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PEPDIA-INT-005877

Gold

IK2

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

GIIKKIIKKI

Indexed sequence10 aa

1GIIKKIIKKI

Length

Molecular weight

1153.57 Da

Formula

C56H108N14O11

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic5

Membrane affinity proxy

Polar0

Solubility proxy

Charged4

Net charge proxy +4

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1153.5438 Da

Molecular formula

C56H108N14O11

Theoretical pI

10.4777

Net charge at pH 7

3.7561

GRAVY

0.65

Instability index

-33.45

Aromaticity

Topological polar surface area

429.3 Å²

cLogP

0.1394

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

GIIKKIIKKI

HELM 2.0

validated simple linear

PEPTIDE1{G.I.I.K.K.I.I.K.K.I}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(NC(=O)CN)C(C)CC)C(C)CC)C(C)CC)C(C)CC)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-005877,
  title = {IK2},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-005877},
  note = {Accessed from local PepDiana development build}
}

APA-style note

IK2. (2026). PepDiana record PEPDIA-INT-005877. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-005877

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (23 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P005877_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP04801apd / linked
CTPDB_P005877_ACT_camp_0001	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ20837camp / linked
CTPDB_P005877_ACT_camp_0002	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ20837camp / linked
CTPDB_P005877_ACT_cancerppd_0003	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	2839cancerppd / linked
CTPDB_P005877_ACT_cancerppd_0004	Antimicrobial	-	Not available in the current structured import	Unknown	MTT/MTS assay	2839cancerppd / linked
CTPDB_P005877_ACT_cancerppd_0005	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	2842cancerppd / linked
CTPDB_P005877_ACT_cancerppd_0006	Antimicrobial	-	Not available in the current structured import	Unknown	MTT/MTS assay	2842cancerppd / linked
CTPDB_P005877_ACT_dbaasp_0007	Antimicrobial	-	125±5.6 µM	Escherichia coli DH5alpha	Not reported by source	DBAASPS_4593_chain0dbaasp / linked
CTPDB_P005877_ACT_dbaasp_0008	Antimicrobial	-	30±2.5 µM	Bacillus subtilis 168	Not reported by source	DBAASPS_4593_chain0dbaasp / linked
CTPDB_P005877_ACT_dbaasp_0009	Antimicrobial	-	160±7.6 µM	Human cervical carcinoma HeLa	Not reported by source	DBAASPS_4593_chain0dbaasp / linked
CTPDB_P005877_ACT_dbaasp_0010	Antimicrobial	-	>500 µM	Human promyelocytic leukemia HL-60	Not reported by source	DBAASPS_4593_chain0dbaasp / linked
CTPDB_P005877_ACT_dbaasp_0011	Antimicrobial	-	>128 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_4593_chain0dbaasp / linked
CTPDB_P005877_ACT_dbaasp_0012	Antimicrobial	-	16 µM	Bacillus subtilis ATCC 23857	Not reported by source	DBAASPS_4593_chain0dbaasp / linked
CTPDB_P005877_ACT_dbaasp_0013	Antimicrobial	-	>128 µM	Klebsiella pneumoniae ATCC 700603	Not reported by source	DBAASPS_4593_chain0dbaasp / linked
CTPDB_P005877_ACT_dbaasp_0014	Antimicrobial	-	32 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_4593_chain0dbaasp / linked
CTPDB_P005877_ACT_dbaasp_0015	Antimicrobial	-	64 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_4593_chain0dbaasp / linked
CTPDB_P005877_ACT_dbaasp_0016	Antimicrobial	-	64 µM	Acinetobacter baumannii ATCC 19606	Not reported by source	DBAASPS_4593_chain0dbaasp / linked
CTPDB_P005877_ACT_dramp_0017	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP31833dramp / linked
CTPDB_P005877_ACT_dramp_0018	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP31833dramp / linked
CTPDB_P005877_ACT_hemolytik_0019	Toxicity	Hemolytic	250.0 µM	Erythrocytes	Not reported by source	2965hemolytik / linked
CTPDB_P005877_ACT_satpdb_0020	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb26556satpdb / linked
CTPDB_P005877_ACT_satpdb_0021	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb26556satpdb / linked
CTPDB_P005877_ACT_satpdb_0022	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb26556satpdb / linked

Provenance

Source database records (8)

apd

AP04801

Raw sequence

GIIKKIIKKI

camp

CAMPSQ20837

Raw sequence

GIIKKIIKKI

cancerppd

2839

Raw sequence

GIIKKIIKKI

cancerppd

2842

Raw sequence

GIIKKIIKKI

dbaasp

DBAASPS_4593_chain0

Raw sequence

GIIKKIIKKI

dramp

DRAMP31833

Raw sequence

GIIKKIIKKI

hemolytik

2965

Raw sequence

GIIKKIIKKI

satpdb

satpdb26556

Raw sequence

GIIKKIIKKI

Citation trail

Literature (3 records)

Designed antimicrobial and antitumor peptides with high selectivity.

Hu J, Chen C, Zhang S, Zhao X, Xu H, Zhao X, Lu JR. 2011

Biomacromolecules2011PMID 21955251

-

--PMID 24246647

Designed antimicrobial and antitumor peptides with high selectivity.

Hu J, Chen C, Zhang S, Zhao X, Xu H, Zhao X, Lu JR

Biomacromolecules2011PMID 39141008

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.810082+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": ">256",
      "source_db": "dbaasp",
      "assay_method": "10% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    },
    {
      "unit": "µM",
      "value": ">128",
      "source_db": "dbaasp",
      "assay_method": "IC50",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human embryonic kidney HEK293T cells"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CHHHHHHHHC"
}