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PEPDIA-INT-008272

Gold

Venom protein 13b, Polybia-MP-III

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

IDWLKLGKMVMDVL

Indexed sequence14 aa

1IDWLKLGKMVMDVL

Length

Molecular weight

1661.11 Da

Formula

C77H129N17O19S2

Structure type

Linear

Synthesis

Ribosomal

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic9

Membrane affinity proxy

Polar0

Solubility proxy

Charged4

Net charge proxy +0

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1661.0803 Da

Molecular formula

C77H129N17O19S2

Theoretical pI

5.9598

Net charge at pH 7

-0.2397

GRAVY

0.8571

Instability index

23.1929

Aromaticity

0.0714

Topological polar surface area

584.05 Å²

cLogP

0.2661

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

IDWLKLGKMVMDVL

HELM 2.0

validated simple linear

PEPTIDE1{I.D.W.L.K.L.G.K.M.V.M.D.V.L}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(N)C(=O)NC(CC(=O)O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCSC)C(=O)NC(C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(C(=O)NC(CC(C)C)C(=O)O)C(C)C)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-008272,
  title = {Venom protein 13b, Polybia-MP-III},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-008272},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Venom protein 13b, Polybia-MP-III. (2026). PepDiana record PEPDIA-INT-008272. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-008272

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (21 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P008272_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP01641apd / linked
CTPDB_P008272_ACT_apd_0001	Bioregulatory	Chemotactic	Not available in the current structured import	Unknown	Not reported by source	AP01641apd / linked
CTPDB_P008272_ACT_apd_0002	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	AP01641apd / linked
CTPDB_P008272_ACT_camp_0003	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3394camp / linked
CTPDB_P008272_ACT_camp_0004	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3394camp / linked
CTPDB_P008272_ACT_dbaasp_0005	Antimicrobial	-	62 µg/ml	Escherichia coli CCT 1457	Not reported by source	DBAASPS_3554_chain0dbaasp / linked
CTPDB_P008272_ACT_dbaasp_0006	Antimicrobial	-	500 µg/ml	Pseudomonas aeruginosa ATCC 15442	Not reported by source	DBAASPS_3554_chain0dbaasp / linked
CTPDB_P008272_ACT_dbaasp_0007	Antimicrobial	-	31 µg/ml	Staphylococcus aureus CCT 2580	Not reported by source	DBAASPS_3554_chain0dbaasp / linked
CTPDB_P008272_ACT_dbaasp_0008	Antimicrobial	-	62 µg/ml	Bacillus cereus ATCC 11778	Not reported by source	DBAASPS_3554_chain0dbaasp / linked
CTPDB_P008272_ACT_dramp_0009	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP04544dramp / linked
CTPDB_P008272_ACT_dramp_0010	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP04544dramp / linked
CTPDB_P008272_ACT_dramp_0011	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP04544dramp / linked
CTPDB_P008272_ACT_dramp_0012	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP04544dramp / linked
CTPDB_P008272_ACT_dramp_0013	Anticancer	Cytotoxic	Not available in the current structured import	Unknown	Not reported by source	DRAMP04544dramp / linked
CTPDB_P008272_ACT_hemolytik_0014	Toxicity	Hemolytic	50.0 µM	Erythrocytes	Not reported by source	1466hemolytik / linked
CTPDB_P008272_ACT_hemolytik_0015	Toxicity	Hemolytic	Not available in the current structured import	Erythrocytes	Not reported by source	1597hemolytik / linked
CTPDB_P008272_ACT_satpdb_0016	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb15037satpdb / linked
CTPDB_P008272_ACT_satpdb_0017	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb15037satpdb / linked
CTPDB_P008272_ACT_satpdb_0018	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb15643satpdb / linked
CTPDB_P008272_ACT_satpdb_0019	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb15643satpdb / linked
CTPDB_P008272_ACT_satpdb_0020	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb15643satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003653 View all experimental records

Provenance

Source database records (8)

apd

AP01641

Raw sequence

IDWLKLGKMVMDVL

camp

CAMPSQ3394

Raw sequence

IDWLKLGKMVMDVL

dbaasp

DBAASPS_3554_chain0

Raw sequence

IDWLKLGKMVMDVL

dramp

DRAMP04544

Raw sequence

IDWLKLGKMVMDVL

hemolytik

1466

Raw sequence

IDWLKLGKMVMDVL

hemolytik

1597

Raw sequence

IDWLKLGKMVMDVL

satpdb

satpdb15037

Raw sequence

IDWLKLGKMVMDVL

satpdb

satpdb15643

Raw sequence

IDWLKLGKMVMDVL

Citation trail

Literature (4 records)

{"reference": "Peptides. 2009 Aug;30(8):1387-95", "title": "Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista", "author": "de Souza BM, da Silva AV, Resende VM, Arcuri HA, Dos Santos Cabrera MP, Ruggiero Neto J, Palma MS.2009"}

{"reference": "Peptides. 2009 Aug;30(8):1387-95", "title": "Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista", "author": "de Souza BM, da Silva AV, Resende VM, Arcuri HA, Dos Santos Cabrera MP, Ruggiero Neto J, Palma MS.2009"}

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.604459+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Rat polymorphonucleated leukocytes "
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCTTTTSSBTTBCC"
}