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PEPDIA-INT-010003

Gold

Cyclo(Phe-Gly)

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

Indexed sequence2 aa

1FG

Length

Molecular weight

Formula

Structure type

Cyclic

Synthesis

Non-ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar0

Solubility proxy

Charged0

Net charge proxy +0

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

partial sequence only structural context

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

222.2404 Da

Molecular formula

Not calculated

Theoretical pI

5.525

Net charge at pH 7

-0.2399

GRAVY

1.2

Instability index

Aromaticity

0.5

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

not generated modification context

Not calculated for this record

HELM 2.0

not generated modification context

Not calculated for this record

Canonical SMILES

not generated modification context

Not calculated for this record

Isomeric SMILES

not generated modification context

Not calculated for this record

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-010003,
  title = {Cyclo(Phe-Gly)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-010003},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Cyclo(Phe-Gly). (2026). PepDiana record PEPDIA-INT-010003. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-010003

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (32 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P010003_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	20.0 mM	Unknown	Not reported by source	1483ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0004	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3058ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0005	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3144ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0006	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3238ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0007	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3479ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0008	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3809ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0009	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3876ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0010	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	3907ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4415ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4515ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	4674ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0011	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	5412ahtpdb / linked
CTPDB_P010003_ACT_ahtpdb_0012	Metabolic/Cardiovascular	ACE Inhibitor	3700.0 µM	Unknown	Not reported by source	6591ahtpdb / linked
CTPDB_P010003_ACT_dbaasp_0013	Antimicrobial	-	4.26 µM	Plasmodium berghei	Not reported by source	DBAASPS_18978_chain0dbaasp / linked
CTPDB_P010003_ACT_dbaasp_0014	Antimicrobial	-	>100 µg/ml	Botrytis cinerea	Not reported by source	DBAASPS_18978_chain0dbaasp / linked
CTPDB_P010003_ACT_dbaasp_0015	Antimicrobial	-	>100 µg/ml	Alternaria solani	Not reported by source	DBAASPS_18978_chain0dbaasp / linked
CTPDB_P010003_ACT_dbaasp_0016	Antimicrobial	-	>100 µg/ml	Alternaria alternata	Not reported by source	DBAASPS_18978_chain0dbaasp / linked
CTPDB_P010003_ACT_dbaasp_0017	Antimicrobial	-	>100 µg/ml	Colletotrichum gloeosporioides	Not reported by source	DBAASPS_18978_chain0dbaasp / linked
CTPDB_P010003_ACT_dbaasp_0018	Antimicrobial	-	>100 µg/ml	Fusarium solani	Not reported by source	DBAASPS_18978_chain0dbaasp / linked
CTPDB_P010003_ACT_dbaasp_0019	Antimicrobial	-	>100 µg/ml	Fusarium oxysporum	Not reported by source	DBAASPS_18978_chain0dbaasp / linked
CTPDB_P010003_ACT_dbaasp_0020	Antimicrobial	-	>100 µg/ml	Fusarium graminearum	Not reported by source	DBAASPS_18978_chain0dbaasp / linked
CTPDB_P010003_ACT_dramp_0021	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP24288dramp / linked
CTPDB_P010003_ACT_parapep_0022	Antiparasitic	Antiparasitic	4.26 µM	Unknown	Microscopy	1170parapep / linked
CTPDB_P010003_ACT_plantpepdb_0023	Unknown	Taste	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2903plantpepdb / linked
CTPDB_P010003_ACT_plantpepdb_0024	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	PPepDB_2903plantpepdb / linked
CTPDB_P010003_ACT_satpdb_0025	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb13141satpdb / linked
CTPDB_P010003_ACT_satpdb_0026	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb13141satpdb / linked
CTPDB_P010003_ACT_satpdb_0027	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb13141satpdb / linked
CTPDB_P010003_ACT_satpdb_0028	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb13141satpdb / linked
CTPDB_P010003_ACT_satpdb_0029	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb13141satpdb / linked
CTPDB_P010003_ACT_satpdb_0030	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb13141satpdb / linked
CTPDB_P010003_ACT_satpdb_0031	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb14084satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003492 View all experimental records

