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PEPDIA-INT-017213

Gold

Venom protein 13a, Polybia-MP-II

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

INWLKLGKMVIDAL

Indexed sequence14 aa

1INWLKLGKMVIDAL

Length

Molecular weight

1614.04 Da

Formula

C76H128N18O18S

Structure type

Linear

Synthesis

Ribosomal

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic9

Membrane affinity proxy

Polar1

Solubility proxy

Charged3

Net charge proxy +1

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1614.004 Da

Molecular formula

C76H128N18O18S

Theoretical pI

8.5909

Net charge at pH 7

0.7592

GRAVY

0.8714

Instability index

15.7857

Aromaticity

0.0714

Topological polar surface area

589.84 Å²

cLogP

-0.6763

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

INWLKLGKMVIDAL

HELM 2.0

validated simple linear

PEPTIDE1{I.N.W.L.K.L.G.K.M.V.I.D.A.L}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(N)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCSC)C(=O)NC(C(=O)NC(C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)O)C(C)CC)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-017213,
  title = {Venom protein 13a, Polybia-MP-II},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-017213},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Venom protein 13a, Polybia-MP-II. (2026). PepDiana record PEPDIA-INT-017213. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-017213

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (55 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P017213_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP01640apd / linked
CTPDB_P017213_ACT_apd_0001	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP01640apd / linked
CTPDB_P017213_ACT_apd_0003	Bioregulatory	Chemotactic	Not available in the current structured import	Unknown	Not reported by source	AP01640apd / linked
CTPDB_P017213_ACT_apd_0004	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	AP01640apd / linked
CTPDB_P017213_ACT_apd_0005	Antimicrobial	Anti-Biofilm	Not available in the current structured import	Unknown	Not reported by source	AP01640apd / linked
CTPDB_P017213_ACT_camp_0008	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ10783camp / linked
CTPDB_P017213_ACT_camp_0009	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ10783camp / linked
CTPDB_P017213_ACT_camp_0006	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9296camp / linked
CTPDB_P017213_ACT_camp_0007	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9296camp / linked
CTPDB_P017213_ACT_dbaasp_0010	Antimicrobial	-	8 µg/ml	Escherichia coli CCT 1457	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0011	Antimicrobial	-	62 µg/ml	Pseudomonas aeruginosa ATCC 15442	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0012	Antimicrobial	-	4 µg/ml	Staphylococcus aureus CCT 2580	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0013	Antimicrobial	-	8 µg/ml	Bacillus cereus ATCC 11778	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0014	Antimicrobial	-	12.5 µM	Mycobacterium abscessus subsp. massiliense GO06	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0015	Antimicrobial	-	1.83 µM	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0016	Antimicrobial	-	2.90 µM	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0017	Antimicrobial	-	12.9 µM	Candida albicans SC5314	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0018	Antimicrobial	-	15.3 µM	Candida albicans SC5314	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0019	Antimicrobial	-	11.0 µM	Cryptococcus neoformans var. grubii H99	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0020	Antimicrobial	-	22.7 µM	Cryptococcus neoformans var. grubii H99	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0021	Antimicrobial	-	4 µM	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0022	Antimicrobial	-	4 µM	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0023	Antimicrobial	-	4 µM	Staphylococcus epidermidis ATCC 12228	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0024	Antimicrobial	-	8 µM	Staphylococcus epidermidis ATCC 12228	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0025	Antimicrobial	-	8 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0026	Antimicrobial	-	8 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0027	Antimicrobial	-	8 µM	Escherichia coli ATCC 43827	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0028	Antimicrobial	-	8 µM	Escherichia coli ATCC 43827	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0029	Antimicrobial	-	8 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0030	Antimicrobial	-	16 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0031	Antimicrobial	-	4 µM	Klebsiella pneumoniae ATCC 700603	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0032	Antimicrobial	-	8 µM	Klebsiella pneumoniae ATCC 700603	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0033	Antimicrobial	-	16 µM	Cronobacter sakazakii ATCC 29544	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0034	Antimicrobial	-	32 µM	Cronobacter sakazakii ATCC 29544	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0035	Antimicrobial	-	8 µM	Candida glabrata ATCC 2001	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0036	Antimicrobial	-	8 µM	Candida glabrata ATCC 2001	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0037	Antimicrobial	-	16 µM	Candida albicans ATCC 14053	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0038	Antimicrobial	-	16 µM	Candida albicans ATCC 14053	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0039	Antimicrobial	-	2 µM	Candida tropicalis ATCC 750	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0040	Antimicrobial	-	8 µM	Candida tropicalis ATCC 750	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0041	Antimicrobial	-	8 µM	Candida krusei ATCC 6258	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0042	Antimicrobial	-	8 µM	Candida krusei ATCC 6258	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0043	Antimicrobial	-	16 µM	Candida parapsilosis ATCC 22019	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dbaasp_0044	Antimicrobial	-	16 µM	Candida parapsilosis ATCC 22019	Not reported by source	DBAASPS_3553_chain0dbaasp / linked
CTPDB_P017213_ACT_dramp_0045	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP18404dramp / linked
CTPDB_P017213_ACT_dramp_0046	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP18404dramp / linked
CTPDB_P017213_ACT_dramp_0047	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP18404dramp / linked
CTPDB_P017213_ACT_dramp_0048	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP18404dramp / linked
CTPDB_P017213_ACT_dramp_0049	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP18404dramp / linked
CTPDB_P017213_ACT_hemolytik_0050	Toxicity	Hemolytic	50.0 µM	Erythrocytes	Not reported by source	1467hemolytik / linked
CTPDB_P017213_ACT_hemolytik_0051	Toxicity	Hemolytic	Not available in the current structured import	Erythrocytes	Not reported by source	1596hemolytik / linked
CTPDB_P017213_ACT_satpdb_0052	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb13782satpdb / linked
CTPDB_P017213_ACT_satpdb_0053	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb13782satpdb / linked
CTPDB_P017213_ACT_satpdb_0054	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb13782satpdb / linked
CTPDB_P017213_ACT_satpdb_0055	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb16059satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003700 View all experimental records

