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PEPDIA-INT-024501

Gold

Unnamed peptide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

HLPLP

Indexed sequence5 aa

1HLPLP

Length

Molecular weight

575.71 Da

Formula

C28H45N7O6

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy +1

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

575.7002 Da

Molecular formula

C28H45N7O6

Theoretical pI

6.7411

Net charge at pH 7

-0.1527

GRAVY

0.24

Instability index

85.04

Aromaticity

Topological polar surface area

190.82 Å²

cLogP

0.4079

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HLPLP

HELM 2.0

validated simple linear

PEPTIDE1{H.L.P.L.P}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C1CCCN1C(=O)C(CC(C)C)NC(=O)C(N)Cc1c[nH]cn1)C(=O)N1CCCC1C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-024501,
  title = {Unnamed peptide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-024501},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Unnamed peptide. (2026). PepDiana record PEPDIA-INT-024501. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-024501

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (18 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P024501_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	51.88 µM	Unknown	Not reported by source	2423ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0004	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3456ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0005	Metabolic/Cardiovascular	ACE Inhibitor	41.0 µM	Unknown	Kasahara and Ashihara (1981)	3667ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Cushman and Cheung (1971)	4182ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	21.6 mM	Unknown	Cushman and Cheung (1971)	4186ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4477ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0006	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Cushman and Cheung (1971)	5002ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0007	Metabolic/Cardiovascular	ACE Inhibitor	41.0 µM	Unknown	Not reported by source	5316ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0008	Metabolic/Cardiovascular	ACE Inhibitor	41.0 µM	Unknown	Kasahara and Ashihara (1981)	6001ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0009	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Holmquist et al. (1979)	6054ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0010	Metabolic/Cardiovascular	ACE Inhibitor	41.0 µM	Unknown	Not reported by source	6329ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0011	Metabolic/Cardiovascular	ACE Inhibitor	41.0 µM	Unknown	Not reported by source	6787ahtpdb / linked
CTPDB_P024501_ACT_ahtpdb_0012	Metabolic/Cardiovascular	ACE Inhibitor	41.0 µM	Unknown	Kasahara and Ashihara (1981)	6826ahtpdb / linked
CTPDB_P024501_ACT_fermfoodb_0013	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	RP-HPLC-MS/MS	FermFooDB_Casein_FMDB1850fermfoodb / linked
CTPDB_P024501_ACT_fermfoodb_0014	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	RP-HPLC-MS/MS	FermFooDB_Casein_FMDB1889fermfoodb / linked
CTPDB_P024501_ACT_fermfoodb_0016	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	RP-HPLC-MS/MS	FermFooDB_milk_FMDB1850fermfoodb / linked
CTPDB_P024501_ACT_fermfoodb_0015	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	RP-HPLC-MS/MS	FermFooDB_milk_FMDB1889fermfoodb / linked
CTPDB_P024501_ACT_satpdb_0017	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb15788satpdb / linked

Provenance

Source database records (19)

ahtpdb

4182

Raw sequence

HLPLP

ahtpdb

4186

Raw sequence

HLPLP

ahtpdb

4477

Raw sequence

HLPLP

ahtpdb

2423

Raw sequence

HLPLP

ahtpdb

6001

Raw sequence

HLPLP

ahtpdb

6054

Raw sequence

HLPLP

ahtpdb

6329

Raw sequence

HLPLP

ahtpdb

6787

Raw sequence

HLPLP

ahtpdb

6826

Raw sequence

HLPLP

ahtpdb

5002

Raw sequence

HLPLP

ahtpdb

5316

Raw sequence

HLPLP

ahtpdb

3456

Raw sequence

HLPLP

ahtpdb

3667

Raw sequence

HLPLP

fermfoodb

FermFooDB_Casein_FMDB1850

Raw sequence

HLPLP

fermfoodb

FermFooDB_Casein_FMDB1889

Raw sequence

HLPLP

fermfoodb

FermFooDB_Casein_FMDB2153

Raw sequence

HLPLP

fermfoodb

FermFooDB_milk_FMDB1889

Raw sequence

HLPLP

fermfoodb

FermFooDB_milk_FMDB1850

Raw sequence

HLPLP

satpdb

satpdb15788

Raw sequence

HLPLP

Citation trail

Literature (11 records)

Antihypertensive peptides from food proteins: a review.

Martínez-Maqueda D1, Miralles B, Recio I, Hernández-Ledesma B.

Food Funct. 2012 Apr;3(4):350-61.2012PMID 22249830

Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats

Marta Miguel et al.,

Mol. Nutr. Food Res., 2010, 54, 1422–1427.2010PMID 20397194

Primary and secondary structure of novel ACE-inhibitory peptides from egg white protein

Zhipeng Yu et al.

Food Chemistry 133(2), 15 July 2012, Pages 315–3222012

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

Inhibition of angiotensin I-converting enzyme by synthetic peptides of human ?-casein

Kohmura, M. et al.,

Agric Biol Chem 53 p.2107-21141989PMID 1368548

Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765

Robert, M.C. Et al.,

J Agric Food Chem 52 p.6923-312004PMID 15537298

Inhibition of Angiotensin-converting Enzyme by Synthetic Peptides of Human ?-Casein

Masanori KOHMURA et al.

Agric Biol Chem. 53(8):2107-2114.1989

The potential role of milk-derived peptides in cardiovascular disease.

Phelan M1, Kerins D.

Food Funct. 2011 Apr;2(3-4):153-67.2011PMID 21779574

Is the structural diversity of tripeptides sufficient for developing functional food additives with satisfactory multiple bioactivities?

Jian-Hui Wang et al.,

Journal of Molecular Structure 1040 (2013) 164-1702013

Integration of QSAR modelling and QM/MM analysis to investigate functional food peptides with antihypertensive activity

Jin Tan et al.

Molecular Simulation Volume 39, Issue 12, 20132013

Animal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation

Anna Iwaniak and Jerzy Dziuba

Food Technol. Biotechnol. 47 (4) 441–449 (2009)2009

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "fermfoodb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSCC"
}