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PEPDIA-INT-015343

Gold

Temporin-GHa

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

FLQHIIGALGHLF

Indexed sequence13 aa

1FLQHIIGALGHLF

Length

Molecular weight

1465.77 Da

Formula

C72H108N18O15

Structure type

Linear

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic8

Membrane affinity proxy

Polar1

Solubility proxy

Charged2

Net charge proxy +2

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1465.7392 Da

Molecular formula

C72H108N18O15

Theoretical pI

6.9177

Net charge at pH 7

-0.0655

GRAVY

1.3154

Instability index

61.5769

Aromaticity

0.1538

Topological polar surface area

512.97 Å²

cLogP

-0.5884

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

FLQHIIGALGHLF

HELM 2.0

validated simple linear

PEPTIDE1{F.L.Q.H.I.I.G.A.L.G.H.L.F}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(N)Cc1ccccc1)C(=O)NC(C(=O)NCC(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(Cc1c[nH]cn1)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)O)C(C)CC

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-015343,
  title = {Temporin-GHa},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-015343},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Temporin-GHa. (2026). PepDiana record PEPDIA-INT-015343. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-015343

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (37 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P015343_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP02967apd / linked
CTPDB_P015343_ACT_apd_0001	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP02967apd / linked
CTPDB_P015343_ACT_apd_0004	Antimicrobial	Anti-Biofilm	Not available in the current structured import	Unknown	Not reported by source	AP02967apd / linked
CTPDB_P015343_ACT_camp_0005	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ23004camp / linked
CTPDB_P015343_ACT_camp_0006	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ23004camp / linked
CTPDB_P015343_ACT_camp_0007	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ23004camp / linked
CTPDB_P015343_ACT_dbaasp_0008	Antimicrobial	-	26.6 µM	Staphylococcus aureus ATCC 43300	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0009	Antimicrobial	-	6.8 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0010	Antimicrobial	-	106.8 µM	Bacillus subtilis ATCC 6633	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0011	Antimicrobial	-	26.6 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0012	Antimicrobial	-	53.2 µM	Escherichia coli	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0013	Antimicrobial	-	13.3 µM	Escherichia coli D31	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0014	Antimicrobial	-	26.6 µM	Vibrio alginolyticus	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0015	Antimicrobial	-	106.8 µM	Pseudomonas aeruginosa ATCC 15442	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0016	Antimicrobial	-	26.6 µM	Candida albicans ATCC 10231	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0017	Antimicrobial	-	12.5 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0018	Antimicrobial	-	25 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0019	Antimicrobial	-	25 µM	Streptococcus mutans ATCC 25175	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0020	Antimicrobial	-	50 µM	Streptococcus mutans ATCC 25175	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0021	Antimicrobial	-	>100 µM	Bacillus subtilis ATCC 6633	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0022	Antimicrobial	-	>100 µM	Bacillus subtilis ATCC 6633	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0023	Antimicrobial	-	100 µM	Staphylococcus aureus ATCC 43300	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0024	Antimicrobial	-	>100 µM	Staphylococcus aureus ATCC 43300	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0025	Antimicrobial	-	>100 µM	Staphylococcus aureus MR	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0026	Antimicrobial	-	>100 µM	Staphylococcus aureus MR	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0027	Antimicrobial	-	25 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0028	Antimicrobial	-	50 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0029	Antimicrobial	-	>100 µM	Escherichia coli D31	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0030	Antimicrobial	-	>100 µM	Escherichia coli D31	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0031	Antimicrobial	-	>100 µM	Pseudomonas aeruginosa PAO1	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0032	Antimicrobial	-	>100 µM	Pseudomonas aeruginosa PAO1	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0033	Antimicrobial	-	>100 µM	Pseudomonas aeruginosa ATCC 15442	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0034	Antimicrobial	-	>100 µM	Pseudomonas aeruginosa ATCC 15442	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0035	Antimicrobial	-	50 µM	Candida albicans ATCC 10231	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dbaasp_0036	Antimicrobial	-	>100 µM	Candida albicans ATCC 10231	Not reported by source	DBAASPS_10244_chain0dbaasp / linked
CTPDB_P015343_ACT_dramp_0037	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP29928dramp / linked
CTPDB_P015343_ACT_dramp_0038	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP29928dramp / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003522 View all experimental records

Provenance

Source database records (4)

apd

AP02967

Raw sequence

FLQHIIGALGHLF

camp

CAMPSQ23004

Raw sequence

FLQHIIGALGHLF

dbaasp

DBAASPS_10244_chain0

Raw sequence

FLQHIIGALGHLF

dramp

DRAMP29928

Raw sequence

FLQHIIGALGHLF

Citation trail

Literature (2 records)

Molecular cloning and characterization of antimicrobial peptides from skin of Hylarana guentheri.

Dong Z, Luo W, Zhong H, Wang M, Song Y, Deng S, Zhang Y.2017, China, Asia

Acta Biochim Biophys Sin (Shanghai)2017PMID 28338958

-

--PMID 31752079

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.609722+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "20",
      "source_db": "dbaasp",
      "assay_method": "10% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "115",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  }
]