13141camp / linked
CTPDB_P027148_ACT_dbaasp_0016Antimicrobial->200 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_12469_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0017Antimicrobial->200 µg/mlStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_12469_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0018Antimicrobial->200 µg/mlStaphylococcus aureus ATCC 33591Not reported by sourceDBAASPS_12469_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0019Antimicrobial->200 µg/mlStaphylococcus epidermidis ATCC 27626Not reported by sourceDBAASPS_12469_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0020Antimicrobial->200 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_12470_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0021Antimicrobial-200 µg/mlStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_12470_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0022Antimicrobial-75 µg/mlStaphylococcus aureus ATCC 33591Not reported by sourceDBAASPS_12470_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0023Antimicrobial-75 µg/mlStaphylococcus epidermidis ATCC 27626Not reported by sourceDBAASPS_12470_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0024Antimicrobial-125 µg/mlBacillus subtilis MTCC 2756Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0025Antimicrobial-125 µg/mlBacillus subtilis MTCC 2756Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0026Antimicrobial-64 µg/mlStaphylococcus aureus MTCC 902Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0027Antimicrobial-64 µg/mlStaphylococcus aureus MTCC 902Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0028Antimicrobial-32 µg/mlStaphylococcus epidermidis MTCC 435Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0029Antimicrobial-64 µg/mlStaphylococcus epidermidis MTCC 435Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0030Antimicrobial-500 µg/mlEnterococcus faecalis MTCC 5383Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0031Antimicrobial-1000 µg/mlEnterococcus faecalis MTCC 5383Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0032Antimicrobial-250 µg/mlEnterococcus faecium MTCC 439Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0033Antimicrobial-250 µg/mlEnterococcus faecium MTCC 439Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0034Antimicrobial-250 µg/mlPseudomonas aeruginosa MTCC 2642Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0035Antimicrobial-500 µg/mlPseudomonas aeruginosa MTCC 2642Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0036Antimicrobial-1000 µg/mlProteus vulgaris MTCC 742Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0037Antimicrobial-1000 µg/mlProteus vulgaris MTCC 742Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0038Antimicrobial-1000 µg/mlProteus mirabilis MTCC 425Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0039Antimicrobial-2000 µg/mlProteus mirabilis MTCC 425Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0040Antimicrobial-125 µg/mlKlebsiella pneumoniae MTCC 109Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0041Antimicrobial-250 µg/mlKlebsiella pneumoniae MTCC 109Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0042Antimicrobial-125 µg/mlSalmonella enterica subsp. enterica serovar Typhi MTCC 3216Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0043Antimicrobial-250 µg/mlSalmonella enterica subsp. enterica serovar Typhi MTCC 3216Not reported by sourceDBAASPS_18887_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0044Antimicrobial-4 µg/mlBacillus subtilis MTCC 2756Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0045Antimicrobial-8 µg/mlBacillus subtilis MTCC 2756Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0046Antimicrobial-0.5 µg/mlStaphylococcus aureus MTCC 902Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0047Antimicrobial-0.5 µg/mlStaphylococcus aureus MTCC 902Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0048Antimicrobial-8 µg/mlStaphylococcus epidermidis MTCC 435Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0049Antimicrobial-16 µg/mlStaphylococcus epidermidis MTCC 435Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0050Antimicrobial-4 µg/mlEnterococcus faecalis MTCC 5383Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0051Antimicrobial-8 µg/mlEnterococcus faecalis MTCC 5383Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0052Antimicrobial-2 µg/mlEnterococcus faecium MTCC 439Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0053Antimicrobial-4 µg/mlEnterococcus faecium MTCC 439Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0054Antimicrobial-0.5 µg/mlPseudomonas aeruginosa MTCC 2642Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0055Antimicrobial-0.5 µg/mlPseudomonas aeruginosa MTCC 2642Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0056Antimicrobial-4 µg/mlProteus vulgaris MTCC 742Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0057Antimicrobial-8 µg/mlProteus vulgaris MTCC 742Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0058Antimicrobial-64 µg/mlProteus mirabilis MTCC 425Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0059Antimicrobial-128 µg/mlProteus mirabilis MTCC 425Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0060Antimicrobial-2 µg/mlKlebsiella pneumoniae MTCC 109Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0061Antimicrobial-4 µg/mlKlebsiella pneumoniae MTCC 109Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0062Antimicrobial-32 µg/mlSalmonella enterica subsp. enterica serovar Typhi MTCC 3216Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0063Antimicrobial-64 µg/mlSalmonella enterica subsp. enterica serovar Typhi MTCC 3216Not reported by sourceDBAASPS_18888_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0003Antimicrobial-3.1 µMStaphylococcus aureus USA 300Not reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0004Antimicrobial->50 µMPseudomonas aeruginosa PAO1Not reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0005Antimicrobial->50 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0006Antimicrobial->50 µMKlebsiella pneumoniaeNot reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0007Antimicrobial-6.25 µMStaphylococcus aureus USA 200Not reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0008Antimicrobial-6.25 µMStaphylococcus aureus USA 400Not reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0009Antimicrobial->12.5 µMStaphylococcus aureus UAMS-1Not reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0010Antimicrobial-3.1 µMStaphylococcus aureus MU50Not reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0011Antimicrobial-3.1-6.2 µMStaphylococcus aureus NewmanNot reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0012Antimicrobial-6.25 µMStaphylococcus epidermidisNot reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0013Antimicrobial->25 µMCandida albicans ATCC 10231Not reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0014Antimicrobial-25-50 µMCandida glabrata ATCC 2001Not reported by sourceDBAASPS_9827_chain0dbaasp / linked
CTPDB_P027148_ACT_dbaasp_0015Antimicrobial-12.5-25 µMCandida tropicalis ATCC 13803Not reported by sourceDBAASPS_9827_chain0dbaasp / linked

Provenance

Source database records (6)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

camp

CAMPSQ13141

Raw sequence

WR

dbaasp

DBAASPS_9827_chain0

Raw sequence

WR

dbaasp

DBAASPS_12469_chain0

Raw sequence

WR

dbaasp

DBAASPS_12470_chain0

Raw sequence

WR

dbaasp

DBAASPS_18887_chain0

Raw sequence

WR

dbaasp

DBAASPS_18888_chain0

Raw sequence

wr

Citation trail

Literature (4 records)

Small lipopeptides possess anti-biofilm capability comparable to daptomycin and vancomycin.

Mishra B, Lushnikova T, Wang G

RSC Adv2015PMID 26257894

The pharmacophore of short cationic antibacterial peptides.

Strøm MB, Haug BE, Skar ML, Stensen W, Stiberg T, Svendsen JS

J Med Chem2003PMID 12699374

Purification and synergistic antibacterial activity of arginine derived cyclic dipeptides, from Achromobacter sp. associated with a rhabditid entomopathogenic nematode against major clinically relevant biofilm forming wound bacteria.

Deepa I, Kumar SN, Sreerag RS, Nath VS, Mohandas C

Front Microbiol2015PMID 26379651

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:15.023171+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µM",
      "value": "19",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}
Source metadata
[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  }
]