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PEPDIA-INT-005850

Gold

Cyclo(Val-Val)

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

Indexed sequence2 aa

1VV

Length

Molecular weight

216.28 Da

Formula

C10H20N2O3

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar0

Solubility proxy

Charged0

Net charge proxy +0

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

216.2773 Da

Molecular formula

C10H20N2O3

Theoretical pI

5.495

Net charge at pH 7

-0.266

GRAVY

4.2

Instability index

Aromaticity

Topological polar surface area

92.42 Å²

cLogP

0.1951

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HELM 2.0

validated simple linear

PEPTIDE1{V.V}$$$$V2.0

Canonical SMILES

validated

CC(C)C(N)C(=O)NC(C(=O)O)C(C)C

Isomeric SMILES

validated

CC(C)[C@H](N)C(=O)N[C@H](C(=O)O)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-005850,
  title = {Cyclo(Val-Val)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-005850},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Cyclo(Val-Val). (2026). PepDiana record PEPDIA-INT-005850. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-005850

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (21 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P005850_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available in the current structured import	Unknown	Not reported by source	3849ahtpdb / linked
CTPDB_P005850_ACT_dbaasp_0001	Antimicrobial	-	2.45 µM	Plasmodium berghei	Not reported by source	DBAASPS_18977_chain0dbaasp / linked
CTPDB_P005850_ACT_dramp_0002	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP35028dramp / linked
CTPDB_P005850_ACT_dramp_0003	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP35028dramp / linked
CTPDB_P005850_ACT_parapep_0004	Antiparasitic	Antiparasitic	2.81 µM	Unknown	Microscopy	1158parapep / linked
CTPDB_P005850_ACT_parapep_0005	Antiparasitic	Antiparasitic	2.45 µM	Unknown	Microscopy	1169parapep / linked
CTPDB_P005850_ACT_plantpepdb_0006	Enzyme Inhibitor	General Enzyme Inhibitor	Not available in the current structured import	Unknown	Not reported by source	PPepDB_2871plantpepdb / linked
CTPDB_P005850_ACT_satpdb_0007	Metabolic/Cardiovascular	Antihypertensive	Not available in the current structured import	Unknown	Not reported by source	satpdb12649satpdb / linked
CTPDB_P005850_ACT_satpdb_0008	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb23063satpdb / linked
CTPDB_P005850_ACT_satpdb_0009	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb23063satpdb / linked
CTPDB_P005850_ACT_satpdb_0010	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb23063satpdb / linked
CTPDB_P005850_ACT_satpdb_0011	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb23063satpdb / linked
CTPDB_P005850_ACT_satpdb_0012	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb23063satpdb / linked
CTPDB_P005850_ACT_satpdb_0013	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb23063satpdb / linked
CTPDB_P005850_ACT_satpdb_0014	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb25129satpdb / linked
CTPDB_P005850_ACT_satpdb_0015	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb25129satpdb / linked
CTPDB_P005850_ACT_satpdb_0016	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb25129satpdb / linked
CTPDB_P005850_ACT_satpdb_0017	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb25129satpdb / linked
CTPDB_P005850_ACT_satpdb_0018	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb25129satpdb / linked
CTPDB_P005850_ACT_satpdb_0019	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb25129satpdb / linked
CTPDB_P005850_ACT_topicalpdb_0020	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	10.0 ng/min; HPLC analysis, tissue hydrolysis, 2 way ANOVA; in vivo	1516topicalpdb / linked

Provenance

Source database records (10)

ahtpdb

3849

Raw sequence

dbaasp

DBAASPS_18977_chain0

Raw sequence

dramp

DRAMP35028

Raw sequence

parapep

1158

Raw sequence

parapep

1169

Raw sequence

plantpepdb

PPepDB_2871

Raw sequence

satpdb

satpdb12649

Raw sequence

satpdb

satpdb23063

Raw sequence

satpdb

satpdb25129

Raw sequence

topicalpdb

1516

Raw sequence

Citation trail

Literature (4 records)

Three-dimensional holograph vector of atomic interaction field (3D-HoVAIF): a novel rotation-translation invariant 3D structure descriptor and its applications to peptides.

Tian F1, Zhou P, Lv F, Song R, Li Z.

J Pept Sci. 2007 Aug;13(8):549-66.2007PMID 17654623

Linear and cyclic dipeptides with antimalarial activity.

Pérez-Picaso L, Olivo HF, Argotte-Ramos R, Rodríguez-Gutiérrez M, Rios MY

Bioorg Med Chem Lett2012PMID 23084276

-

--PMID 18211015

-

--PMID 16386088

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.254051+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "topicalpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CC"
}