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PEPDIA-INT-021938

Gold

Melanotropin alpha, alpha-MSH

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

SYSMEHFRWGKPV

Indexed sequence13 aa

1SYSMEHFRWGKPV

Length

Molecular weight

1623.86 Da

Formula

C75H106N20O19S

Structure type

Linear

Synthesis

Ribosomal

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic5

Membrane affinity proxy

Polar2

Solubility proxy

Charged4

Net charge proxy +2

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1623.8316 Da

Molecular formula

C75H106N20O19S

Theoretical pI

8.3342

Net charge at pH 7

0.5481

GRAVY

-0.9231

Instability index

34.0231

Aromaticity

0.2308

Topological polar surface area

634.11 Å²

cLogP

-4.1149

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

SYSMEHFRWGKPV

HELM 2.0

validated simple linear

PEPTIDE1{S.Y.S.M.E.H.F.R.W.G.K.P.V}$$$$V2.0

Canonical SMILES

validated

CSCCC(NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CO)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C(=O)O)C(C)C

Isomeric SMILES

validated

CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-021938,
  title = {Melanotropin alpha, alpha-MSH},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-021938},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Melanotropin alpha, alpha-MSH. (2026). PepDiana record PEPDIA-INT-021938. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-021938

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (34 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P021938_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP00449apd / linked
CTPDB_P021938_ACT_apd_0001	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	AP00449apd / linked
CTPDB_P021938_ACT_apd_0002	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP00449apd / linked
CTPDB_P021938_ACT_apd_0004	Antiviral	Anti-HIV	Not available in the current structured import	Unknown	Not reported by source	AP00449apd / linked
CTPDB_P021938_ACT_camp_0005	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ2779camp / linked
CTPDB_P021938_ACT_camp_0006	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ2779camp / linked
CTPDB_P021938_ACT_dbaasp_0007	Antimicrobial	-	>100 µM	Bacillus subtilis ATCC 9372	Not reported by source	DBAASPS_7450_chain0dbaasp / linked
CTPDB_P021938_ACT_dbaasp_0008	Antimicrobial	-	>100 µM	Bacillus anthracis Sterne 34F2	Not reported by source	DBAASPS_7450_chain0dbaasp / linked
CTPDB_P021938_ACT_dbaasp_0009	Antimicrobial	-	>50 µM	Burkholderia thailandensis	Not reported by source	DBAASPS_7450_chain0dbaasp / linked
CTPDB_P021938_ACT_dramp_0010	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP02876dramp / linked
CTPDB_P021938_ACT_dramp_0011	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP02876dramp / linked
CTPDB_P021938_ACT_dramp_0012	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP02876dramp / linked
CTPDB_P021938_ACT_dramp_0016	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP13525dramp / linked
CTPDB_P021938_ACT_dramp_0017	Unknown	anti-candidal	Not available in the current structured import	Unknown	Not reported by source	DRAMP18083dramp / linked
CTPDB_P021938_ACT_dramp_0013	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP18833dramp / linked
CTPDB_P021938_ACT_dramp_0014	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP18833dramp / linked
CTPDB_P021938_ACT_dramp_0015	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP18833dramp / linked
CTPDB_P021938_ACT_parapep_0018	Antiparasitic	Antiparasitic	95.0 µM	Unknown	MTT assay	1325parapep / linked
CTPDB_P021938_ACT_parapep_0019	Antiparasitic	Antiparasitic	8.9 µM	Unknown	MTT assay	1326parapep / linked
CTPDB_P021938_ACT_satpdb_0020	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb14824satpdb / linked
CTPDB_P021938_ACT_satpdb_0021	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb14893satpdb / linked
CTPDB_P021938_ACT_satpdb_0022	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb14893satpdb / linked
CTPDB_P021938_ACT_satpdb_0023	Bioregulatory	Cell-Cell Communication	Not available in the current structured import	Unknown	Not reported by source	satpdb14893satpdb / linked
CTPDB_P021938_ACT_satpdb_0024	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb14893satpdb / linked
CTPDB_P021938_ACT_satpdb_0025	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb14893satpdb / linked
CTPDB_P021938_ACT_satpdb_0026	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb18067satpdb / linked
CTPDB_P021938_ACT_satpdb_0027	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb18067satpdb / linked
CTPDB_P021938_ACT_satpdb_0028	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb18067satpdb / linked
CTPDB_P021938_ACT_satpdb_0029	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb18067satpdb / linked
CTPDB_P021938_ACT_topicalpdb_0030	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	10-7 and 10-8 concentrations turned yellow hair brown; Light and electron microscopy; in vivo	1301topicalpdb / linked
CTPDB_P021938_ACT_topicalpdb_0031	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Concentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application.; Electron microscopy and Light microscopy; in vitro	1305topicalpdb / linked
CTPDB_P021938_ACT_topicalpdb_0032	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Minimal effective dose=10-8to10-9M. It stimulated eumelanogenesis in all hair emerging from the areas previously plucked.; Electron microscopic examination; in vivo	1309topicalpdb / linked
CTPDB_P021938_ACT_topicalpdb_0033	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Phenotypic markers: Ia=408 ± 19 , Thy1.2=340 ± 15 and Asialo GM-1=465 ± 18; Indirect immunoperoxidase and indirect immunofluorescence staining; in vivo	1317topicalpdb / linked
CTPDB_P021938_ACT_topicalpdb_0034	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Osmolarity measurements: t=0 min., α-MSH/Buffer=310/311mOsm/l; t=6 min., α-MSH/Buffer=301/306mOsm/l; t=16 min., α-MSH/Buffer=305/308mOsm/l; Volume measurement: α-MSH/Buffer= 17.5µl/6.2µl; Osmolarity and tear volume measurements; in vivo	1433topicalpdb / linked

