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PEPDIA-INT-017410

Gold

Cyclo(Phe-Val), Diketopiperazine (FV)

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

Indexed sequence2 aa

1FV

Length

Molecular weight

264.32 Da

Formula

C14H20N2O3

Structure type

Linear

Synthesis

Non-ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar0

Solubility proxy

Charged0

Net charge proxy +0

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

264.3201 Da

Molecular formula

C14H20N2O3

Theoretical pI

5.525

Net charge at pH 7

-0.2399

GRAVY

3.5

Instability index

Aromaticity

0.5

Topological polar surface area

92.42 Å²

cLogP

0.7818

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HELM 2.0

validated simple linear

PEPTIDE1{F.V}$$$$V2.0

Canonical SMILES

validated

CC(C)C(NC(=O)C(N)Cc1ccccc1)C(=O)O

Isomeric SMILES

validated

CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-017410,
  title = {Cyclo(Phe-Val), Diketopiperazine (FV)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-017410},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Cyclo(Phe-Val), Diketopiperazine (FV). (2026). PepDiana record PEPDIA-INT-017410. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-017410

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (15 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P017410_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available in the current structured import	Unknown	Not reported by source	5414ahtpdb / linked
CTPDB_P017410_ACT_dbaasp_0001	Antimicrobial	-	3.89 µM	Plasmodium berghei	Not reported by source	DBAASPS_18900_chain0dbaasp / linked
CTPDB_P017410_ACT_parapep_0002	Antiparasitic	Antiparasitic	3.23 µM	Unknown	Microscopy	1155parapep / linked
CTPDB_P017410_ACT_parapep_0003	Antiparasitic	Antiparasitic	1.0 µM	Unknown	Fluorimetry (fluorescence by hydrolysis of benzyloxycarbonyl-Phe-Arg-7-amino-4-methyl-coumarin measured)	1283parapep / linked
CTPDB_P017410_ACT_parapep_0004	Antiparasitic	Antiparasitic	1.0 µM	Unknown	Fluorimetry (fluorescence by hydrolysis of benzyloxycarbonyl-Phe-Arg-7-amino-4-methyl-coumarin measured)	1284parapep / linked
CTPDB_P017410_ACT_plantpepdb_0005	Unknown	Taste	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2407plantpepdb / linked
CTPDB_P017410_ACT_satpdb_0006	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb14132satpdb / linked
CTPDB_P017410_ACT_satpdb_0007	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb14132satpdb / linked
CTPDB_P017410_ACT_satpdb_0008	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb14132satpdb / linked
CTPDB_P017410_ACT_satpdb_0009	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb14132satpdb / linked
CTPDB_P017410_ACT_satpdb_0010	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb14132satpdb / linked
CTPDB_P017410_ACT_satpdb_0011	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb14132satpdb / linked
CTPDB_P017410_ACT_satpdb_0012	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb21500satpdb / linked
CTPDB_P017410_ACT_satpdb_0013	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb21500satpdb / linked
CTPDB_P017410_ACT_satpdb_0014	Metabolic/Cardiovascular	Antihypertensive	Not available in the current structured import	Unknown	Not reported by source	satpdb23250satpdb / linked

Provenance

Source database records (9)

ahtpdb

5414

Raw sequence

dbaasp

DBAASPS_18900_chain0

Raw sequence

parapep

1155

Raw sequence

parapep

1283

Raw sequence

parapep

1284

Raw sequence

plantpepdb

PPepDB_2407

Raw sequence

satpdb

satpdb14132

Raw sequence

satpdb

satpdb21500

Raw sequence

satpdb

satpdb23250

Raw sequence

Citation trail

Literature (4 records)

Quantitative structure-activity relationship study of bitter di- and tri-peptides including relationship with angiotensin I-converting enzyme inhibitory activity.

Wu J1, Aluko RE.

J Pept Sci. 2007 Jan;13(1):63-9.2007PMID 17117396

Linear and cyclic dipeptides with antimalarial activity.

Pérez-Picaso L, Olivo HF, Argotte-Ramos R, Rodríguez-Gutiérrez M, Rios MY

Bioorg Med Chem Lett2012PMID 23084276

Linear and cyclic dipeptides with antimalarial activity.

Pérez-Picaso L, Olivo HF, Argotte-Ramos R, Rodríguez-Gutiérrez M, Rios MY

Bioorg Med Chem Lett2012PMID 17190466

-

--PMID 8807047

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.254051+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CC"
}