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PEPDIA-INT-025687

Gold

Kalata-B1

85

Quality

7

Source DBs

97

Activities

17

Source refs

18

Literature

0

Patents

Integrated record

Sequence and molecular profile

GLPVCGETCVGGTCNTPGCTCSWPVCTRN
Indexed sequence29 aa
1GLPVCGETCVGGTCNTPGCTCSWPVCTRN

Length

29

Molecular weight

-

Formula

-

Structure type

Cyclic

Synthesis

Ribosomal

Chirality

L

Family

-

Gene

-

Residue composition

C
6
G
5
T
5
P
3
V
3
N
2
L
1
E
1
S
1
W
1
R
1

Physicochemical profile

Hydrophobic5

Membrane affinity proxy

Polar14

Solubility proxy

Charged2

Net charge proxy +0

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

partial sequence only structural context

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

2916.337 Da

Molecular formula

Not calculated

Theoretical pI

5.9623

Net charge at pH 7

-0.2965

GRAVY

0.1517

Instability index

46.5897

Aromaticity

0.0345

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

not generated modification context

Not calculated for this record

HELM 2.0

not generated modification context

Not calculated for this record

Canonical SMILES

not generated modification context

Not calculated for this record

Isomeric SMILES

not generated modification context

Not calculated for this record

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-025687,
  title = {Kalata-B1},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-025687},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Kalata-B1. (2026). PepDiana record PEPDIA-INT-025687. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-025687