Provenance

Source database records (9)

apd

AP01640

Raw sequence

INWLKLGKMVIDAL

camp

CAMPSQ9296

Raw sequence

INWLKLGKMVIDAL

camp

CAMPSQ10783

Raw sequence

INWLKLGKMVIDAL

dbaasp

DBAASPS_3553_chain0

Raw sequence

INWLKLGKMVIDAL

dramp

DRAMP18404

Raw sequence

INWLKLGKMVIDAL

hemolytik

1467

Raw sequence

INWLKLGKMVIDAL

hemolytik

1596

Raw sequence

INWLKLGKMVIDAL

satpdb

satpdb13782

Raw sequence

INWLKLGKMVIDAL

satpdb

satpdb16059

Raw sequence

INWLKLGKMVIDAL

Citation trail

Literature (6 records)

Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista

de Souza BM, da Silva AV, Resende VM, Arcuri HA, Dos Santos Cabrera MP, Ruggiero Neto J, Palma MS.2009

Peptides2009PMID 19463874

-

--PMID 28108242

-

--PMID 30974767

Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista.

de Souza BM, da Silva AV, Resende VM, Arcuri HA, dos Santos Cabrera MP, Ruggiero Neto J, Palma MS

Peptides2009PMID 34825276

-

--PMID 20195659

-

--PMID 15150833

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.604459+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Rat polymorphonucleated leukocytes "
    },
    {
      "unit": "µM",
      "value": "24.18",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    },
    {
      "unit": "µM",
      "value": "58.12",
      "source_db": "dbaasp",
      "assay_method": "90% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    },
    {
      "unit": "µM",
      "value": "48.47",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "32",
      "source_db": "dbaasp",
      "assay_method": "100% Cytotoxicity",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Mouse fibroblasts NIH 3T3"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSSSSSSCSSSCC"
}