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PEPDIA-INT-004630

Silver

Cathelicidin Hydrostatin-AMP2

60

Quality

1

Source DBs

10

Activities

1

Source refs

1

Literature

0

Patents

Integrated record

Sequence and molecular profile

KRFKKFFKKLRKSVKKRVKKFFKKPKVIGVSIPF
Indexed sequence34 aa
1KRFKKFFKKLRKSVKKRVKKFFKKPKVIGVSIPF

Length

34

Molecular weight

4197.37 Da

Formula

C206H344N56O37

Structure type

-

Synthesis

Ribosomal

Chirality

-

Family

-

Gene

-

Residue composition

K
13
F
6
V
4
R
3
S
2
P
2
I
2
L
1
G
1

Physicochemical profile

Hydrophobic13

Membrane affinity proxy

Polar2

Solubility proxy

Charged16

Net charge proxy +16

Aromatic6

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

4197.2882 Da

Molecular formula

C206H344N56O37

Theoretical pI

12

Net charge at pH 7

15.7471

GRAVY

-0.6765

Instability index

17.1971

Aromaticity

0.1765

Topological polar surface area

1570.46 Ų

cLogP

-6.2896

Hydrogen-bond donors

57

Hydrogen-bond acceptors

53

Rotatable bonds

153

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

KRFKKFFKKLRKSVKKRVKKFFKKPKVIGVSIPF

HELM 2.0

validated simple linear

PEPTIDE1{K.R.F.K.K.F.F.K.K.L.R.K.S.V.K.K.R.V.K.K.F.F.K.K.P.K.V.I.G.V.S.I.P.F}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(Cc1ccccc1)NC(=O)C(CCCNC(=N)N)NC(=O)C(N)CCCCN)C(C)C)C(C)C)C(C)C)C(=O)NCC(=O)NC(C(=O)NC(CO)C(=O)NC(C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O)C(C)CC)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-004630,
  title = {Cathelicidin Hydrostatin-AMP2},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-004630},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Cathelicidin Hydrostatin-AMP2. (2026). PepDiana record PEPDIA-INT-004630. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-004630

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (10 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P004630_ACT_dbaasp_0000Antimicrobial-16 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_20725_chain0dbaasp / linked
CTPDB_P004630_ACT_dbaasp_0001Antimicrobial-32 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_20725_chain0dbaasp / linked
CTPDB_P004630_ACT_dbaasp_0002Antimicrobial-64 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_20725_chain0dbaasp / linked
CTPDB_P004630_ACT_dbaasp_0003Antimicrobial-128 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_20725_chain0dbaasp / linked
CTPDB_P004630_ACT_dbaasp_0004Antimicrobial-64 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_20725_chain0dbaasp / linked
CTPDB_P004630_ACT_dbaasp_0005Antimicrobial-32 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_20725_chain0dbaasp / linked
CTPDB_P004630_ACT_dbaasp_0006Antimicrobial-32 µg/mlKlebsiella pneumoniaeNot reported by sourceDBAASPS_20725_chain0dbaasp / linked
CTPDB_P004630_ACT_dbaasp_0007Antimicrobial-32 µg/mlCutibacterium acnes ATCC 6919Not reported by sourceDBAASPS_20725_chain0dbaasp / linked
CTPDB_P004630_ACT_dbaasp_0008Antimicrobial-32 µg/mlStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_20725_chain0dbaasp / linked
CTPDB_P004630_ACT_dbaasp_0009Antimicrobial-32 µg/mlMurine macrophage cells RAW 264.7Not reported by sourceDBAASPS_20725_chain0dbaasp / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

35

Records

1

Papers

35

Positive

0

Negative

1

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003777View all experimental records

Provenance

Source database records (1)

dbaasp

DBAASPS_20725_chain0

Raw sequence

KRFKKFFKKLRKSVKKRVKKFFKKPKVIGVSIPF

Citation trail

Literature (1 records)

[{"citation": "", "authors": [{"name": "Wang S", "description": ""}, {"name": "Fan L", "description": "Fan L"}, {"name": "Pan H", "description": "Pan H"}, {"name": "Li Y", "description": ""}, {"name": "Zhao X", "description": ""}, {"name": "Qiu Y", "description": ""}, {"name": "Lu Y", "description": ""}], "journal": {"name": "Molecules", "description": "MOLECULES"}, "year": 2023, "volume": "28", "pages": "2082", "title": "Identification and Characterization of a Novel Cathelicidin from Hydrophis

[{"citation": "", "authors": [{"name": "Wang S", "description": ""}, {"name": "Fan L", "description": "Fan L"}, {"name": "Pan H", "description": "Pan H"}, {"name": "Li Y", "description": ""}, {"name": "Zhao X", "description": ""}, {"name": "Qiu Y", "description": ""}, {"name": "Lu Y", "description": ""}], "journal": {"name": "Molecules", "description": "MOLECULES"}, "year": 2023, "volume": "28", "pages": "2082", "title": "Identification and Characterization of a Novel Cathelicidin from Hydrophis

--

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:18.424514+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "32",
      "source_db": "dbaasp",
      "assay_method": "8.08% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Mouse fibroblasts L929"
    },
    {
      "unit": "µg/ml",
      "value": "32",
      "source_db": "dbaasp",
      "assay_method": "5.89% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human keratinocytes HaCat"
    },
    {
      "unit": "µg/ml",
      "value": "250",
      "source_db": "dbaasp",
      "assay_method": "4.6% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}
Source metadata
[
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  }
]