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PEPDIA-INT-019968

Gold

Angiotensin I-converting enzyme inhibitor 7

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

IYPRY

Indexed sequence5 aa

1IYPRY

Length

Molecular weight

710.83 Da

Formula

C35H50N8O8

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic3

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy +1

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

710.8202 Da

Molecular formula

C35H50N8O8

Theoretical pI

8.5897

Net charge at pH 7

0.7581

GRAVY

-0.84

Instability index

2.52

Aromaticity

0.4

Topological polar surface area

273.29 Å²

cLogP

0.0497

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

IYPRY

HELM 2.0

validated simple linear

PEPTIDE1{I.Y.P.R.Y}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(N)C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccc(O)cc1)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-019968,
  title = {Angiotensin I-converting enzyme inhibitor 7},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-019968},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Angiotensin I-converting enzyme inhibitor 7. (2026). PepDiana record PEPDIA-INT-019968. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-019968

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (12 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P019968_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	4.1 µM	Unknown	Not reported by source	1670ahtpdb / linked
CTPDB_P019968_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Cushman and Cheung (1971)	1920ahtpdb / linked
CTPDB_P019968_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	6.3 µM	Unknown	Not reported by source	2346ahtpdb / linked
CTPDB_P019968_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	4.1 µM	Unknown	Not reported by source	4999ahtpdb / linked
CTPDB_P019968_ACT_ahtpdb_0004	Metabolic/Cardiovascular	ACE Inhibitor	8.5 µM	Unknown	Not reported by source	5324ahtpdb / linked
CTPDB_P019968_ACT_ahtpdb_0005	Metabolic/Cardiovascular	ACE Inhibitor	4.1 µM	Unknown	Not reported by source	5571ahtpdb / linked
CTPDB_P019968_ACT_ahtpdb_0006	Metabolic/Cardiovascular	ACE Inhibitor	8.5 µM	Unknown	Cushman and Cheung (1971)	6154ahtpdb / linked
CTPDB_P019968_ACT_ahtpdb_0007	Metabolic/Cardiovascular	ACE Inhibitor	4.1 µM	Unknown	Not reported by source	6410ahtpdb / linked
CTPDB_P019968_ACT_plantpepdb_0008	Enzyme Inhibitor	General Enzyme Inhibitor	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2974plantpepdb / linked
CTPDB_P019968_ACT_plantpepdb_0009	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	PPepDB_2974plantpepdb / linked
CTPDB_P019968_ACT_plantpepdb_0010	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	PPepDB_2974plantpepdb / linked
CTPDB_P019968_ACT_satpdb_0011	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb21529satpdb / linked

Provenance

Source database records (10)

ahtpdb

4999

Raw sequence

IYPRY

ahtpdb

2346

Raw sequence

IYPRY

ahtpdb

1670

Raw sequence

IYPRY

ahtpdb

1920

Raw sequence

IYPRY

ahtpdb

6154

Raw sequence

IYPRY

ahtpdb

6410

Raw sequence

IYPRY

ahtpdb

5324

Raw sequence

IYPRY

ahtpdb

5571

Raw sequence

IYPRY

plantpepdb

PPepDB_2974

Raw sequence

IYPRY

satpdb

satpdb21529

Raw sequence

IYPRY

Citation trail

Literature (8 records)

Is the structural diversity of tripeptides sufficient for developing functional food additives with satisfactory multiple bioactivities?

Jian-Hui Wang et al.,

Journal of Molecular Structure 1040 (2013) 164-1702013

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

Antihypertensive Peptides Specific to Lactobacillus helveticus Fermented Milk

Taketo Wakai and Naoyuki Yamamoto

Biotechnology - Molecular Studies and Novel Applications for Improved Quality of Human Life Edited by Reda Helmy Sammour, ISBN 978-953-51-0151-2, 250 pages2012

Vegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities.

M C García, P Puchalska, C Esteve, M L Marina

Talanta 03/2013; 106C:328-349.2013PMID 23598136

Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees

Saito, Y et al.,

Biosc Biotechnol Biochem 58 p.1767-711994PMID 7765503

Integration of QSAR modelling and QM/MM analysis to investigate functional food peptides with antihypertensive activity

Jin Tan et al.

Molecular Simulation Volume 39, Issue 12, 20132013

12. Functional Food Products with Antihypertensive Effects

Naoyuki Yamamoto

Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals2010

-

--PMID 28317757

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.113046+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCC"
}