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PEPDIA-INT-020517

Bronze

Melittin [K7E]

45

Quality

1

Source DBs

0

Activities

1

Source refs

1

Literature

0

Patents

Integrated record

Sequence and molecular profile

GIGAVLEVLTTGLPALISWIKRKRQQ
Indexed sequence26 aa
1GIGAVLEVLTTGLPALISWIKRKRQQ

Length

26

Molecular weight

2848.44 Da

Formula

C130H223N37O34

Structure type

-

Synthesis

Synthetic

Chirality

-

Family

-

Gene

-

Residue composition

L
4
G
3
I
3
A
2
V
2
T
2
K
2
R
2
Q
2
E
1
P
1
S
1

Physicochemical profile

Hydrophobic12

Membrane affinity proxy

Polar5

Solubility proxy

Charged5

Net charge proxy +3

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

2848.3888 Da

Molecular formula

C130H223N37O34

Theoretical pI

11.0004

Net charge at pH 7

2.7609

GRAVY

0.2885

Instability index

51.2615

Aromaticity

0.0385

Topological polar surface area

1157.83 Ų

cLogP

-8.7486

Hydrogen-bond donors

41

Hydrogen-bond acceptors

37

Rotatable bonds

96

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

GIGAVLEVLTTGLPALISWIKRKRQQ

HELM 2.0

validated simple linear

PEPTIDE1{G.I.G.A.V.L.E.V.L.T.T.G.L.P.A.L.I.S.W.I.K.R.K.R.Q.Q}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)CN)C(=O)NCC(=O)NC(C)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CO)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(N)=O)C(=O)NC(CCC(N)=O)C(=O)O)C(C)CC)C(C)CC)C(C)O)C(C)O)C(C)C)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)CN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-020517,
  title = {Melittin [K7E]},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-020517},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Melittin [K7E]. (2026). PepDiana record PEPDIA-INT-020517. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-020517

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Provenance

Source database records (1)

dbaasp

DBAASPS_1792_chain0

Raw sequence

GIGAVLEVLTTGLPALISWIKRKRQQ

Citation trail

Literature (1 records)

The role of amphipathicity in the folding, self-association and biological activity of multiple subunit small proteins.

Pérez-Payá E, Houghten RA, Blondelle SE

J Biol Chem1995PMID 7836358

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:17.814455+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "4.0",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "4.4",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}
Source metadata
[
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  }
]