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PEPDIA-INT-007312

Gold

Kalata B2

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

GLPVCGETCFGGTCNTPGCSCTWPICTRD

Indexed sequence29 aa

1GLPVCGETCFGGTCNTPGCSCTWPICTRD

Length

Molecular weight

Formula

Structure type

Cyclic

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic5

Membrane affinity proxy

Polar13

Solubility proxy

Charged3

Net charge proxy -1

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

partial sequence only structural context

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

2979.3912 Da

Molecular formula

Not calculated

Theoretical pI

4.6693

Net charge at pH 7

-1.2922

GRAVY

0.1138

Instability index

47.2793

Aromaticity

0.069

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

not generated modification context

Not calculated for this record

HELM 2.0

not generated modification context

Not calculated for this record

Canonical SMILES

not generated modification context

Not calculated for this record

Isomeric SMILES

not generated modification context

Not calculated for this record

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-007312,
  title = {Kalata B2},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-007312},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Kalata B2. (2026). PepDiana record PEPDIA-INT-007312. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-007312

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (46 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P007312_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP01049apd / linked
CTPDB_P007312_ACT_apd_0001	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	AP01049apd / linked
CTPDB_P007312_ACT_apd_0002	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP01049apd / linked
CTPDB_P007312_ACT_apd_0003	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	AP01049apd / linked
CTPDB_P007312_ACT_apd_0004	Antimicrobial	Insecticidal	Not available in the current structured import	Unknown	Not reported by source	AP01049apd / linked
CTPDB_P007312_ACT_apd_0005	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	AP01049apd / linked
CTPDB_P007312_ACT_camp_0006	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9469camp / linked
CTPDB_P007312_ACT_camp_0007	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9469camp / linked
CTPDB_P007312_ACT_dbaasp_0008	Antimicrobial	-	160 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0009	Antimicrobial	-	>160 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0010	Antimicrobial	-	>160 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0011	Antimicrobial	-	40 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0012	Antimicrobial	-	80 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0013	Antimicrobial	-	160 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0014	Antimicrobial	-	>160 µM	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0015	Antimicrobial	-	>160 µM	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0016	Antimicrobial	-	>160 µM	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0017	Antimicrobial	-	>160 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0018	Antimicrobial	-	>160 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0019	Antimicrobial	-	>160 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0020	Antimicrobial	-	2.6 µM	Human histiocytic lymphoma U-937/GTB	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0021	Antimicrobial	-	1.59 µM	Haemonchus contortus	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0022	Antimicrobial	-	5.69 µM	Trichostrongylus colubriformis	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0023	Antimicrobial	-	10.3±0.4 µM	Human skin melanoma MM96L	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0024	Antimicrobial	-	7.8±0.7 µM	Human cervical carcinoma HeLa	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dbaasp_0025	Antimicrobial	-	5.2±0.3 µM	Human myelogenous leukemia K562	Not reported by source	DBAASPS_5236_chain0dbaasp / linked
CTPDB_P007312_ACT_dramp_0026	Antimicrobial	Insecticidal	Not available in the current structured import	Unknown	Not reported by source	DRAMP00857dramp / linked
CTPDB_P007312_ACT_parapep_0027	Antiparasitic	Antiparasitic	18.2 µM	Unknown	Motor activity and mortality rate(phalloidin staining)	1876parapep / linked
CTPDB_P007312_ACT_parapep_0028	Antiparasitic	Antiparasitic	15.5 µM	Unknown	Motor activity and mortality rate(phalloidin staining)	1877parapep / linked
CTPDB_P007312_ACT_plantpepdb_0029	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2207plantpepdb / linked
CTPDB_P007312_ACT_plantpepdb_0030	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2207plantpepdb / linked
CTPDB_P007312_ACT_plantpepdb_0031	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2207plantpepdb / linked
CTPDB_P007312_ACT_plantpepdb_0032	Antiparasitic	Nematocide	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2207plantpepdb / linked
CTPDB_P007312_ACT_plantpepdb_0033	Unknown	Molluscicidal	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2207plantpepdb / linked
CTPDB_P007312_ACT_plantpepdb_0034	Unknown	Membrane-Binding	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2207plantpepdb / linked
CTPDB_P007312_ACT_plantpepdb_0035	Antimicrobial	Insecticidal	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2207plantpepdb / linked
CTPDB_P007312_ACT_plantpepdb_0036	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2207plantpepdb / linked
CTPDB_P007312_ACT_plantpepdb_0037	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2207plantpepdb / linked
CTPDB_P007312_ACT_plantpepdb_0038	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2207plantpepdb / linked
CTPDB_P007312_ACT_satpdb_0039	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb10433satpdb / linked
CTPDB_P007312_ACT_satpdb_0040	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb10433satpdb / linked
CTPDB_P007312_ACT_satpdb_0041	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb10433satpdb / linked
CTPDB_P007312_ACT_satpdb_0042	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb10433satpdb / linked
CTPDB_P007312_ACT_satpdb_0043	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb10433satpdb / linked
CTPDB_P007312_ACT_satpdb_0044	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb10433satpdb / linked
CTPDB_P007312_ACT_satpdb_0045	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb26274satpdb / linked

