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PEPDIA-INT-004265

Gold

Defensin-derived L-Peptide C

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

ALYLAIRRR

Indexed sequence9 aa

1ALYLAIRRR

Length

Molecular weight

1131.40 Da

Formula

C51H90N18O11

Structure type

Linear

Synthesis

Synthetic

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic6

Membrane affinity proxy

Polar0

Solubility proxy

Charged3

Net charge proxy +3

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1131.3742 Da

Molecular formula

C51H90N18O11

Theoretical pI

11.7114

Net charge at pH 7

2.7948

GRAVY

0.1

Instability index

136.1778

Aromaticity

0.1111

Topological polar surface area

502.05 Å²

cLogP

-2.8071

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

ALYLAIRRR

HELM 2.0

validated simple linear

PEPTIDE1{A.L.Y.L.A.I.R.R.R}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(C)C)NC(=O)C(C)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-004265,
  title = {Defensin-derived L-Peptide C},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-004265},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Defensin-derived L-Peptide C. (2026). PepDiana record PEPDIA-INT-004265. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-004265

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (29 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P004265_ACT_camp_0000	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9739camp / linked
CTPDB_P004265_ACT_camp_0001	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9739camp / linked
CTPDB_P004265_ACT_dbaasp_0002	Antimicrobial	-	600 µg/ml	Staphylococcus aureus KO-4	Not reported by source	DBAASPS_2588_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0003	Antimicrobial	-	400 µg/ml	Pseudomonas aeruginosa	Not reported by source	DBAASPS_2588_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0004	Antimicrobial	-	125 µM	Trypanosoma brucei brucei GUT Tat3.1	Not reported by source	DBAASPS_2588_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0005	Antimicrobial	-	1.5 µg/ml	Staphylococcus aureus ATCC 6538P	Not reported by source	DBAASPS_2588_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0006	Antimicrobial	-	24 µg/ml	Staphylococcus aureus	Not reported by source	DBAASPS_2588_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0007	Antimicrobial	-	3 µg/ml	Escherichia coli JM109	Not reported by source	DBAASPS_2588_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0008	Antimicrobial	-	60 µg/ml	Trichophyton mentagrophytes IFO 5466	Not reported by source	DBAASPS_2588_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0009	Antimicrobial	-	30 µg/ml	Staphylococcus aureus KO-4	Not reported by source	DBAASPS_2589_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0010	Antimicrobial	-	30 µg/ml	Pseudomonas aeruginosa	Not reported by source	DBAASPS_2589_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0011	Antimicrobial	-	95±12 µM	Trypanosoma brucei brucei GUT Tat3.1	Not reported by source	DBAASPS_2589_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0012	Antimicrobial	-	140±21 µM	Mouse myeloma P3-X63-Ag8.653	Not reported by source	DBAASPS_2589_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0013	Antimicrobial	-	447±41 µM	Human cervical carcinoma HeLa	Not reported by source	DBAASPS_2589_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0014	Antimicrobial	-	>640 µM	African green monkey kidney cancer Cos-1	Not reported by source	DBAASPS_2589_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0015	Antimicrobial	-	>640 µM	Human squamous lung carcinoma RERF-LC-AI	Not reported by source	DBAASPS_2589_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0016	Antimicrobial	-	>640 µM	Human glioblastoma U251-MG	Not reported by source	DBAASPS_2589_chain0dbaasp / linked
CTPDB_P004265_ACT_dbaasp_0017	Antimicrobial	-	>640 µM	Human lung cancer VA-13	Not reported by source	DBAASPS_2589_chain0dbaasp / linked
CTPDB_P004265_ACT_dramp_0018	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP04322dramp / linked
CTPDB_P004265_ACT_dramp_0019	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP04322dramp / linked
CTPDB_P004265_ACT_dramp_0020	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP34310dramp / linked
CTPDB_P004265_ACT_dramp_0021	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP34310dramp / linked
CTPDB_P004265_ACT_parapep_0022	Antiparasitic	Antiparasitic	Not available in the current structured import	Unknown	Cell numbers counted by Z1 Coulter Counter	1314parapep / linked
CTPDB_P004265_ACT_parapep_0023	Antiparasitic	Antiparasitic	125.0 µM	Unknown	Cell numbers counted by Z1 Coulter Counter	1319parapep / linked
CTPDB_P004265_ACT_satpdb_0024	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb15568satpdb / linked
CTPDB_P004265_ACT_satpdb_0025	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb16531satpdb / linked
CTPDB_P004265_ACT_satpdb_0026	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb16531satpdb / linked
CTPDB_P004265_ACT_satpdb_0027	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb22004satpdb / linked
CTPDB_P004265_ACT_satpdb_0028	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb22004satpdb / linked

Provenance

Source database records (10)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

camp

CAMPSQ9739

Raw sequence

ALYLAIRRR

dbaasp

DBAASPS_2588_chain0

Raw sequence

ALYLAIRRR

dbaasp

DBAASPS_2589_chain0

Raw sequence

alylairrr

dramp

DRAMP04322

Raw sequence

ALYLAIRRR

dramp

DRAMP34310

Raw sequence

alylairrr

parapep

1314

Raw sequence

alylairrr

parapep

1319

Raw sequence

ALYLAIRRR

satpdb

satpdb15568

Raw sequence

ALYLAIRRR

satpdb

satpdb16531

Raw sequence

ALYLAIRRR

satpdb

satpdb22004

Raw sequence

alylairrr

Citation trail

Literature (4 records)

-

--PMID 9931294

In vitro Activity of Diastereomeric Antimicrobial Peptides Alone and in Combination with Antibiotics against Methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa

Iwasaki T, Saido-Sakanaka H, Asaoka A, Taylor D, Ishibashi J, Yamakawa M

J Insect Biotechnol Sericol2007PMID 19584534

In vitro Activity of Diastereomeric Antimicrobial Peptides Alone and in Combination with Antibiotics against Methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa

Iwasaki T, Saido-Sakanaka H, Asaoka A, Taylor D, Ishibashi J, Yamakawa M

J Insect Biotechnol Sericol2007PMID 15003352

In vitro Activity of Diastereomeric Antimicrobial Peptides Alone and in Combination with Antibiotics against Methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa

Iwasaki T, Saido-Sakanaka H, Asaoka A, Taylor D, Ishibashi J, Yamakawa M

J Insect Biotechnol Sericol2007PMID 19154767

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:14.330103+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Rabbit erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Murine macrophage cells JA-4"
    },
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Mouse fibroblasts L929"
    },
    {
      "unit": "µM",
      "value": "640",
      "source_db": "dbaasp",
      "assay_method": "3% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCGGGCTTC"
}