Provenance

Source database records (18)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

apd

AP00449

Raw sequence

SYSMEHFRWGKPV

b3pdb

b3pdb_0675

Raw sequence

Ac-SYSMEHFRWGKPV

camp

CAMPSQ2779

Raw sequence

SYSMEHFRWGKPV

dbaasp

DBAASPS_7450_chain0

Raw sequence

SYSMEHFRWGKPV

dramp

DRAMP02876

Raw sequence

SYSMEHFRWGKPV

dramp

DRAMP18833

Raw sequence

SYSMEHFRWGKPV

dramp

DRAMP13525

Raw sequence

SYSMEHFRWGKPV

dramp

DRAMP18083

Raw sequence

SYSMEHFRWGKPV

parapep

1325

Raw sequence

SYSMEHFRWGKPV

parapep

1326

Raw sequence

SYSMEHFRWGKPV

satpdb

satpdb14824

Raw sequence

SYSMEHFRWGKPV

satpdb

satpdb14893

Raw sequence

SYSMEHFRWGKPV

satpdb

satpdb18067

Raw sequence

SYSMEHFRWGKPV

topicalpdb

1301

Raw sequence

SYSMEHFRWGKPV

topicalpdb

1305

Raw sequence

SYSMEHFRWGKPV

topicalpdb

1309

Raw sequence

SYSMEHFRWGKPV

topicalpdb

1317

Raw sequence

SYSMEHFRWGKPV

topicalpdb

1433

Raw sequence

SYSMEHFRWGKPV

Citation trail

Literature (11 records)

{"reference": "J Leukoc Biol 2000; 67(2): 233-9", "title": "Antimicrobial effects of alpha-MSH peptides.", "author": "Cutuli M, Cristiani S, Lipton JM, Catania A.2000"}

-

--PMID 2413968

-

--PMID 10670585

Characterisation and evaluation of synthetic antimicrobial peptides against Bacillus globigii, Bacillus anthracis and Burkholderia thailandensis.

Dawson RM, McAllister J, Liu CQ

Int J Antimicrob Agents2010PMID 20692130

{"reference": "Antimicrobial peptides: therapeutic potential. Expert Opin. Pharmacother. (2006)."}

IP evidence

Patents (2)

US 7244710

dramp

US 6803044

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.941613+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": ">100",
      "source_db": "dbaasp",
      "assay_method": "1% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "b3pdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "topicalpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCSCTTTSCCCC"
}