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PEPDIA-INT-017934

Silver

Sinapultide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

KLLLLKLLLLKLLLLKLLLLK

Indexed sequence21 aa

1KLLLLKLLLLKLLLLKLLLLK

Length

Molecular weight

2469.45 Da

Formula

C126H238N26O22

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic16

Membrane affinity proxy

Polar0

Solubility proxy

Charged5

Net charge proxy +5

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

2469.3984 Da

Molecular formula

C126H238N26O22

Theoretical pI

10.6025

Net charge at pH 7

4.7551

GRAVY

1.9667

Instability index

-22.819

Aromaticity

Topological polar surface area

775.42 Å²

cLogP

6.4769

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

KLLLLKLLLLKLLLLKLLLLK

HELM 2.0

validated simple linear

PEPTIDE1{K.L.L.L.L.K.L.L.L.L.K.L.L.L.L.K.L.L.L.L.K}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(N)CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-017934,
  title = {Sinapultide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-017934},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Sinapultide. (2026). PepDiana record PEPDIA-INT-017934. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-017934

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (4 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P017934_ACT_peptherdia_0000	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	10peptherdia / linked
CTPDB_P017934_ACT_thpdb_0001	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1146_10669_rec0thpdb / unavailable
CTPDB_P017934_ACT_thpdb_0002	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1146_10670_rec1thpdb / unavailable
CTPDB_P017934_ACT_thpdb_0003	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1146_10671_rec2thpdb / unavailable

Provenance

Source database records (4)

peptherdia

Raw sequence

KLLLLKLLLLKLLLLKLLLLK

thpdb

Th1146_10669_rec0

Raw sequence

KLLLLKLLLLKLLLLKLLLLK

thpdb

Th1146_10670_rec1

Raw sequence

KLLLLKLLLLKLLLLKLLLLK

thpdb

Th1146_10671_rec2

Raw sequence

KLLLLKLLLLKLLLLKLLLLK

Citation trail

Literature (1 records)

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB11332", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB11332)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021746s000lbl.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021746s000lbl.pdf)"}, {"text": "ncats.io", "url": "https://drugs.ncats.io/drug/040X3AX99T", "markdown": "[ncats.io](https://drugs.ncats.io/drug/040X3AX99T)"}]

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB11332", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB11332)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021746s000lbl.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021746s000lbl.pdf)"}, {"text": "ncats.io", "url": "https://drugs.ncats.io/drug/040X3AX99T", "markdown": "[ncats.io](https://drugs.ncats.io/drug/040X3AX99T)"}]

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:21.345173+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "thpdb",
      "assay_method": "Most common adverse reactions associated with the use of lucinactant are endotracheal tube reflux, pallor, endotracheal tube obstruction, and need for dose interruption.",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Most common adverse reactions associated with the use of lucinactant are endotracheal tube reflux, pallor, endotracheal tube obstruction, and need for dose interruption.",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Most common adverse reactions associated with the use of lucinactant are endotracheal tube reflux, pallor, endotracheal tube obstruction, and need for dose interruption.",
      "toxicity_type": "Toxicity"
    }
  ]
}

Source metadata

[
  {
    "source_db": "peptherdia",
    "organism_name": "Unknown"
  },
  {
    "source_db": "thpdb",
    "organism_name": "Unknown"
  }
]

Clinical trials

[
  {
    "status": "Therapeutic",
    "drug_name": "Sinapultide",
    "source_db": "peptherdia",
    "indication": "Prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS.",
    "approval_year": 2012,
    "approval_agency": "FDA",
    "administration_route": "IT"
  }
]

Approved drug annotations

{
  "status": "Therapeutic",
  "drug_name": "Sinapultide",
  "source_db": "peptherdia",
  "indication": "Prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS.",
  "approval_year": 2012,
  "approval_agency": "FDA",
  "administration_route": "IT"
}