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (97 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P025687_ACT_apd_0000AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceAP00729apd / linked
CTPDB_P025687_ACT_apd_0001Antiviral-Not available in the current structured importUnknownNot reported by sourceAP00729apd / linked
CTPDB_P025687_ACT_apd_0002AntimicrobialAntifungalNot available in the current structured importUnknownNot reported by sourceAP00729apd / linked
CTPDB_P025687_ACT_apd_0003AntimicrobialInsecticidalNot available in the current structured importUnknownNot reported by sourceAP00729apd / linked
CTPDB_P025687_ACT_apd_0004AntiviralAnti-HIVNot available in the current structured importUnknownNot reported by sourceAP00729apd / linked
CTPDB_P025687_ACT_apd_0005Enzyme InhibitorGeneral Enzyme InhibitorNot available in the current structured importUnknownNot reported by sourceAP00729apd / linked
CTPDB_P025687_ACT_apd_0006ToxicityHemolyticNot available in the current structured importUnknownNot reported by sourceAP00729apd / linked
CTPDB_P025687_ACT_camp_0012Antiviral-Not available in the current structured importUnknownNot reported by sourceCAMPSQ11010camp / linked
CTPDB_P025687_ACT_camp_0007AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ2869camp / linked
CTPDB_P025687_ACT_camp_0008AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceCAMPSQ2869camp / linked
CTPDB_P025687_ACT_camp_0009AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ2869camp / linked
CTPDB_P025687_ACT_camp_0010AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ9468camp / linked
CTPDB_P025687_ACT_camp_0011AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ9468camp / linked
CTPDB_P025687_ACT_dbaasp_0057Antimicrobial-0.9-2.5 µMHIV-1Not reported by sourceDBAASPS_5185_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0058Antimicrobial-6.3-10.5 µMHuman lymphoblastic leukemia Molt-4Not reported by sourceDBAASPS_5185_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0059Antimicrobial-2.04 µMHIV-1 NL4-3Not reported by sourceDBAASPS_5392_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0013Antimicrobial->500 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0014Antimicrobial->500 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0015Antimicrobial->500 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0016Antimicrobial->500 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0017Antimicrobial->500 µMProteus vulgaris ATCC 49132Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0018Antimicrobial->500 µMProteus vulgaris ATCC 49132Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0019Antimicrobial-54.8 µMKlebsiella oxytoca ATCC 49131Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0020Antimicrobial->500 µMKlebsiella oxytoca ATCC 49131Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0021Antimicrobial-0.26 µMStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0022Antimicrobial->500 µMStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0023Antimicrobial-40.4 µMMicrococcus luteus ATCC 49732Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0024Antimicrobial->500 µMMicrococcus luteus ATCC 49732Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0025Antimicrobial->500 µMCandida albicans ATCC 37092Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0026Antimicrobial->500 µMCandida albicans ATCC 37092Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0027Antimicrobial-21.4 µMCandida kefyr ATCC 37095Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0028Antimicrobial->500 µMCandida kefyr ATCC 37095Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0029Antimicrobial->500 µMCandida tropicalis ATCC 37097Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0030Antimicrobial->500 µMCandida tropicalis ATCC 37097Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0031Antimicrobial-3.10±0.06 µMHuman skin melanoma MM96LNot reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0032Antimicrobial-10.21±0.43 µMHuman cervical carcinoma HeLaNot reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0033Antimicrobial-1.32±0.15 µMHuman gastric cancer BGC-823Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0034Antimicrobial-40 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0035Antimicrobial-80 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0036Antimicrobial->160 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0037Antimicrobial->160 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0038Antimicrobial->160 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0039Antimicrobial-2.5 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0040Antimicrobial-10 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0041Antimicrobial-40 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0042Antimicrobial->160 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0043Antimicrobial->160 µMPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0044Antimicrobial-160 µMStaphylococcus aureus ATCC 33591Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0045Antimicrobial->160 µMStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0046Antimicrobial->160 µMStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0047Antimicrobial->160 µMCandida albicans ATCC 90028Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0048Antimicrobial->160 µMCandida albicans ATCC 90028Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0049Antimicrobial->160 µMCandida albicans ATCC 90028Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0050Antimicrobial-6.9 µMHuman histiocytic lymphoma U-937/GTBNot reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0051Antimicrobial-2.26 µMHaemonchus contortusNot reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0052Antimicrobial-7.13 µMTrichostrongylus colubriformisNot reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0053Antimicrobial-0.66 µMHIVNot reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0054Antimicrobial-16.6±0.6 µMHuman skin melanoma MM96LNot reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0055Antimicrobial-15.7±0.7 µMHuman cervical carcinoma HeLaNot reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dbaasp_0056Antimicrobial-13.1±0.4 µMHuman myelogenous leukemia K562Not reported by sourceDBAASPS_734_chain0dbaasp / linked
CTPDB_P025687_ACT_dramp_0060Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP00856dramp / linked
CTPDB_P025687_ACT_dramp_0061AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceDRAMP00856dramp / linked
CTPDB_P025687_ACT_dramp_0062AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceDRAMP00856dramp / linked
CTPDB_P025687_ACT_dramp_0063AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceDRAMP00856dramp / linked
CTPDB_P025687_ACT_dramp_0064AntimicrobialAntifungalNot available in the current structured importUnknownNot reported by sourceDRAMP00856dramp / linked
CTPDB_P025687_ACT_dramp_0065Antiviral-Not available in the current structured importUnknownNot reported by sourceDRAMP00856dramp / linked
CTPDB_P025687_ACT_dramp_0066Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP34326dramp / linked
CTPDB_P025687_ACT_dramp_0067Anticancer-Not available in the current structured importUnknownNot reported by sourceDRAMP34326dramp / linked
CTPDB_P025687_ACT_hemolytik_0071ToxicityHemolytic11.7 µMErythrocytesNot reported by source1025hemolytik / linked
CTPDB_P025687_ACT_hemolytik_0069ToxicityHemolytic25.0 µMErythrocytesNot reported by source3002hemolytik / linked
CTPDB_P025687_ACT_hemolytik_0070ToxicityHemolytic25.0 µMErythrocytesNot reported by source3015hemolytik / linked
CTPDB_P025687_ACT_hemolytik_0068ToxicityHemolytic1.1 µMErythrocytesNot reported by source4158hemolytik / linked
CTPDB_P025687_ACT_plantpepdb_0072AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0073AntimicrobialAntifungalNot available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0074Antiviral-Not available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0075Anticancer-Not available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0076ToxicityHemolyticNot available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0077AnticancerCytotoxicNot available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0078AntiparasiticNematocideNot available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0079UnknownMolluscicidalNot available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0080UnknownMembrane-BindingNot available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0081UnknownMetal-bindingNot available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0082AntimicrobialInsecticidalNot available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0083Enzyme InhibitorGeneral Enzyme InhibitorNot available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_plantpepdb_0084AntiviralAnti-HIVNot available in the current structured importUnknownNot reported by sourcePPepDB_2214plantpepdb / linked
CTPDB_P025687_ACT_satpdb_0086AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourcesatpdb19932satpdb / linked
CTPDB_P025687_ACT_satpdb_0087Antiviral-Not available in the current structured importUnknownNot reported by sourcesatpdb19932satpdb / linked
CTPDB_P025687_ACT_satpdb_0088ToxicityGeneral ToxicNot available in the current structured importUnknownNot reported by sourcesatpdb19932satpdb / linked
CTPDB_P025687_ACT_satpdb_0089Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb19932satpdb / linked
CTPDB_P025687_ACT_satpdb_0090Antiviral-Not available in the current structured importUnknownNot reported by sourcesatpdb20811satpdb / linked
CTPDB_P025687_ACT_satpdb_0091ToxicityGeneral ToxicNot available in the current structured importUnknownNot reported by sourcesatpdb20811satpdb / linked
CTPDB_P025687_ACT_satpdb_0092Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb20811satpdb / linked
CTPDB_P025687_ACT_satpdb_0093AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourcesatpdb25011satpdb / linked
CTPDB_P025687_ACT_satpdb_0094Antiviral-Not available in the current structured importUnknownNot reported by sourcesatpdb25011satpdb / linked
CTPDB_P025687_ACT_satpdb_0095ToxicityGeneral ToxicNot available in the current structured importUnknownNot reported by sourcesatpdb25011satpdb / linked
CTPDB_P025687_ACT_satpdb_0096Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb25011satpdb / linked
CTPDB_P025687_ACT_satpdb_0097AntimicrobialAntifungalNot available in the current structured importUnknownNot reported by sourcesatpdb25011satpdb / linked