Provenance

Source database records (19)

ahtpdb

4415

Raw sequence

ahtpdb

4515

Raw sequence

ahtpdb

4674

Raw sequence

ahtpdb

1483

Raw sequence

ahtpdb

6591

Raw sequence

ahtpdb

5412

Raw sequence

ahtpdb

3058

Raw sequence

ahtpdb

3144

Raw sequence

ahtpdb

3238

Raw sequence

ahtpdb

3479

Raw sequence

ahtpdb

3809

Raw sequence

ahtpdb

3876

Raw sequence

ahtpdb

3907

Raw sequence

dbaasp

DBAASPS_18978_chain0

Raw sequence

dramp

DRAMP24288

Raw sequence

parapep

1170

Raw sequence

plantpepdb

PPepDB_2903

Raw sequence

satpdb

satpdb13141

Raw sequence

satpdb

satpdb14084

Raw sequence

Citation trail

Literature (14 records)

Modelling relationship between angiotensin-(I)-converting enzyme inhibition and the bitter taste of peptides

Are Hugo Pripp, Ylva Ardö

Food Chemistry - FOOD CHEM 01/2007; 102(3):880-888.2007

QSAR study on angiotensin-converting enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors.

Wang X1, Wang J, Lin Y, Ding Y, Wang Y, Cheng X, Lin Z.

J Mol Model. 2011 Jul;17(7):1599-606.2011PMID 20941517

What are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach.

Zhou P et al.

Food Chem. 2013 Dec 1;141(3):2967-73.2013PMID 23871047

Structural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides.

Wu J1, Aluko RE, Nakai S.

J Agric Food Chem. 2006 Feb 8;54(3):732-8.2006PMID 16448176

Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.

Cheung HS et al.,

J Biol Chem. 1980 Jan 25;255(2):401-7.1980PMID 6243277

Quantitative structure-activity relationship study of bitter di- and tri-peptides including relationship with angiotensin I-converting enzyme inhibitory activity.

Wu J1, Aluko RE.

J Pept Sci. 2007 Jan;13(1):63-9.2007PMID 17117396

Peptides with angiotensin I converting enzyme (ACE) inhibitory activity generated from porcine skeletal muscle proteins by the action of meat-borne Lactobacillus.

Castellano P1, Aristoy MC, Sentandreu MÁ, Vignolo G, Toldrá F.

J Proteomics. 2013 Aug 26;89:183-90.2013PMID 23806758

Animal and Plant Proteins as Precursors of Peptides with ACE Inhibitory Activity – An in silico Strategy of Protein Evaluation

Anna Iwaniak and Jerzy Dziuba

Food Technol. Biotechnol. 47 (4) 441–449 (2009)2009

MOTIFS WITH POTENTIAL PHYSIOLOGICAL ACTIVITY IN FOOD PROTEINS - BIOPEP DATABASE

Iwaniak, Anna; Dziuba, Bartlomiej

Acta Scientiarum Polonorum. Technologia Alimentaria;2009, Vol. 8 Issue 3, p592009

Three-dimensional holograph vector of atomic interaction field (3D-HoVAIF): a novel rotation-translation invariant 3D structure descriptor and its applications to peptides.

Tian F1, Zhou P, Lv F, Song R, Li Z.

J Pept Sci. 2007 Aug;13(8):549-66.2007PMID 17654623

Identification of Bioactive Peptides from Cereal Storage Proteins and Their Potential Role in Prevention of Chronic Diseases

Ariel Cavazos and Elvira Gonzalez de Mejia

Comprehensive Reviews in Food Science and Food Safety Volume 12, Issue 4, pages 364–380, July 20132013

Linear and cyclic dipeptides with antimalarial activity.

Pérez-Picaso L, Olivo HF, Argotte-Ramos R, Rodríguez-Gutiérrez M, Rios MY

Bioorg Med Chem Lett2012PMID 23084276

Linear and cyclic dipeptides with antimalarial activity.

Pérez-Picaso L, Olivo HF, Argotte-Ramos R, Rodríguez-Gutiérrez M, Rios MY

Bioorg Med Chem Lett2012PMID 22409377

Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries

Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies

Cell2018PMID 29307492

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CC"
}