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PEPDIA-INT-005004

Gold

Cycloviolacin Y4

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

GVPCGESCVFIPCITGVIGCSCSSNVCYLN

Indexed sequence30 aa

1GVPCGESCVFIPCITGVIGCSCSSNVCYLN

Length

Molecular weight

Formula

Structure type

Cyclic

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic10

Membrane affinity proxy

Polar13

Solubility proxy

Charged1

Net charge proxy -1

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

partial sequence only structural context

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

3025.542 Da

Molecular formula

Not calculated

Theoretical pI

4.05

Net charge at pH 7

-1.2975

GRAVY

1.0467

Instability index

36.8167

Aromaticity

0.0667

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

not generated modification context

Not calculated for this record

HELM 2.0

not generated modification context

Not calculated for this record

Canonical SMILES

not generated modification context

Not calculated for this record

Isomeric SMILES

not generated modification context

Not calculated for this record

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-005004,
  title = {Cycloviolacin Y4},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-005004},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Cycloviolacin Y4. (2026). PepDiana record PEPDIA-INT-005004. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-005004

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (20 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P005004_ACT_apd_0000	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	AP01080apd / linked
CTPDB_P005004_ACT_apd_0001	Antiviral	Anti-HIV	Not available in the current structured import	Unknown	Not reported by source	AP01080apd / linked
CTPDB_P005004_ACT_apd_0002	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	AP01080apd / linked
CTPDB_P005004_ACT_camp_0003	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ769camp / linked
CTPDB_P005004_ACT_dbaasp_0004	Antimicrobial	-	2.01 µM	Haemonchus contortus	Not reported by source	DBAASPS_12168_chain0dbaasp / linked
CTPDB_P005004_ACT_dbaasp_0005	Antimicrobial	-	2.27 µM	Trichostrongylus colubriformis	Not reported by source	DBAASPS_12168_chain0dbaasp / linked
CTPDB_P005004_ACT_dbaasp_0006	Antimicrobial	-	0.12 µM	HIV	Not reported by source	DBAASPS_12168_chain0dbaasp / linked
CTPDB_P005004_ACT_dramp_0007	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP00836dramp / linked
CTPDB_P005004_ACT_dramp_0008	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP00836dramp / linked
CTPDB_P005004_ACT_hemolytik_0009	Toxicity	Hemolytic	9.3 µM	Erythrocytes	Not reported by source	1028hemolytik / linked
CTPDB_P005004_ACT_plantpepdb_0010	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	PPepDB_274plantpepdb / linked
CTPDB_P005004_ACT_plantpepdb_0011	Antiviral	Anti-HIV	Not available in the current structured import	Unknown	Not reported by source	PPepDB_274plantpepdb / linked
CTPDB_P005004_ACT_plantpepdb_0012	Antiparasitic	Nematocide	Not available in the current structured import	Unknown	Not reported by source	PPepDB_274plantpepdb / linked
CTPDB_P005004_ACT_plantpepdb_0013	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	PPepDB_274plantpepdb / linked
CTPDB_P005004_ACT_plantpepdb_0014	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	PPepDB_274plantpepdb / linked
CTPDB_P005004_ACT_satpdb_0015	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb12922satpdb / linked
CTPDB_P005004_ACT_satpdb_0016	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb12922satpdb / linked
CTPDB_P005004_ACT_satpdb_0017	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb12922satpdb / linked
CTPDB_P005004_ACT_satpdb_0018	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb15555satpdb / linked
CTPDB_P005004_ACT_satpdb_0019	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb15555satpdb / linked

Provenance

Source database records (8)

apd

AP01080

Raw sequence

GVPCGESCVFIPCITGVIGCSCSSNVCYLN

camp

CAMPSQ769

Raw sequence

GVPCGESCVFIPCITGVIGCSCSSNVCYLN

dbaasp

DBAASPS_12168_chain0

Raw sequence

GVPCGESCVFIPCITGVIGCSCSSNVCYLN

dramp

DRAMP00836

Raw sequence

GVPCGESCVFIPCITGVIGCSCSSNVCYLN

hemolytik

1028

Raw sequence

GVPCGESCVFIPCITGVIGCSCSSNVCYLN

plantpepdb

PPepDB_274

Raw sequence

GVPCGESCVFIPCITGVIGCSCSSNVCYLN

satpdb

satpdb12922

Raw sequence

GVPCGESCVFIPCITGVIGCSCSSNVCYLN

satpdb

satpdb15555

Raw sequence

GVPCGESCVFIPCITGVIGCSCSSNVCYLN

Citation trail

Literature (3 records)

Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.

Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ2008

J Nat Prod2008PMID 18081258

The anthelmintic activity of the cyclotides: natural variants with enhanced activity

Colgrave ML, Kotze AC, Ireland DC, Wang CK, Craik DJ

Chembiochem2008PMID 18618891

Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.##Cyclotides as natural anti-HIV agents##The anthelmintic activity of the cyclotides: natural variants with enhanced activity

Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ.##David C Ireland, Conan K L Wang, Jennifer A Wilson, Kirk R Gustafson, David J Craik##Michelle L Colgrave, Andrew C Kotze, David C Ireland, Conan K Wang, David J Craik

J Nat Prod2008PMID 18008336

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.491115+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "9.3",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "1.7",
      "source_db": "dbaasp",
      "assay_method": "IC50",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "CEM-SS cells"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref:18081258] HD50=9.3 μM against human type A red blood cells.",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.18008336]CEM-SS cells:IC50=1720 nM.",
      "toxicity_type": "Cytotoxic"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCSCCSBSGGGSSSSBGGGSSCCSTTCC"
}