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PEPDIA-INT-010628

Gold

DnsLK9(2.0)

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

KLKLKLKLK

Indexed sequence9 aa

1KLKLKLKLK

Length

Molecular weight

1111.53 Da

Formula

C54H106N14O10

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar0

Solubility proxy

Charged5

Net charge proxy +5

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1111.5072 Da

Molecular formula

C54H106N14O10

Theoretical pI

10.6025

Net charge at pH 7

4.7551

GRAVY

-0.4778

Instability index

-66.5778

Aromaticity

Topological polar surface area

426.22 Å²

cLogP

0.1061

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

KLKLKLKLK

HELM 2.0

validated simple linear

PEPTIDE1{K.L.K.L.K.L.K.L.K}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(N)CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-010628,
  title = {DnsLK9(2.0)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-010628},
  note = {Accessed from local PepDiana development build}
}

APA-style note

DnsLK9(2.0). (2026). PepDiana record PEPDIA-INT-010628. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-010628

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (13 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P010628_ACT_dbaasp_0006	Antimicrobial	-	32 µg/ml	Escherichia coli DSM 1116	Not reported by source	DBAASPS_19687_chain0dbaasp / linked
CTPDB_P010628_ACT_dbaasp_0007	Antimicrobial	-	8 µg/ml	Franconibacter helveticus DSM 18390	Not reported by source	DBAASPS_19687_chain0dbaasp / linked
CTPDB_P010628_ACT_dbaasp_0008	Antimicrobial	-	16 µg/ml	Bacillus subtilis DSM 347	Not reported by source	DBAASPS_19687_chain0dbaasp / linked
CTPDB_P010628_ACT_dbaasp_0009	Antimicrobial	-	2 µg/ml	Staphylococcus xylosus DSM 20287	Not reported by source	DBAASPS_19687_chain0dbaasp / linked
CTPDB_P010628_ACT_dbaasp_0000	Antimicrobial	-	6.25 µM	Acholeplasma laidlawii A-EF22	Not reported by source	DBAASPS_2061_chain0dbaasp / linked
CTPDB_P010628_ACT_dbaasp_0001	Antimicrobial	-	6.25 µM	Mycoplasma gallisepticum S6	Not reported by source	DBAASPS_2061_chain0dbaasp / linked
CTPDB_P010628_ACT_dbaasp_0002	Antimicrobial	-	NA	Mycoplasma mycoides ssp. mycoides SC KH3J	Not reported by source	DBAASPS_2061_chain0dbaasp / linked
CTPDB_P010628_ACT_dbaasp_0003	Antimicrobial	-	50 µM	Spiroplasma citri R8A2	Not reported by source	DBAASPS_2061_chain0dbaasp / linked
CTPDB_P010628_ACT_dbaasp_0004	Antimicrobial	-	100 µM	Spiroplasma floricola BNR 1	Not reported by source	DBAASPS_2061_chain0dbaasp / linked
CTPDB_P010628_ACT_dbaasp_0005	Antimicrobial	-	50 µM	Spiroplasma melliferum BC3	Not reported by source	DBAASPS_2061_chain0dbaasp / linked
CTPDB_P010628_ACT_hemolytik_0010	Toxicity	Hemolytic	10.0 µM	Erythrocytes	Not reported by source	2009hemolytik / linked
CTPDB_P010628_ACT_satpdb_0011	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb29073satpdb / linked
CTPDB_P010628_ACT_satpdb_0012	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb29073satpdb / linked

Provenance

Source database records (4)

dbaasp

DBAASPS_2061_chain0

Raw sequence

KLKLKLKLK

dbaasp

DBAASPS_19687_chain0

Raw sequence

KLKLKLKLK

hemolytik

2009

Raw sequence

KLKLKLKLK

satpdb

satpdb29073

Raw sequence

KLKLKLKLK

Citation trail

Literature (3 records)

The antibiotic activity of cationic linear amphipathic peptides: lessons from the action of leucine/lysine copolymers on bacteria of the class Mollicutes.

Béven L, Castano S, Dufourcq J, Wieslander A, Wróblewski H

Eur J Biochem2003PMID 12752440

Membranolytic Mechanism of Amphiphilic Antimicrobial β-Stranded [KL]n Peptides

Schweigardt F, Strandberg E, Wadhwani P, Reichert J, Bürck J, Cravo HLP, Burger L, Ulrich AS

Biomedicines2022PMID 36140173

-

--PMID 10631295

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:17.756235+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "256",
      "source_db": "dbaasp",
      "assay_method": "20% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": ">256",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]