Provenance

Source database records (17)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

apd

AP00729

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

camp

CAMPSQ2869

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

camp

CAMPSQ9468

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

camp

CAMPSQ11010

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

dbaasp

DBAASPS_734_chain0

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

dbaasp

DBAASPS_5185_chain0

Raw sequence

GlpvcGetcvGGtcntpGctcswpvctrn

dbaasp

DBAASPS_5392_chain0

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

dramp

DRAMP00856

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

dramp

DRAMP34326

Raw sequence

GlpvcGetcvGGtcntpGctcswpvctrn

hemolytik

4158

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

hemolytik

3002

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

hemolytik

3015

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

hemolytik

1025

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

plantpepdb

PPepDB_2214

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

satpdb

satpdb19932

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

satpdb

satpdb20811

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

satpdb

satpdb25011

Raw sequence

GLPVCGETCVGGTCNTPGCTCSWPVCTRN

Citation trail

Literature (18 records)

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.

Tam JP, Lu YA, Yang JL, Chiu KW.1999

Proc Natl Acad Sci U S A1999PMID 10430870

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.

Tam JP, Lu YA, Yang JL, Chiu KW

Proc Natl Acad Sci U S A1999PMID 21723349

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.

Tam JP, Lu YA, Yang JL, Chiu KW

Proc Natl Acad Sci U S A1999PMID 21928440

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.

Tam JP, Lu YA, Yang JL, Chiu KW

Proc Natl Acad Sci U S A1999PMID 21576247

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.

Tam JP, Lu YA, Yang JL, Chiu KW

Proc Natl Acad Sci U S A1999PMID 18618891

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.

Tam JP, Lu YA, Yang JL, Chiu KW

Proc Natl Acad Sci U S A1999PMID 25099014

Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1.##The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.##Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and ph

Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##Tam JP, Lu YA, Yang JL, Chiu KW.##Saether O, Craik DJ, Campbell ID, Sletten K, Juul J, Norman DG.##Plan MR, Göransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.##Wang CK, Wacklin HP, Craik DJ.

Biopolymers2008PMID 18008336

Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1.##The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.##Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and ph

Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##Tam JP, Lu YA, Yang JL, Chiu KW.##Saether O, Craik DJ, Campbell ID, Sletten K, Juul J, Norman DG.##Plan MR, Göransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.##Wang CK, Wacklin HP, Craik DJ.

Biopolymers2008PMID 7703226

Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1.##The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.##Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and ph

Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##Tam JP, Lu YA, Yang JL, Chiu KW.##Saether O, Craik DJ, Campbell ID, Sletten K, Juul J, Norman DG.##Plan MR, Göransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.##Wang CK, Wacklin HP, Craik DJ.

Biopolymers2008PMID 17534989

Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1.##The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.##Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and ph

Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##Tam JP, Lu YA, Yang JL, Chiu KW.##Saether O, Craik DJ, Campbell ID, Sletten K, Juul J, Norman DG.##Plan MR, Göransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.##Wang CK, Wacklin HP, Craik DJ.

Biopolymers2008PMID 23129773

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.203743+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µM",
      "value": "26",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "2.38±0.09",
      "source_db": "dbaasp",
      "assay_method": "IC50",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human foreskin fibroblasts (HFF)"
    },
    {
      "unit": "µM",
      "value": "25",
      "source_db": "dbaasp",
      "assay_method": "41% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "5.7",
      "source_db": "dbaasp",
      "assay_method": "IC50",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "CEM-SS cells"
    },
    {
      "unit": "µM",
      "value": "29.1±1.1",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "11.2±0.5",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human PBMC"
    },
    {
      "unit": "µM",
      "value": "12.0±0.5",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human foreskin fibroblasts (HFF)"
    },
    {
      "unit": "µM",
      "value": "77",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "25",
      "source_db": "dbaasp",
      "assay_method": "3% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.12779323] HD50 = 300 μM against Human type A red blood cells.",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.18008336]CEM-SS cells:IC50=3500 nM.",
      "toxicity_type": "Cytotoxic"
    }
  ]
}
Source metadata
[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "pdb_id": [
    "2KHB resolved by NMR.",
    "2JUE"
  ],
  "source_db": "dramp"
}