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PEPDIA-INT-014824

Silver

Dasiglucagon

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

HSQGTFTSDYSKYLDXARAEEFVKWLEST

Indexed sequence29 aa

1HSQGTFTSDYSKYLDXARAEEFVKWLEST

Length

Molecular weight

Formula

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic10

Membrane affinity proxy

Polar8

Solubility proxy

Charged9

Net charge proxy -1

Aromatic6

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

not calculated nonstandard sequence

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

Not calculated

Molecular formula

Not calculated

Theoretical pI

Not calculated

Net charge at pH 7

Not calculated

GRAVY

Not calculated

Instability index

Not calculated

Aromaticity

Not calculated

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

not available nonstandard sequence

Not calculated for this record

HELM 2.0

not available nonstandard sequence

Not calculated for this record

Canonical SMILES

not available nonstandard sequence

Not calculated for this record

Isomeric SMILES

not available nonstandard sequence

Not calculated for this record

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-014824,
  title = {Dasiglucagon},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-014824},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Dasiglucagon. (2026). PepDiana record PEPDIA-INT-014824. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-014824

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (8 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P014824_ACT_peptherdia_0000	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	109peptherdia / linked
CTPDB_P014824_ACT_thpdb_0001	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1625_15769_rec0thpdb / unavailable
CTPDB_P014824_ACT_thpdb_0002	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1625_15770_rec1thpdb / unavailable
CTPDB_P014824_ACT_thpdb_0003	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1625_15771_rec2thpdb / unavailable
CTPDB_P014824_ACT_thpdb_0004	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1625_15772_rec3thpdb / unavailable
CTPDB_P014824_ACT_thpdb_0005	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1625_15773_rec4thpdb / unavailable
CTPDB_P014824_ACT_thpdb_0006	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1625_15774_rec5thpdb / unavailable
CTPDB_P014824_ACT_thpdb_0007	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1625_15775_rec6thpdb / unavailable

Provenance

Source database records (8)

peptherdia

109

Raw sequence

HSQGTFTSDYSKYLDXARAEEFVKWLEST

thpdb

Th1625_15769_rec0

Raw sequence

HSQGTFTSDYSKYLDXARAEEFVKWLEST

thpdb

Th1625_15770_rec1

Raw sequence

HSQGTFTSDYSKYLDXARAEEFVKWLEST

thpdb

Th1625_15771_rec2

Raw sequence

HSQGTFTSDYSKYLDXARAEEFVKWLEST

thpdb

Th1625_15772_rec3

Raw sequence

HSQGTFTSDYSKYLDXARAEEFVKWLEST

thpdb

Th1625_15773_rec4

Raw sequence

HSQGTFTSDYSKYLDXARAEEFVKWLEST

thpdb

Th1625_15774_rec5

Raw sequence

HSQGTFTSDYSKYLDXARAEEFVKWLEST

thpdb

Th1625_15775_rec6

Raw sequence

HSQGTFTSDYSKYLDXARAEEFVKWLEST

Citation trail

Literature (1 records)

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB15226 ", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB15226 )"}, {"text": "nih.gov", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/Dasiglucagon#section=Isomeric-SMILES", "markdown": "[nih.gov](https://pubchem.ncbi.nlm.nih.gov/compound/Dasiglucagon#section=Isomeric-SMILES)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varApplNo=214231 ", "markdown"

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB15226 ", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB15226 )"}, {"text": "nih.gov", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/Dasiglucagon#section=Isomeric-SMILES", "markdown": "[nih.gov](https://pubchem.ncbi.nlm.nih.gov/compound/Dasiglucagon#section=Isomeric-SMILES)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varApplNo=214231 ", "markdown"

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:21.345173+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "thpdb",
      "assay_method": "Overdose may be characterized by nausea, vomiting, inhibition of gastrointestinal tract motility, increased blood pressure, and elevated heart rate. In case of a suspected overdose, serum potassium ma",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Overdose may be characterized by nausea, vomiting, inhibition of gastrointestinal tract motility, increased blood pressure, and elevated heart rate. In case of a suspected overdose, serum potassium ma",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Overdose may be characterized by nausea, vomiting, inhibition of gastrointestinal tract motility, increased blood pressure, and elevated heart rate. In case of a suspected overdose, serum potassium ma",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Overdose may be characterized by nausea, vomiting, inhibition of gastrointestinal tract motility, increased blood pressure, and elevated heart rate. In case of a suspected overdose, serum potassium ma",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Overdose may be characterized by nausea, vomiting, inhibition of gastrointestinal tract motility, increased blood pressure, and elevated heart rate. In case of a suspected overdose, serum potassium ma",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Overdose may be characterized by nausea, vomiting, inhibition of gastrointestinal tract motility, increased blood pressure, and elevated heart rate. In case of a suspected overdose, serum potassium ma",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Overdose may be characterized by nausea, vomiting, inhibition of gastrointestinal tract motility, increased blood pressure, and elevated heart rate. In case of a suspected overdose, serum potassium ma",
      "toxicity_type": "Toxicity"
    }
  ]
}

Source metadata

[
  {
    "source_db": "peptherdia",
    "organism_name": "Unknown"
  },
  {
    "source_db": "thpdb",
    "organism_name": "Unknown"
  }
]

Clinical trials

[
  {
    "status": "Therapeutic (orphan)",
    "drug_name": "Dasiglucagon",
    "source_db": "peptherdia",
    "indication": "Glucagon analog used to treat severe hypoglycemia in pediatric and adult patients with diabetes.",
    "approval_year": 2017,
    "approval_agency": "FDA",
    "administration_route": "SC"
  }
]

Approved drug annotations

{
  "status": "Therapeutic (orphan)",
  "drug_name": "Dasiglucagon",
  "source_db": "peptherdia",
  "indication": "Glucagon analog used to treat severe hypoglycemia in pediatric and adult patients with diabetes.",
  "approval_year": 2017,
  "approval_agency": "FDA",
  "administration_route": "SC"
}