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PEPDIA-INT-011127

Gold

Angiotensin I-converting enzyme inhibitor 2

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

YYAPFDGIL

Indexed sequence9 aa

1YYAPFDGIL

Length

Molecular weight

1058.20 Da

Formula

C53H71N9O14

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic6

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy -1

Aromatic3

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1058.1825 Da

Molecular formula

C53H71N9O14

Theoretical pI

4.05

Net charge at pH 7

-1.2408

GRAVY

0.5333

Instability index

117.3889

Aromaticity

0.3333

Topological polar surface area

365.09 Å²

cLogP

0.1404

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

YYAPFDGIL

HELM 2.0

validated simple linear

PEPTIDE1{Y.Y.A.P.F.D.G.I.L}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(Cc1ccccc1)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(CC(C)C)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-011127,
  title = {Angiotensin I-converting enzyme inhibitor 2},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-011127},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Angiotensin I-converting enzyme inhibitor 2. (2026). PepDiana record PEPDIA-INT-011127. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-011127

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (6 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P011127_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	83.0 µM	Unknown	Not reported by source	1908ahtpdb / linked
CTPDB_P011127_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	83.18 µM	Unknown	Not reported by source	2441ahtpdb / linked
CTPDB_P011127_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4615ahtpdb / linked
CTPDB_P011127_ACT_plantpepdb_0003	Enzyme Inhibitor	General Enzyme Inhibitor	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2893plantpepdb / linked
CTPDB_P011127_ACT_plantpepdb_0004	Neuroactive/Ion Channel	Neuropeptide	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2893plantpepdb / linked
CTPDB_P011127_ACT_satpdb_0005	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb18554satpdb / linked

Provenance

Source database records (6)

ahtpdb

4615

Raw sequence

YYAPFDGIL

ahtpdb

2441

Raw sequence

YYAPFDGIL

ahtpdb

1908

Raw sequence

YYAPFDGIL

fermfoodb

FermFooDB_Wine_FMDB1018

Raw sequence

YYAPFDGIL

plantpepdb

PPepDB_2893

Raw sequence

YYAPFDGIL

satpdb

satpdb18554

Raw sequence

YYAPFDGIL

Citation trail

Literature (3 records)

QSAR study on angiotensin-converting enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors.

Wang X1, Wang J, Lin Y, Ding Y, Wang Y, Cheng X, Lin Z.

J Mol Model. 2011 Jul;17(7):1599-606.2011PMID 20941517

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

Vegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities.

M C García, P Puchalska, C Esteve, M L Marina

Talanta 03/2013; 106C:328-349.2013PMID 23598136

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "fermfoodb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSTTTTTC"
}