ProForma 2.0
validated simple linear
GTYLYPFSYYRLWRYFTRFLHKQPYYYVHI
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PEPDIA-INT-018810
GoldPepDiana tier derived from the internal quality score plus activity and literature coverage; it is not an external database rating.Y-Fe1
80
Quality PepDiana 0–100 composite of sequence, source, activity, literature, and cross-database evidence completeness.
3
Source DBs
7
Activities
3
Source refs
1
Literature
0
Patents
Integrated record
Sequence and molecular profile
GTYLYPFSYYRLWRYFTRFLHKQPYYYVHI
Indexed sequence30 aa
1GTYLYPFSYYRLWRYFTRFLHKQPYYYVHI
Length
30
Molecular weight
4042.67 Da
Formula
C203H270N46O43
Structure type
Linear
Synthesis
-
Chirality
-
Family
-
Gene
-
Residue composition
Y
8
L
3
F
3
R
3
T
2
P
2
H
2
G
1
S
1
W
1
K
1
Q
1
Physicochemical profile
Hydrophobic17
Membrane affinity proxy
Polar4
Solubility proxy
Charged6
Net charge proxy +6
Aromatic14
Binding interaction proxy
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.
Computed properties
physchem-20260620Molecular weight
4042.5976 Da
Molecular formula
C203H270N46O43
Theoretical pI
9.6972
Net charge at pH 7
3.9254
GRAVY
-0.53
Instability index
66.2933
Aromaticity
0.4
Topological polar surface area
1440.13 Ų
cLogP
-2.15
Hydrogen-bond donors
54
Hydrogen-bond acceptors
49
Rotatable bonds
116
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{G.T.Y.L.Y.P.F.S.Y.Y.R.L.W.R.Y.F.T.R.F.L.H.K.Q.P.Y.Y.Y.V.H.I}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)C(Cc1c[nH]cn1)NC(=O)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C1CCCN1C(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1ccccc1)NC(=O)C1CCCN1C(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)CN)C(C)O)C(C)O)C(C)C)C(=O)O
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)O
Follow-up research
External analysis tools
Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.
Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.
Research workflow
Citation and local history
BibTeX
@misc{PEPDIA-INT-018810,
title = {Y-Fe1},
author = {{PepDiana Consortium}},
year = {2026},
howpublished = {PepDiana Multifunctional Peptide Database},
url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-018810},
note = {Accessed from local PepDiana development build}
}APA-style note
Y-Fe1. (2026). PepDiana record PEPDIA-INT-018810. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-018810
This record is saved to local recent-view history so it can reappear on the peptide browser page.
Integrated source-database annotations
Biological activity (7 records)
| Stable record | Activity | Subtype | Value | Target | Assay method | Source |
|---|---|---|---|---|---|---|
| CTPDB_P018810_ACT_conoserver_0000 | Neuroactive/Ion Channel | Toxin | Not available in the current structured import | Voltage-Gated Potassium Channels | Not reported by source | P05237conoserver / linked |
| CTPDB_P018810_ACT_kalium_0001 | Neuroactive/Ion Channel | Ion Channel Modulator | Not available in the current structured import | [Kv1.2](https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=539) | Not reported by source | 324kalium / linked |
| CTPDB_P018810_ACT_kalium_0002 | Neuroactive/Ion Channel | Ion Channel Modulator | Not available in the current structured import | [Kv1.3](https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=540) | Not reported by source | 324kalium / linked |
| CTPDB_P018810_ACT_kalium_0003 | Neuroactive/Ion Channel | Ion Channel Modulator | Not available in the current structured import | [Kv1.4](https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=541) | Not reported by source | 324kalium / linked |
| CTPDB_P018810_ACT_kalium_0004 | Neuroactive/Ion Channel | Ion Channel Modulator | Not available in the current structured import | [Kv1.5](https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=542) | Not reported by source | 324kalium / linked |
| CTPDB_P018810_ACT_kalium_0005 | Neuroactive/Ion Channel | Ion Channel Modulator | 8800.0 nM | [Kv1.6](https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=543) | Not reported by source | 324kalium / linked |
| CTPDB_P018810_ACT_satpdb_0006 | Toxicity | General Toxic | Not available in the current structured import | Unknown | Not reported by source | satpdb21094satpdb / linked |
Provenance
Source database records (3)
Citation trail
Literature (1 records)
-
-
Audit surface
Raw annotations and release metadata
Integrated record last updated: 2026-04-15T00:59:17.112460+00:00
Modification summary
No structured modification annotations are available for this record.
Source metadata
[
{
"source_db": "conoserver",
"organism_name": "Unknown"
},
{
"source_db": "kalium",
"organism_name": "Unknown"
},
{
"source_db": "satpdb",
"organism_name": "Unknown"
}
]Structure metadata
{
"source_db": "satpdb",
"dssp_states": "CCSSSSCCHHHHHHHSBCSSSTTTSBCCCC"
}