ProForma 2.0
validated simple linear
IIGGR
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PEPDIA-INT-019318
SilverPepDiana tier derived from the internal quality score plus activity and literature coverage; it is not an external database rating.Cathepsin G(1-5) (natural AMPs; human, primates, mammals, animals)
65
Quality PepDiana 0–100 composite of sequence, source, activity, literature, and cross-database evidence completeness.
2
Source DBs
8
Activities
4
Source refs
1
Literature
2
Patents
Integrated record
Sequence and molecular profile
IIGGR
Indexed sequence5 aa
1IIGGR
Length
5
Molecular weight
514.63 Da
Formula
C22H42N8O6
Structure type
-
Synthesis
-
Chirality
Mixed
Family
-
Gene
-
Residue composition
I
2
G
2
R
1
Physicochemical profile
Hydrophobic2
Membrane affinity proxy
Polar0
Solubility proxy
Charged1
Net charge proxy +1
Aromatic0
Binding interaction proxy
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.
Computed properties
physchem-20260620Molecular weight
514.6188 Da
Molecular formula
C22H42N8O6
Theoretical pI
9.75
Net charge at pH 7
0.7601
GRAVY
0.74
Instability index
32.68
Aromaticity
0
Topological polar surface area
241.62 Ų
cLogP
-2.0442
Hydrogen-bond donors
9
Hydrogen-bond acceptors
7
Rotatable bonds
17
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{I.I.G.G.R}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(N)C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)O)C(C)CC
Isomeric SMILES
validated
CC[C@H](C)[C@H](N)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)CC
Follow-up research
External analysis tools
Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.
Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.
Research workflow
Citation and local history
BibTeX
@misc{PEPDIA-INT-019318,
title = {Cathepsin G(1-5) (natural AMPs; human, primates, mammals, animals)},
author = {{PepDiana Consortium}},
year = {2026},
howpublished = {PepDiana Multifunctional Peptide Database},
url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-019318},
note = {Accessed from local PepDiana development build}
}APA-style note
Cathepsin G(1-5) (natural AMPs; human, primates, mammals, animals). (2026). PepDiana record PEPDIA-INT-019318. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-019318
This record is saved to local recent-view history so it can reappear on the peptide browser page.
Integrated source-database annotations
Biological activity (8 records)
| Stable record | Activity | Subtype | Value | Target | Assay method | Source |
|---|---|---|---|---|---|---|
| CTPDB_P019318_ACT_apd_0000 | Antimicrobial | Anti-Gram+ | Not available in the current structured import | Unknown | Not reported by source | AP00334apd / linked |
| CTPDB_P019318_ACT_dramp_0005 | Antimicrobial | - | Not available in the current structured import | Unknown | Not reported by source | DRAMP12903dramp / linked |
| CTPDB_P019318_ACT_dramp_0001 | Antimicrobial | - | Not available in the current structured import | Unknown | Not reported by source | DRAMP18714dramp / linked |
| CTPDB_P019318_ACT_dramp_0002 | Antimicrobial | Antibacterial | Not available in the current structured import | Unknown | Not reported by source | DRAMP18714dramp / linked |
| CTPDB_P019318_ACT_dramp_0003 | Antimicrobial | Anti-Gram+ | Not available in the current structured import | Unknown | Not reported by source | DRAMP18714dramp / linked |
| CTPDB_P019318_ACT_dramp_0004 | Antimicrobial | Anti-Gram- | Not available in the current structured import | Unknown | Not reported by source | DRAMP18714dramp / linked |
| CTPDB_P019318_ACT_dramp_0006 | Antimicrobial | - | Not available in the current structured import | Unknown | Not reported by source | DRAMP19251dramp / linked |
| CTPDB_P019318_ACT_dramp_0007 | Antimicrobial | Antibacterial | Not available in the current structured import | Unknown | Not reported by source | DRAMP19251dramp / linked |
Provenance
Source database records (4)
Citation trail
Literature (1 records)
Identification of the primary antimicrobial domains in human neutrophil cathepsin G.
Bangalore N1, Travis J, Onunka VC, Pohl J, Shafer WM.1990
IP evidence
Patents (2)
US 5447914
dramp
US 5798336
dramp
Audit surface
Raw annotations and release metadata
Integrated record last updated: 2026-04-15T00:59:11.941613+00:00
Modification summary
No structured modification annotations are available for this record.
Source metadata
[
{
"source_db": "apd",
"organism_name": "Unknown"
},
{
"source_db": "dramp",
"organism_name": "Unknown"
}
]