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PEPDIA-INT-025058

Gold

ACE inhibitory peptide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

MDFLI

Indexed sequence5 aa

1MDFLI

Length

Molecular weight

637.80 Da

Formula

C30H47N5O8S

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy -1

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

637.7877 Da

Molecular formula

C30H47N5O8S

Theoretical pI

4.05

Net charge at pH 7

-1.4985

GRAVY

1.9

Instability index

-7.08

Aromaticity

0.2

Topological polar surface area

217.02 Å²

cLogP

0.9002

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

MDFLI

HELM 2.0

validated simple linear

PEPTIDE1{M.D.F.L.I}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NC(=O)C(N)CCSC)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCSC)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-025058,
  title = {ACE inhibitory peptide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-025058},
  note = {Accessed from local PepDiana development build}
}

APA-style note

ACE inhibitory peptide. (2026). PepDiana record PEPDIA-INT-025058. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-025058

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (6 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P025058_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	0.11 mg/ml	Unknown	Hayakari et al. (1978)	1828ahtpdb / linked
CTPDB_P025058_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	0.01 µM	Unknown	Not reported by source	2295ahtpdb / linked
CTPDB_P025058_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	0.01 µM	Unknown	Not reported by source	6717ahtpdb / linked
CTPDB_P025058_ACT_plantpepdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	PPepDB_3796plantpepdb / linked
CTPDB_P025058_ACT_plantpepdb_0004	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	PPepDB_3796plantpepdb / linked
CTPDB_P025058_ACT_satpdb_0005	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb11317satpdb / linked

Provenance

Source database records (5)

ahtpdb

2295

Raw sequence

MDFLI

ahtpdb

1828

Raw sequence

MDFLI

ahtpdb

6717

Raw sequence

MDFLI

plantpepdb

PPepDB_3796

Raw sequence

MDFLI

satpdb

satpdb11317

Raw sequence

MDFLI

Citation trail

Literature (4 records)

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

Vegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities.

M C García, P Puchalska, C Esteve, M L Marina

Talanta 03/2013; 106C:328-349.2013PMID 23598136

Angiotensin converting enzyme inhibitory peptides derived from food proteins: biochemistry, bioactivity and production.

Murray BA1, FitzGerald RJ.

Curr Pharm Des. 2007;13(8):773-91.2007PMID 17430180

-

--PMID 24547749

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.113046+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSCC"
}