Provenance

Source database records (9)

apd

AP01049

Raw sequence

GLPVCGETCFGGTCNTPGCSCTWPICTRD

camp

CAMPSQ9469

Raw sequence

GLPVCGETCFGGTCNTPGCSCTWPICTRD

dbaasp

DBAASPS_5236_chain0

Raw sequence

GLPVCGETCFGGTCNTPGCSCTWPICTRD

dramp

DRAMP00857

Raw sequence

GLPVCGETCFGGTCNTPGCSCTWPICTRD

parapep

1876

Raw sequence

GLPVCGETCFGGTCNTPGCSCTWPICTRD

parapep

1877

Raw sequence

GLPVCGETCFGGTCNTPGCSCTWPICTRD

plantpepdb

PPepDB_2207

Raw sequence

GLPVCGETCFGGTCNTPGCSCTWPICTRD

satpdb

satpdb10433

Raw sequence

GLPVCGETCFGGTCNTPGCSCTWPICTRD

satpdb

satpdb26274

Raw sequence

GLPVCGETCFGGTCNTPGCSCTWPICTRD

Citation trail

Literature (11 records)

Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif.

Craik DJ, Daly NL, Bond T, Waine C.1999

J Mol Biol1999PMID 10600388

-

--PMID 28669767

Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis.

Plan MR, Rosengren KJ, Sando L, Daly NL, Craik DJ

Biopolymers2010PMID 20564013

Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis.

Plan MR, Rosengren KJ, Sando L, Daly NL, Craik DJ

Biopolymers2010PMID 15654741

Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis.

Plan MR, Rosengren KJ, Sando L, Daly NL, Craik DJ

Biopolymers2010PMID 18618891

Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis.

Plan MR, Rosengren KJ, Sando L, Daly NL, Craik DJ

Biopolymers2010PMID 25099014

Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif.##Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?##The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.##Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis

Craik DJ, Daly NL, Bond T, Waine C.##Jennings CV, Rosengren KJ, Daly NL, Plan M, Stevens J, Scanlon MJ, Waine C, Norman DG, Anderson MA, Craik DJ.##Plan MR, Göransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.##Manuel R Plan, K Johan Rosengren, Lillian Sando, Norelle L Daly, David J Craik

J Mol Biol1999PMID 17534989

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.491115+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "3.3±1.9",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "11.5±0.6",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "1.5±0.1",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human PBMC"
    },
    {
      "unit": "µM",
      "value": "6.4±0.4",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human foreskin fibroblasts (HFF)"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.20564013] HD50=3.3±1.9 μM against Human red blood cells .",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSCCBCSSCTTTSSCCSCTTBCCSSTTC"
}