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PEPDIA-INT-018639

Gold

Angiotensin I-converting enzyme inhibitor 14

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

TYLGS

Indexed sequence5 aa

1TYLGS

Length

Molecular weight

539.59 Da

Formula

C24H37N5O9

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar2

Solubility proxy

Charged0

Net charge proxy +0

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

539.5786 Da

Molecular formula

C24H37N5O9

Theoretical pI

5.1849

Net charge at pH 7

-0.6028

GRAVY

0.12

Instability index

Aromaticity

0.2

Topological polar surface area

240.41 Å²

cLogP

-2.6636

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

TYLGS

HELM 2.0

validated simple linear

PEPTIDE1{T.Y.L.G.S}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)C(C)O)C(=O)NCC(=O)NC(CO)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-018639,
  title = {Angiotensin I-converting enzyme inhibitor 14},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-018639},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Angiotensin I-converting enzyme inhibitor 14. (2026). PepDiana record PEPDIA-INT-018639. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-018639

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (4 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P018639_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	2.56 µM	Unknown	Not reported by source	2320ahtpdb / linked
CTPDB_P018639_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	0.86 µM	Unknown	Not reported by source	2865ahtpdb / linked
CTPDB_P018639_ACT_plantpepdb_0002	Enzyme Inhibitor	General Enzyme Inhibitor	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2853plantpepdb / linked
CTPDB_P018639_ACT_satpdb_0003	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb15818satpdb / linked

Provenance

Source database records (4)

ahtpdb

2320

Raw sequence

TYLGS

ahtpdb

2865

Raw sequence

TYLGS

plantpepdb

PPepDB_2853

Raw sequence

TYLGS

satpdb

satpdb15818

Raw sequence

TYLGS

Citation trail

Literature (3 records)

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

Inhibition strength of short peptides derived from an ACE inhibitory peptide.

Terashima M1, Oe M, Ogura K, Matsumura S.

J Agric Food Chem. 2011 Oct 26;59(20):11234-7.2011PMID 21923188

-

--PMID 10442764

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.113046+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCTTC"
}