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PEPDIA-INT-020931

Gold

p2(gag) peptide[Δ10-14]

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

AEAMSQVTN

Indexed sequence9 aa

1AEAMSQVTN

Length

Molecular weight

950.04 Da

Formula

C37H63N11O16S

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar4

Solubility proxy

Charged1

Net charge proxy -1

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

950.0251 Da

Molecular formula

C37H63N11O16S

Theoretical pI

4.05

Net charge at pH 7

-1.2013

GRAVY

-0.2556

Instability index

44.6

Aromaticity

Topological polar surface area

460.06 Å²

cLogP

-6.8956

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

AEAMSQVTN

HELM 2.0

validated simple linear

PEPTIDE1{A.E.A.M.S.Q.V.T.N}$$$$V2.0

Canonical SMILES

validated

CSCCC(NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C)N)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(C(=O)NC(C(=O)NC(CC(N)=O)C(=O)O)C(C)O)C(C)C

Isomeric SMILES

validated

CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)O)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-020931,
  title = {p2(gag) peptide[Δ10-14]},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-020931},
  note = {Accessed from local PepDiana development build}
}

APA-style note

p2(gag) peptide[Δ10-14]. (2026). PepDiana record PEPDIA-INT-020931. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-020931

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (9 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P020931_ACT_camp_0002	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ21474camp / linked
CTPDB_P020931_ACT_camp_0003	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ21474camp / linked
CTPDB_P020931_ACT_dbaasp_0004	Antimicrobial	-	5 µM	HIV-1	Not reported by source	DBAASPS_6010_chain0dbaasp / linked
CTPDB_P020931_ACT_dramp_0005	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP30285dramp / linked
CTPDB_P020931_ACT_dramp_0006	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP30285dramp / linked
CTPDB_P020931_ACT_hipdb_0001	Antiviral	Anti-HIV	Medium	HIV	Not reported by source	HIPdb_HIP1066hipdb / unavailable
CTPDB_P020931_ACT_hipdb_0000	Antiviral	Anti-HIV	5.0 μM	HIV	Not reported by source	HIPdb_HIP144hipdb / unavailable
CTPDB_P020931_ACT_satpdb_0007	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb22640satpdb / linked
CTPDB_P020931_ACT_satpdb_0008	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb22640satpdb / linked

Provenance

Source database records (6)

hipdb

HIPdb_HIP144

Raw sequence

AEAMSQVTN

hipdb

HIPdb_HIP1066

Raw sequence

AEAMSQVTN

camp

CAMPSQ21474

Raw sequence

AEAMSQVTN

dbaasp

DBAASPS_6010_chain0

Raw sequence

AEAMSQVTN

dramp

DRAMP30285

Raw sequence

AEAMSQVTN

satpdb

satpdb22640

Raw sequence

AEAMSQVTN

Citation trail

Literature (3 records)

{"pubmed_id": "15113844.0", "paper": "Blocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide.", "authors": "Misumi S, Morikawa Y, Tomonaga M, Ohkuma K, Takamune N, Shoji S.", "reference": "J Biochem. 2004 Mar;135(3):447-53."}

{"pubmed_id": "15113844.0", "paper": "Blocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide.", "authors": "Misumi S, Morikawa Y, Tomonaga M, Ohkuma K, Takamune N, Shoji S.", "reference": "J Biochem. 2004 Mar;135(3):447-53."}

{"pubmed_id": "9425262.0", "paper": "The p2gag peptide, AEAMSQVTNTATIM, processed from HIV-1 Pr55gag was found to be a suicide inhibitor of HIV-1 protease.", "authors": "Misumi S, Kudo A, Azuma R, Tomonaga M, Furuishi K, Shoji S.", "reference": "Biochem Biophys Res Commun. 1997 Dec 18;241(2):275-80."}

{"pubmed_id": "9425262.0", "paper": "The p2gag peptide, AEAMSQVTNTATIM, processed from HIV-1 Pr55gag was found to be a suicide inhibitor of HIV-1 protease.", "authors": "Misumi S, Kudo A, Azuma R, Tomonaga M, Furuishi K, Shoji S.", "reference": "Biochem Biophys Res Commun. 1997 Dec 18;241(2):275-80."}

-

--PMID 15113844

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:13.525035+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "hipdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCSSSTTC"
}